Article
Biochemistry & Molecular Biology
Danilo Predes, Lorena A. Maia, Isadora Matias, Hannah Paola Mota Araujo, Carolina Soares, Fernanda G. Q. Barros-Aragao, Luiz F. S. Oliveira, Renata R. Reis, Nathalia G. Amado, Alessandro B. C. Simas, Fabio A. Mendes, Flavia C. A. Gomes, Claudia P. Figueiredo, Jose G. Abreu
Summary: This study identifies quercitrin as a novel Wnt signaling potentiator through various experimental models and approaches. Quercitrin enhances the signaling pathway and has positive effects on neuronal function. Moreover, it rescues memory impairment caused by Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Yuhui Mi, Lei Zhong, Saijian Lu, Po Hu, Yang Pan, Xuelin Ma, Binghui Yan, Zhenhuan Wei, Guangming Yang
Summary: The study aimed to evaluate the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and to reveal the mechanisms involved, including the Wnt/beta-catenin pathway and TERT.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Veterinary Sciences
Bo Wang, Shanshan Wang, Manyi Ding, Han Lu, Hao Wu, Yao Li
Summary: This study found that moderate dietary supplementation of quercetin has a positive effect on calcium and phosphorus metabolism in broilers, and this effect is mediated through the regulation of the Wnt signaling pathway.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Carla Macheroni, Thais Fabiana Gameiro Lucas, Deborah Simao Souza, Carolina Meloni Vicente, Gustavo Jose da Silva Pereira, Itabajara da Silva Vaz Junior, Maria Aparecida Juliano, Catarina Segreti Porto
Summary: This study investigated the expression of estrogen receptors in human testicular embryonal carcinoma NT2/D1 cells and their effects on cell proliferation. The results showed that estrogen receptors were mainly located in the nuclei, while a splice variant was found in the perinuclear region and cytoplasm. Activation of estrogen receptors increased the expression of cell cycle proteins and promoted cell proliferation. Additionally, estrogen induced an increase in cell number and viability, and this effect was blocked by estrogen receptor antagonists.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Cell & Tissue Engineering
Xiaohong Zhao, Ruyu Bian, Fan Wang, Ying Wang, Xue Li, Yicheng Guo, Xiaorong Zhang, Gaoxing Luo, Rixing Zhan
Summary: The study demonstrated that GDF-5 promotes mouse EpSCs proliferation through the Foxg1-cyclin D1 signaling pathway, suggesting a potential new approach for wound healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Ji-Hye Hwang, Hyun-Young Lee, Kyung Bae Chung, Hae June Lee, Jino Kim, Kiwon Song, Do-Young Kim
Summary: NTAPP may stimulate hair growth by activating the Wnt/β-catenin signaling pathway, potentially serving as a non-pharmacological therapeutic intervention for alopecia.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Chuanrui Xu, Zhong Xu, Yi Zhang, Matthias Evert, Diego F. Calvisi, Xin Chen
Summary: Deregulated Wnt/β-catenin signaling is a major genetic alteration in hepatocellular carcinoma (HCC), and its activation plays an oncogenic role in hepatocarcinogenesis. The activated pathway is associated with specific gene expression patterns and pathological features, and it synergizes with other signaling cascades to promote HCC formation. Therefore, understanding and targeting this pathway has important implications for the diagnosis, classification, and personalized treatment of HCC.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Cell Biology
Mir Hilal Ahmad, Balaram Ghosh, Moshahid Alam Rizvi, Mansoor Ali, Loveleena Kaur, Amal Chandra Mondal
Summary: Neuroblastoma is a common heterogeneous extracranial cancer in infancy that is associated with aberrant activation of the Wnt signaling pathway. The Wnt signaling pathway regulates the development and differentiation of neural crest cells and affects the proliferation and metastasis of neuroblastoma. Inhibiting the Wnt signaling pathway can induce apoptosis and prevent the occurrence of neuroblastoma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Hyo In Kim, Sol Ji Lee, Yu-Jeong Choi, Min Jeong Kim, Tai Young Kim, Seong-Gyu Ko
Summary: This study found that quercetin can induce apoptosis in GBM cells by inhibiting the Axl/IL-6/STAT3 signaling pathway, suggesting its potential as an anticancer agent.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Ian James Bell, Matthew Sheldon Horn, Terence John Van Raay
Summary: The non-canonical Wnt signaling pathways have different roles in cancer and development, involving calcium and Vangl2. Cells tend to choose non-canonical Wnt signaling over canonical Wnt signaling when presented with a choice, but this occurs rarely in vivo.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Mahmure Ayse Tayman, Oemer Gunhan, Alpdogan Kantarci, Muhittin Abdulkadir Serdar, Meral Gunhan
Summary: This study aimed to evaluate the activity of the Wnt/beta-catenin signaling pathway in gingival samples obtained from patients with periodontitis. The results showed that periodontal inflammation disrupts the Wnt/beta-catenin signaling pathway, leading to tissue inflammation and changes in morphology. This finding may shed light on the pathogenesis of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Vanda Balint, Danijela Stanisavljevic Ninkovic, Natasa Anastasov, Stefan Lazic, Natasa Kovacevic-Grujicic, Milena Stevanovic, Andrijana Lazic
Summary: Astrocytes are key cells in the CNS that can be regulated by miRNAs to affect cellular functions, including senescence. Studies suggest that miR-21 may be a potential regulator of astrocyte senescence.
BIOCHEMISTRY-MOSCOW
(2021)
Article
Food Science & Technology
Mengqi Wei, Caihong Ye, Huakun Huang, Chunmei Yang, Lulu Zhang, Yanran Huang, Yuping Wang, Xiaoji Luo, Jinyong Luo
Summary: The study found that acacetin can inhibit the proliferation, migration, and invasion of osteosarcoma (OS) cells, and promote apoptosis. Acacetin has little impact on normal cells. By regulating Wnt/beta-catenin and JNK signaling pathways, acacetin may inhibit tumor growth of human OS cells.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
J. P. Jose Merlin, Graham Dellaire, Kieran Murphy, H. P. Vasantha Rupasinghe
Summary: Lung cancer has the highest mortality rate globally and is often diagnosed at late stages, necessitating genotoxic chemotherapy. Cancer prevention, including the use of antioxidants, is a major focus. The study found that an antioxidant formulation has the potential to reduce DNA damage, showing promise as a chemoprotectant by attenuating activation of kinase following carcinogen exposure.
Article
Biochemistry & Molecular Biology
Vanda Balint, Danijela Stanisavljevic Ninkovic, Natasa Anastasov, Stefan Lazic, Natasa Kovacevic-Grujicic, Milena Stevanovic, Andrijana Lazic
Summary: Astrocytes are key cells in the CNS that can be regulated by miRNAs to affect cellular functions, including senescence. Studies suggest that miR-21 may be a potential regulator of astrocyte senescence.
BIOCHEMISTRY-MOSCOW
(2021)
Article
Agricultural Engineering
Marija Ivanov, Jelena Bozunovic, Uros Gasic, Danijela Drakulic, Milena Stevanovic, Nemanja Rajcevic, Dejan Stojkovic
Summary: The study explored the impact of different solvents on the bioactivities of Salvia nemorosa L. inflorescences, highlighting butanol as the most suitable solvent for wound healing improvement and ethanol/water combination for the highest antioxidant potential. The extracts showed potential in antimicrobial and antibiofilm activities, with one extract demonstrating immunomodulatory action and antibacterial mechanism. Overall, S. nemorosa inflorescences were found to be rich sources of bioactive polyphenols with various therapeutic applications.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Biochemistry & Molecular Biology
Andrijana Lazic, Vanda Balint, Danijela Stanisavljevic Ninkovic, Mina Peric, Milena Stevanovic
Summary: This review summarizes the latest research on astrocyte reactivation and senescence, and compares their similarities and differences in terms of morphology, function, and molecular aspects. The article specifically focuses on the role of these cellular changes in neurodegenerative diseases, and discusses the potential of astrocytes as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Krstic, Aleksandar Pavic, Edina Avdovic, Zoran Markovic, Milena Stevanovic, Isidora Petrovic
Summary: This paper investigates the anticancer potential of coumarin-palladium(II) complex against pancreatic carcinoma cells. The results demonstrate significant inhibition of the growth of pancreatic carcinoma cells both in vitro and in vivo, as well as promising therapeutic effects on zebrafish-pancreatic adenocarcinoma xenografts.
Review
Cell Biology
Danijela Drakulic, Marija Schwirtlich, Isidora Petrovic, Marija Mojsin, Milena Milivojevic, Natasa Kovacevic-Grujicic, Milena Stevanovic
Summary: Glioblastoma (GBM) is a common and highly lethal brain tumor, and current treatment methods have limited success. Therefore, further research is needed to understand the molecular characteristics and develop targeted therapies to improve clinical outcomes for patients with GBM.
Article
Optics
Sladjana Dorontic, Aurelio Bonasera, Michelangelo Scopelliti, Marija Mojsin, Milena Stevanovic, Olivera Markovic, Svetlana Jovanovic
Summary: Non-toxic, cheap, easy, rapid, and sensitive methods are needed for the detection of large amounts of hazardous and toxic substances in the environment. Blue luminescent graphene quantum dots (GQDs) were produced by electrochemical cleavage of graphite electrodes followed by gamma irradiation in the presence of ethylenediamine (EDA), and they were able to detect metal ions. Additionally, gamma irradiated GQDs acted as an ultra-sensitive turn-on probe for Malathion detection.
JOURNAL OF LUMINESCENCE
(2022)
Article
Nanoscience & Nanotechnology
Zoran M. Markovic, Milica D. Budimir, Martin Danko, Dusan D. Milivojevic, Pavel Kubat, Danica Z. Zmejkoski, Vladimir B. Pavlovic, Marija M. Mojsin, Milena J. Stevanovic, Biljana M. Todorovic Markovic
Summary: In this study, carbon quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route, and then encapsulated into polyurethane films by a swelling-encapsulation-shrink method. The precursor was found to have a significant influence on the structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed low antibacterial potential and dark cytotoxicity, while cellular uptake experiments confirmed the potential use of these dots as bioimaging probes.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zoran M. Markovic, Maria Kovacova, Sanja R. Jeremic, Stefan Nagy, Dusan D. Milivojevic, Pavel Kubat, Angela Kleinova, Milica D. Budimir, Marija M. Mojsin, Milena J. Stevanovic, Adriana Annusova, Zdeno Spitalsky, Biljana M. Todorovic Markovic
Summary: The development of new types of antimicrobial coatings is of great significance in tackling the increasing problem of pathogen transmission from infectious surfaces. This study presents highly potent antimicrobial polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer dots. These composites can effectively eradicate Escherichia coli and Staphylococcus aureus within a short period of time under low-power blue light, and show low toxicity to cells. They can be used for sterilization of frequently touched objects in the healthcare industry.
Review
Biochemistry & Molecular Biology
Milena Stevanovic, Natasa Kovacevic-Grujicic, Isidora Petrovic, Danijela Drakulic, Milena Milivojevic, Marija Mojsin
Summary: Glioblastoma (GBM) is the most devastating primary brain malignancy, and the prognosis for most GBM patients remains poor. The interplay between SOX genes and lncRNAs plays important roles in tumor initiation, progression, therapy resistance, and recurrence in GBM. This review systematically summarizes the current literature data on the complex interplay between SOX genes and lncRNAs in GBM and highlights its significance in searching for new biomarkers and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Zoran M. Markovic, Aleksandra S. Misovic, Danica Z. Zmejkoski, Nemanja M. Zdravkovic, Janez Kovac, Danica V. Bajuk-Bogdanovic, Dusan D. Milivojevic, Marija M. Mojsin, Milena J. Stevanovic, Vladimir B. Pavlovic, Biljana M. Todorovic Markovic
Summary: Developing new medicines for infectious diseases is currently a major challenge. Carbon quantum dots, a new member of the carbon nanomaterials family, show potential as visible-light-triggered antibacterial agents. This study investigates the antibacterial and cytotoxic activities of gamma-ray-irradiated carbon quantum dots, finding that they have antibacterial activity and are non-toxic to human cells.
Article
Biochemistry & Molecular Biology
Anna Kloska, Agata Gielczyk, Tomasz Grzybowski, Rafal Ploski, Sylwester M. Kloska, Tomasz Marciniak, Krzysztof Palczynski, Urszula Rogalla-Ladniak, Boris A. Malyarchuk, Miroslava V. Derenko, Natasa Kovacevic-Grujicic, Milena Stevanovic, Danijela Drakulic, Slobodan Davidovic, Magdalena Spolnicka, Magdalena Zubanska, Marcin Wozniak
Summary: Data obtained through massive parallel sequencing can be useful in population genetics studies. Machine learning techniques were used in this study to classify DNA samples from Slavic and non-Slavic individuals, with the aim of discerning the genetic provenance of individuals of Slavic descent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Milena Stevanovic, Andrijana Lazic, Marija Schwirtlich, Danijela Stanisavljevic Ninkovic
Summary: The pursuit of eternal youth and immortality dates back to ancient times. Ageing is a natural process accompanied by functional declines, which contribute to age-related diseases. Stem cell exhaustion is a hallmark of ageing, and the SOX transcription factors have significant roles in stem cell self-renewal and differentiation. Understanding the molecular mechanisms of ageing and the involvement of SOX transcription factors can help develop strategies for delaying ageing and preventing age-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Milena Stevanovic, Danijela Stanisavljevic Ninkovic, Marija Mojsin, Danijela Drakulic, Marija Schwirtlich
Summary: Precise tuning of gene expression, accomplished by regulatory networks of transcription factors, epigenetic modifiers, and microRNAs, is crucial for proper neural development and brain function. The complex regulatory network between SOX transcription factors and microRNAs plays important roles in neurogenesis. Deregulated SOX/microRNA interplay has been associated with various brain pathologies. Therapeutic strategies targeting the interplay have emerged as a promising tool for neural tissue regeneration and neurorestoration.
NEURAL REGENERATION RESEARCH
(2022)
Article
Chemistry, Applied
Mia Radonjic, Jelena Petrovic, Milena Milivojevic, Milena Stevanovic, Jasmina Stojkovska, Bojana Obradovic
Summary: A multidisciplinary approach was utilized in this study to develop a biomimetic system for 3D cultures of cancer cells. Cancer cell lines were immobilized in alginate microbeads and microfibers and cultured under different conditions. Chemical engineering methods were used to explain the results obtained. The study showed that fluid shear stresses affected the viability of cancer cells, and different velocities had different effects on the proliferation of glioma cells. Moreover, the mass transport within the microfibers was described using a diffusion-advection-reaction model.
CHEMICAL INDUSTRY & CHEMICAL ENGINEERING QUARTERLY
(2022)
Article
Biology
Dejan Stojkovic, Danijela Drakulic, Maria Ines Dias, Gokhan Zengin, Lillian Barros, Marija Ivanov, Uros Gasic, Nemanja Rajcevic, Milena Stevanovic, Isabel C. F. R. Ferreira, Marina Sokovic
Summary: This study explores the anti-neurodegenerative and anti-glioblastoma potential of Phlomis fruticosa extract. The extract was found to reduce the activities of enzymes linked to neurodegenerative diseases and exhibit excellent antioxidant potential. It also showed cytotoxic effects on glioblastoma cells and increased the production of ROS. Twelve different polyphenols were identified in the extract, with cis 3-O-caffeoylquinic acid being the most abundant.
