Recognition of self and altered self by T cells in autoimmunity and allergy

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?

(2013) P. Marrack et al.   Cold Spring Harbor Perspectives in Medicine

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies

(2012) Alessandra Fierabracci et al.   AUTOIMMUNITY REVIEWS

Processing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system

(2012) Jamie M. Ireland et al.   Autophagy

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

(2012) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

(2012) Franca Rosa Guerini et al.   PLoS One

T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy

(2012) L. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4

(2012) Y. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenetic Mechanisms Leading to Thyroid Autoimmunity: Recent Advances in Identifying Susceptibility Genes and Regions

(2011) Oliver J. Brand et al.   CURRENT GENOMICS

CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes

(2011) Kathryn Haskins et al.   CURRENT OPINION IN IMMUNOLOGY

Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection

(2011) Yiyuan Yin et al.   EMBO JOURNAL

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

(2011) Lei Yin et al.   IMMUNITY

The immunological synapse: a cause or consequence of T-cell receptor triggering?

(2011) Balbino Alarcón et al.   IMMUNOLOGY

Twin studies in autoimmune disease: Genetics, gender and environment

(2011) Dimitrios P. Bogdanos et al.   JOURNAL OF AUTOIMMUNITY

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

(2011) Dhruv K. Sethi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of 19 Autoimmune Disease-associated Loci with Rheumatoid Arthritis in a Colombian Population: Evidence for Replication and Gene-Gene Interaction

(2011) H. A. DESHMUKH et al.   JOURNAL OF RHEUMATOLOGY

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

(2011) E. B. Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics for understanding and predicting clinical progression in multiple sclerosis

(2011) R. Depaz et al.   REVUE NEUROLOGIQUE

Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis

(2011) Yannick Allanore et al.   PLoS Genetics

Immunodeficiency secondary to anticytokine autoantibodies

(2010) Sarah K Browne et al.   Current Opinion in Allergy and Clinical Immunology

Staying Alive: T Cell Costimulation, CD28, and Bcl-xL

(2010) T. H. Watts   JOURNAL OF IMMUNOLOGY

The autoimmune TCR-Ob.2F3 can bind to MBP85–99/HLA-DR2 having an unconventional mode as in TCR-Ob.1A12

(2010) Zenichiro Kato et al.   MOLECULAR IMMUNOLOGY

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

(2010) James F Mohan et al.   NATURE IMMUNOLOGY

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

(2010) S. R. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti–CTLA-4 Antibody Therapy: Immune Monitoring During Clinical Development of a Novel Immunotherapy

(2010) Margaret K. Callahan et al.   SEMINARS IN ONCOLOGY

Mechanisms of costimulation

(2009) Arlene H. Sharpe   IMMUNOLOGICAL REVIEWS

Ins2 Deficiency Augments Spontaneous HLA-A*0201-Restricted T Cell Responses to Insulin

(2009) I. Jarchum et al.   JOURNAL OF IMMUNOLOGY

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

(2008) Philippa Marrack et al.   Annual Review of Immunology

Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species

(2008) Dan B. Rainbow et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

(2008) Shaodong Dai et al.   IMMUNITY

Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens

(2008) Kristine A. Kuhn et al.   MOLECULAR IMMUNOLOGY

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

(2007) Anish Suri et al.   CURRENT OPINION IN IMMUNOLOGY