Could Heat Therapy Be an Effective Treatment for Alzheimer’s and Parkinson’s Diseases? A Narrative Review

Regulation of Body Temperature by Autonomic and Behavioral Thermoeffectors

(2019) Zachary J. Schlader et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Gut-brain axis and the spread of α-synuclein pathology: vagal highway or dead end?

(2019) David P. Breen et al.   MOVEMENT DISORDERS

Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis

(2019) Matthew J. Maley et al.   PLoS One

The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases

(2019) Yan Liu et al.   LABORATORY INVESTIGATION

Heat therapy improves glucose tolerance and adipose tissue insulin signaling in obese women with polycystic ovary syndrome

(2019) Brett R Ely et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Heat therapy vs. supervised exercise therapy for peripheral arterial disease: a 12-week randomized, controlled trial

(2019) Ashley P. Akerman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Passive Heat Therapy in Sedentary Humans Increases Skeletal Muscle Capillarisation and eNOS Content but Not Mitochondrial Density or GLUT4 Content

(2019) Katie Hesketh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The relationship between perceived functional difficulties and the ability to live well with mild‐to‐moderate dementia: Findings from the IDEAL programme

(2019) Anthony Martyr et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization

(2019) Paul Samuel Hafen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of heat and cold on health, with special reference to Finnish sauna bathing

(2018) Ilkka Heinonen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Determining the potential sites of neural adaptation to cross-education: implications for the cross-education of muscle strength

(2018) Ashlyn K. Frazer et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle

(2018) Paul Samuel Hafen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Turning Up the Heat: An Evaluation of the Evidence for Heating to Promote Exercise Recovery, Muscle Rehabilitation and Adaptation

(2018) Hamish McGorm et al.   SPORTS MEDICINE

Preventive and promotive effects of habitual hot spa-bathing on the elderly in Japan

(2018) Toyoki Maeda et al.   Scientific Reports

Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease

(2018) Margaret Schenkman et al.   JAMA Neurology

Passive heat therapy protects against endothelial cell hypoxia-reoxygenation via effects of elevations in temperature and circulating factors

(2018) Vienna E. Brunt et al.   JOURNAL OF PHYSIOLOGY-LONDON

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Whole body heat exposure modulates acute glucose metabolism

(2018) Amy L. Kimball et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Acute and chronic effects of hot water immersion on inflammation and metabolism in sedentary, overweight adults

(2018) S. P. Hoekstra et al.   JOURNAL OF APPLIED PHYSIOLOGY

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Effects of dual-task aquatic exercises on functional mobility, balance and gait of individuals with Parkinson's disease: A randomized clinical trial with a 3-month follow-up

(2018) Adriano Zanardi da Silva et al.   COMPLEMENTARY THERAPIES IN MEDICINE

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

(2017) Prashant Bharadwaj et al.   JOURNAL OF ALZHEIMERS DISEASE

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson’s disease

(2017) Zoe Joanna Syrimi et al.   JOURNAL OF NEURAL TRANSMISSION

Global and regional economic costs of dementia: a systematic review

(2017) Junfang Xu et al.   LANCET

DNAJ Proteins in neurodegeneration: essential and protective factors

(2017) Christina Zarouchlioti et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Exercise-Induced Neuroprotection of the Nigrostriatal Dopamine System in Parkinson's Disease

(2017) Lijuan Hou et al.   Frontiers in Aging Neuroscience

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

(2017) Christopher P. Webster et al.   Frontiers in Molecular Neuroscience

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

The Cross-Education Phenomenon: Brain and Beyond

(2017) Ashlee M. Hendy et al.   Frontiers in Physiology

Effects of a low-resistance, interval bicycling intervention in Parkinson’s Disease

(2017) Mehmet Uygur et al.   PHYSIOTHERAPY THEORY AND PRACTICE

OUP accepted manuscript

(2016)   AGE AND AGEING

Heat therapy promotes the expression of angiogenic regulators in human skeletal muscle

(2016) Alisha M. Kuhlenhoelter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Thermotherapy reduces blood pressure and circulating endothelin-1 concentration and enhances leg blood flow in patients with symptomatic peripheral artery disease

(2016) Dustin Neff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Prescribing exercise interventions for patients with chronic conditions

(2016) Tammy C. Hoffmann et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Hsp72 and Hsp90α mRNA transcription is characterised by large, sustained changes in core temperature during heat acclimation

(2016) Oliver R. Gibson et al.   CELL STRESS & CHAPERONES

Whole body heat stress increases motor cortical excitability and skill acquisition in humans

(2016) Andrew E. Littmann et al.   CLINICAL NEUROPHYSIOLOGY

Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development

(2016) Sarah N. Fontaine et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation

(2016) Vienna E. Brunt et al.   JOURNAL OF APPLIED PHYSIOLOGY

Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans

(2016) Vienna E. Brunt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heat shock proteins as potential targets for protective strategies in neurodegeneration

(2016) Harm H Kampinga et al.   LANCET NEUROLOGY

The Effects of Heat Adaptation on Physiology, Perception and Exercise Performance in the Heat: A Meta-Analysis

(2016) Christopher J. Tyler et al.   SPORTS MEDICINE

Mild versus moderate stages of Alzheimer's disease: three-year outcomes in a routine clinical setting of cholinesterase inhibitor therapy

(2016) Carina Wattmo et al.   Alzheimers Research & Therapy

Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder

(2016) Clemens W. Janssen et al.   JAMA Psychiatry

Effects of passive heat stress on human somatosensory processing

(2015) Hiroki Nakata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Heat acclimation attenuates physiological strain and the HSP72, but not HSP90α, mRNA response to acute normobaric hypoxia

(2015) Oliver R. Gibson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

(2015) Thierry Paillard et al.   Journal of Clinical Neurology

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Isothermic and fixed-intensity heat acclimation methods elicit equal increases in Hsp72 mRNA

(2015) O. R. Gibson et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Effects of far-infrared sauna bathing on recovery from strength and endurance training sessions in men

(2015) Antti Mero et al.   SpringerPlus

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

(2014) Anthony H V Schapira et al.   LANCET

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Heat shock proteins in neurodegenerative disorders and aging

(2014) Rehana K. Leak   Journal of Cell Communication and Signaling

Immediate effects of high-speed cycling intervals on bradykinesia in Parkinson's disease

(2014) Mehmet Uygur et al.   PHYSIOTHERAPY THEORY AND PRACTICE

Heat stress promotes skeletal muscle regeneration after crush injury in rats

(2013) Kousuke Takeuchi et al.   ACTA HISTOCHEMICA

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Physical activity and the brain: A review of this dynamic, bi-directional relationship

(2013) Paul D. Loprinzi et al.   BRAIN RESEARCH

Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure

(2013) Oliver R. Gibson et al.   CELL STRESS & CHAPERONES

Vascular Risk Factors and Neurodegeneration in Ageing Related Dementias: Alzheimer’s Disease and Vascular Dementia

(2013) Rufus Akinyemi et al.   Current Alzheimer Research

Intramuscular Heating Through Fluidotherapy and Heat Shock Protein Response

(2013) John P. Vardiman et al.   JOURNAL OF ATHLETIC TRAINING

The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol

(2013) Bernadett Kalmar et al.   PHARMACOLOGY & THERAPEUTICS

Effects of the Finnish Alzheimer Disease Exercise Trial (FINALEX)

(2013) Kaisu H. Pitkälä et al.   JAMA Internal Medicine

Heat stress activates the Akt/mTOR signalling pathway in rat skeletal muscle

(2012) T. Yoshihara et al.   Acta Physiologica

Treatment with a coinducer of the heat shock response delays muscle denervation in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

(2012) Bernadett Kalmar et al.   Amyotrophic Lateral Sclerosis

Plasma Hsp72 (HSPA1A) and Hsp27 (HSPB1) expression under heat stress: influence of exercise intensity

(2012) Julien D. Périard et al.   CELL STRESS & CHAPERONES

Acute heat stress prior to downhill running may enhance skeletal muscle remodeling

(2012) Chad D. Touchberry et al.   CELL STRESS & CHAPERONES

Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology

(2012) M. Asahina et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Six-Month Walking Program Changes Cognitive and ADL Performance in Patients With Alzheimer

(2011) Massimo Venturelli et al.   American Journal of Alzheimers Disease and Other Dementias

Effect of Repeated Sauna Treatment on Exercise Tolerance and Endothelial Function in Patients With Chronic Heart Failure

(2011) Takashi Ohori et al.   AMERICAN JOURNAL OF CARDIOLOGY

Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease

(2011) T. R. Melzer et al.   BRAIN

Eleven days of moderate exercise and heat exposure induces acclimation without significant HSP70 and apoptosis responses of lymphocytes in college-aged males

(2011) Lindsay L. Hom et al.   CELL STRESS & CHAPERONES

Loss of motor function in preclinical Alzheimer’s disease

(2011) Aron S Buchman et al.   Expert Review of Neurotherapeutics

Cerebrovascular and corticomotor function during progressive passive hyperthermia in humans

(2011) Emma Z. Ross et al.   JOURNAL OF APPLIED PHYSIOLOGY

Physical, occupational, speech and swallowing therapies and physical exercise in Parkinson’s disease

(2011) G. Ransmayr   JOURNAL OF NEURAL TRANSMISSION

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

How might physical activity benefit patients with Parkinson disease?

(2011) Arlène D. Speelman et al.   Nature Reviews Neurology

Does vigorous exercise have a neuroprotective effect in Parkinson disease?

(2011) J. E. Ahlskog   NEUROLOGY

Reduced Lean Mass in Early Alzheimer Disease and Its Association With Brain Atrophy

(2010) Jeffrey M. Burns et al.   ARCHIVES OF NEUROLOGY

Heat and exercise acclimation increases intracellular levels of Hsp72 and inhibits exercise-induced increase in intracellular and plasma Hsp72 in humans

(2010) Flávio de Castro Magalhães et al.   CELL STRESS & CHAPERONES

Responses of muscle mass, strength and gene transcripts to long-term heat stress in healthy human subjects

(2010) Katsumasa Goto et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Heat acclimation does not reduce the impact of hyperthermia on central fatigue

(2010) Marius Brazaitis et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

(2010) Karin M. Danzer et al.   FASEB JOURNAL

A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats

(2010) V. Ohno et al.   GENERAL PHYSIOLOGY AND BIOPHYSICS

Soleus Adaptation to Combined Exercise and Heat Acclimation

(2010) EINAT KODESH et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Parkinson's disease symptoms: The patient's perspective

(2010) Marios Politis et al.   MOVEMENT DISORDERS

Physical activities and future risk of Parkinson disease

(2010) Q. Xu et al.   NEUROLOGY

Predictors of future falls in Parkinson disease

(2010) G. K. Kerr et al.   NEUROLOGY

Heat shock proteins: Cellular and molecular mechanisms in the central nervous system

(2010) R. Anne Stetler et al.   PROGRESS IN NEUROBIOLOGY

Intima-Media Thickness and Regional Cerebral Blood Flow in Older Adults

(2010) Jitka Sojkova et al.   STROKE

Is There Muscular Weakness in Parkinsonʼs Disease?

(2009) Roberto Cano-de-la-Cuerda et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Hsp27 inhibits IKKβ-induced NF-κB activity and skeletal muscle atrophy

(2009) Stephen L. Dodd et al.   FASEB JOURNAL

Impact of Shear Rate Modulation on Vascular Function in Humans

(2009) Toni M. Tinken et al.   HYPERTENSION

Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications

(2009) Hiroaki Adachi et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers

(2009) Yasuharu Oishi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

(2009) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Proteomic profiling of phosphoproteins and glycoproteins responsive to wild-type alpha-synuclein accumulation and aggregation

(2008) Jayanarayan Kulathingal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Hsp70 overexpression inhibits NF-κB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy

(2008) Sarah M. Senf et al.   FASEB JOURNAL

Functional Role of HSP90 Complexes with Endothelial Nitric-oxide Synthase (eNOS) and Calpain on Nitric Oxide Generation in Endothelial Cells

(2008) Monica Averna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS

(2008) Bernadett Kalmar et al.   JOURNAL OF NEUROCHEMISTRY