Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis

Acarbose improves health and lifespan in aging HET3 mice

(2019) David E. Harrison et al.   AGING CELL

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

(2019) Byron J Smith et al.   BMC MICROBIOLOGY

Oscillospira and related bacteria - From metagenomic species to metabolic features

(2017) Uri Gophna et al.   ENVIRONMENTAL MICROBIOLOGY

Reappraisal and perspectives of clinical drug–drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus

(2017) Ranjeet Prasad Dash et al.   XENOBIOTICA

Effects of Acarbose on the Gut Microbiota of Prediabetic Patients: A Randomized, Double-blind, Controlled Crossover Trial

(2017) Xiuying Zhang et al.   Diabetes Therapy

Effects of Acarbose on the Gut Microbiota of Prediabetic Patients: A Randomized, Double-blind, Controlled Crossover Trial

(2017) Xiuying Zhang et al.   Diabetes Therapy

The microbiome in celiac disease: Beyond diet-genetic interactions

(2016) J. U. SCHER   CLEVELAND CLINIC JOURNAL OF MEDICINE

Short-Chain Fatty Acids Regulate Cytokines and Th17/Treg Cells in Human Peripheral Blood Mononuclear Cellsin vitro

(2016) M. Asarat et al.   IMMUNOLOGICAL INVESTIGATIONS

Oral administration of acarbose ameliorates imiquimod-induced psoriasis-like dermatitis in a mouse model

(2016) Hsin-Hua Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Increased Serum Interleukin-9 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Pathogenic Role or Just an Epiphenomenon?

(2015) Andréa Tavares Dantas et al.   DISEASE MARKERS

Therapeutic potential of α-glucosidase inhibitors in type 2 diabetes mellitus: an evidence-based review

(2015) Shashank R Joshi et al.   EXPERT OPINION ON PHARMACOTHERAPY

Germs and joints: the contribution of the human microbiome to rheumatoid arthritis

(2015) Geraint B Rogers   NATURE MEDICINE

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Microbiome reflects status of RA and response to therapy

(2015) Robert Phillips   Nature Reviews Rheumatology

Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis

(2015) F. Ciccia et al.   RHEUMATOLOGY

Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice

(2015) Hsin-Hua Chen et al.   Scientific Reports

Acarbose treatment affects the serum levels of inflammatory cytokines and the gut content of bifidobacteria in Chinese patients with type 2 diabetes mellitus

(2015) Benli Su et al.   Journal of Diabetes

Helios Enhances Treg Cell Function in Cooperation With FoxP3

(2015) Hiroaki Takatori et al.   Arthritis & Rheumatology

The gut microbiota of Colombians differs from that of Americans, Europeans and Asians

(2014) Juan S Escobar et al.   BMC MICROBIOLOGY

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Meta-analyses of human gut microbes associated with obesity and IBD

(2014) William A. Walters et al.   FEBS LETTERS

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

(2014) Chang H. Kim et al.   Immune Network

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Utilisation of Mucin Glycans by the Human Gut Symbiont Ruminococcus gnavus Is Strain-Dependent

(2013) Emmanuelle H. Crost et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA)

(2012) Jan M Hughes-Austin et al.   ANNALS OF THE RHEUMATIC DISEASES

Microbiota conservation and BMI signatures in adult monozygotic twins

(2012) Sebastian Tims et al.   ISME Journal

Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms

(2012) J Gregory Caporaso et al.   ISME Journal

Helios Induces Epigenetic Silencing of Il2 Gene Expression in Regulatory T Cells

(2012) I. Baine et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and Functional Properties of Helios+ Regulatory T Cells

(2012) Daniel J. Zabransky et al.   PLoS One

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

The microbiome and rheumatoid arthritis

(2011) Jose U. Scher et al.   Nature Reviews Rheumatology

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways

(2010) Jennifer Kearley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dichotomous response to transforming growth factor β after T cell receptor activation by naive CD4+ T cells from DBA/1 mice: Enhanced retinoic acid receptor-related orphan nuclear receptor γt expression yet reduced FoxP3 expression

(2010) Yoshiaki Morita et al.   ARTHRITIS AND RHEUMATISM

Acarbose actions on insulin resistance and inflammatory parameters during an oral fat load

(2010) Giuseppe Derosa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interleukin-9 as a T helper type 17 cytokine

(2010) Elizabeth C. Nowak et al.   IMMUNOLOGY

CCR6 Marks Regulatory T Cells as a Colon-Tropic, IL-10-Producing Phenotype

(2010) K. Kitamura et al.   JOURNAL OF IMMUNOLOGY

Neutralization of IL-9 Ameliorates Experimental Autoimmune Encephalomyelitis by Decreasing the Effector T Cell Population

(2010) H. Li et al.   JOURNAL OF IMMUNOLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

IL-17 as a future therapeutic target for rheumatoid arthritis

(2009) Wim B. van den Berg et al.   Nature Reviews Rheumatology

Type 17 T helper cells—origins, features and possible roles in rheumatic disease

(2009) Francesco Annunziato et al.   Nature Reviews Rheumatology

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Exopolysaccharides Produced by Intestinal Bifidobacterium Strains Act as Fermentable Substrates for Human Intestinal Bacteria

(2008) N. Salazar et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects

(2008) Masayuki Arakawa et al.   METABOLISM-CLINICAL AND EXPERIMENTAL