Electroacupuncture Improved Chronic Cerebral Hypoperfusion-Induced Anxiety-Like Behavior and Memory Impairments in Spontaneously Hypertensive Rats by Downregulating the ACE/Ang II/AT1R Axis and Upregulating the ACE2/Ang-(1-7)/MasR Axis

Changes in blood-brain barrier permeability and ultrastructure, and protein expression in a rat model of cerebral hypoperfusion

(2019) Hema Sekaran et al.   BRAIN RESEARCH BULLETIN

The protective effect of resveratrol on vascular aging by modulation of the renin–angiotensin system

(2018) Eun Nim Kim et al.   ATHEROSCLEROSIS

Within the Brain: The Renin Angiotensin System

(2018) LaDonya Jackson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway

(2018) Ahmed S. Kamel et al.   MOLECULAR NEUROBIOLOGY

HMGB1 Neutralization Attenuates Hippocampal Neuronal Death and Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion via Suppressing Inflammatory Responses and Oxidative Stress

(2018) Yue Hei et al.   NEUROSCIENCE

Acupuncture and electroacupuncture for anxiety disorders: A systematic review of the clinical research

(2018) Diogo Amorim et al.   Complementary Therapies in Clinical Practice

Effect of the Interaction Between Hypertension and Cerebral White Matter Changes on the Progression of Alzheimer Disease

(2018) Ping-Song Chou et al.   Current Alzheimer Research

Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway

(2017) Pei-pei Feng et al.   Evidence-based Complementary and Alternative Medicine

Electroacupuncture Improves Cognitive Deficits through Increasing Regional Cerebral Blood Flow and Alleviating Inflammation in CCI Rats

(2017) Dexiong Han et al.   Evidence-based Complementary and Alternative Medicine

Hypoxia Inducible Factor 1α Promotes Endogenous Adaptive Response in Rat Model of Chronic Cerebral Hypoperfusion

(2017) Ying Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The renin angiotensin system and the brain: New developments

(2017) Ehab Farag et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update

(2017) Tianxin Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

Dynamic Changes in the Renin-Angiotensin-Aldosterone System and the Beneficial Effects of Renin-Angiotensin-Aldosterone Inhibitors on Spatial Learning and Memory in a Rat Model of Chronic Cerebral Ischemia

(2017) Xinwu Huang et al.   Frontiers in Neuroscience

Perindopril Attenuates Lipopolysaccharide-Induced Amyloidogenesis and Memory Impairment by Suppression of Oxidative Stress and RAGE Activation

(2016) Ruby Goel et al.   ACS Chemical Neuroscience

Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice

(2016) Lingxi Wang et al.   EXPERIMENTAL NEUROLOGY

Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?

(2016) Si-Qi Du et al.   MOLECULAR NEUROBIOLOGY

Activation of GABA B2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels

(2016) Yun Lu et al.   NEUROPHARMACOLOGY

Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors

(2016) Lei Wang et al.   NEUROPHARMACOLOGY

Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor

(2016) Wenjuan Wang et al.   PLoS One

Oxiracetam can improve cognitive impairment after chronic cerebral hypoperfusion in rats

(2016) Xiao-li Yao et al.   PSYCHIATRY RESEARCH

Electroacupuncture improves cognitive deficits and activates PPAR-γ in a rat model of Alzheimer's disease

(2016) Min Zhang et al.   Acupuncture in Medicine

Acupuncture attenuates cognitive deficits and increases pyramidal neuron number in hippocampal CA1 area of vascular dementia rats

(2015) Fang Li et al.   BMC Complementary and Alternative Medicine

Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia

(2015) Jun-ichi Ikeda et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Models and mechanisms of vascular dementia

(2015) Poornima Venkat et al.   EXPERIMENTAL NEUROLOGY

Angiotensin-II, the Brain, and Hypertension

(2015) Colin N. Young et al.   HYPERTENSION

Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic StrokeNovelty and Significance

(2015) Douglas M. Bennion et al.   HYPERTENSION

Chronic Cerebral Hypoperfusion Induces Vascular Plasticity and Hemodynamics but Also Neuronal Degeneration and Cognitive Impairment

(2015) Zhen Jing et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region

(2015) Pan Luo et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Interaction between hypertension and cerebral hypoperfusion in the development of cognitive dysfunction and white matter pathology in rats

(2015) J.Y. Choi et al.   NEUROSCIENCE

From Chronic Cerebral Hypoperfusion to Alzheimer-Like Brain Pathology and Neurodegeneration

(2014) Yang Zhao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

(2014) Yang Zhao et al.   Frontiers in Aging Neuroscience

ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke

(2013) Teng Jiang et al.   Current Neuropharmacology

The expression of angiotensin-converting enzyme 2–angiotensin-(1–7)–Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats

(2013) Jie Lu et al.   NEUROPEPTIDES

Possible Role of the Glycogen Synthase Kinase-3 Signaling Pathway in Trimethyltin-Induced Hippocampal Neurodegeneration in Mice

(2013) Juhwan Kim et al.   PLoS One

PI3K/Akt Signal Pathway Involved in the Cognitive Impairment Caused by Chronic Cerebral Hypoperfusion in Rats

(2013) Yi Shu et al.   PLoS One

Cerebral blood flow and metabolic changes in hippocampal regions of a modified rat model with chronic cerebral hypoperfusion

(2012) Hai Jian et al.   ACTA NEUROLOGICA BELGICA

PWZ-029, an inverse agonist selective for α5 GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats

(2012) Marija Milić et al.   BEHAVIOURAL BRAIN RESEARCH

Angiotensin II AT1receptor blockers as treatments for inflammatory brain disorders

(2012) Juan M. Saavedra   CLINICAL SCIENCE

Chronic perfusion of angiotensin II causes cognitive dysfunctions and anxiety in mice

(2012) S. Duchemin et al.   PHYSIOLOGY & BEHAVIOR

Attenuation of Brain Damage and Cognitive Impairment by Direct Renin Inhibition in Mice With Chronic Cerebral Hypoperfusion

(2011) Yi-Fei Dong et al.   HYPERTENSION

The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate

(2010) F. Cechetti et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Effects of early aging and cerebral hypoperfusion on spreading depression in rats

(2009) Eszter Farkas et al.   NEUROBIOLOGY OF AGING

Transient Impairment of Hippocampus-dependent Learning and Memory in Relatively Low-Dose of Acute Radiation Syndrome is Associated with Inhibition of Hippocampal Neurogenesis

(2008) Joong-Sun KIM et al.   JOURNAL OF RADIATION RESEARCH

Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats

(2008) D. Kumaran et al.   NEUROSCIENCE