Role of High‐Density Lipoproteins in Cholesterol Homeostasis and Glycemic Control

Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle

(2019) Shudi Tang et al.   Scientific Reports

Elevated high-density lipoprotein in adolescents with Type 1 diabetes is associated with endothelial dysfunction in the presence of systemic inflammation

(2019) Scott T Chiesa et al.   EUROPEAN HEART JOURNAL

ApoAI-derived peptide increases glucose tolerance and prevents formation of atherosclerosis in mice

(2019) Shelley J. Edmunds et al.   DIABETOLOGIA

Apolipoprotein A-I improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1

(2019) Liming Hou et al.   FASEB JOURNAL

Apolipoprotein A-I Protects Against Pregnancy-Induced Insulin Resistance in Rats

(2019) Ben J. Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dysfunctional HDL and inflammation: a noxious liaison in adolescents with type 1 diabetes

(2019) Philipp Jakob et al.   EUROPEAN HEART JOURNAL

Long-Term Treatment of Niemann-Pick Type C1 Disease With Intrathecal 2-Hydroxypropyl-β-Cyclodextrin

(2018) Elizabeth Berry-Kravis et al.   PEDIATRIC NEUROLOGY

Cytokines and inflammation in adipogenesis: an updated review

(2018) Ning Jiang et al.   Frontiers of Medicine

Insulin resistance: Review of the underlying molecular mechanisms

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis

(2017) Yingke Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study

(2017) Xiaomeng Feng et al.   Lipids in Health and Disease

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Sulforaphane Protects against High Cholesterol-Induced Mitochondrial Bioenergetics Impairments, Inflammation, and Oxidative Stress and Preserves Pancreaticβ-Cells Function

(2017) Catalina Carrasco-Pozo et al.   Oxidative Medicine and Cellular Longevity

The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury

(2017) Fei-Juan Kong et al.   Scientific Reports

Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective

(2016) C. Michael Gibson et al.   CIRCULATION

Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism

(2016) Blake J. Cochran et al.   DIABETES

Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal

(2016) Joan Domingo-Espín et al.   DIABETES

In vivo PET imaging with [18F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes

(2016) Blake J. Cochran et al.   DIABETOLOGIA

Inhibition of inflammatory signaling pathways in 3T3-L1 adipocytes by apolipoprotein A-I

(2016) Afroza Sultana et al.   FASEB JOURNAL

Functional and proteomic alterations of plasma high density lipoproteins in type 1 diabetes mellitus

(2016) Shankarappa Manjunatha et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

(2016) Sebastian Zimmer et al.   Science Translational Medicine

The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies

(2016) Catalina Carrasco-Pozo et al.   Redox Biology

The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice

(2015) Paola Llanos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Investigating the Effect of a Single Infusion of Reconstituted High-Density Lipoprotein in Patients with Symptomatic Carotid Plaques

(2015) Hosaam Nasr et al.   ANNALS OF VASCULAR SURGERY

HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study

(2015) Christiane L. Haase et al.   DIABETES

3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol

(2015) Catalina Carrasco-Pozo et al.   EXPERIMENTAL CELL RESEARCH

Synaptotagmin-7 phosphorylation mediates GLP-1–dependent potentiation of insulin secretion from β-cells

(2015) Bingbing Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infusion of Reconstituted High‐Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial

(2015) Pierluigi Tricoci et al.   Journal of the American Heart Association

Apolipoprotein A-I Increases Insulin Secretion and Production From Pancreatic β-Cells via a G-Protein-cAMP-PKA-FoxO1–Dependent Mechanism

(2014) Blake J. Cochran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Loss-of-Function Mutations inABCA1and Enhanced β-Cell Secretory Capacity in Young Adults

(2014) Michael R. Rickels et al.   DIABETES

HDL cholesterol levels and weight are the main determinants of subclinical atherosclerosis in the young with type 1 diabetes and suitable glycaemic control

(2014) Camila S Pinto et al.   Diabetes & Vascular Disease Research

HDL-C and HDL-C/ApoA-I Predict Long-Term Progression of Glycemia in Established Type 2 Diabetes

(2014) Boris Waldman et al.   DIABETES CARE

Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice

(2014) Karin G. Stenkula et al.   DIABETOLOGIA

Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

(2014) You-Cheol Hwang et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Distinct pathways of cholesterol biosynthesis impact on insulin secretion

(2014) Juan P Zúñiga-Hertz et al.   JOURNAL OF ENDOCRINOLOGY

Effects of High-Density Lipoprotein Elevation With Cholesteryl Ester Transfer Protein Inhibition on Insulin Secretion

(2013) Andrew L. Siebel et al.   CIRCULATION RESEARCH

Apolipoprotein AI and High-Density Lipoprotein Have Anti-Inflammatory Effects on Adipocytes via Cholesterol Transporters

(2013) Tomio Umemoto et al.   CIRCULATION RESEARCH

Role of HDL Cholesterol and Estimates of HDL Particle Composition in Future Development of Type 2 Diabetes in the General Population: The PREVEND Study

(2013) Ali Abbasi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation

(2013) Kristine C. McGrath et al.   JOURNAL OF LIPID RESEARCH

Discoidal HDL and apoA-I-derived peptides improve glucose uptake in skeletal muscle

(2013) Jonathan Dalla-Riva et al.   JOURNAL OF LIPID RESEARCH

HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality

(2013) Julien Puyal et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Skeletal Muscle Insulin Resistance Associated with Cholesterol-Induced Activation of Macrophages Is Prevented by High Density Lipoprotein

(2013) Andrew L. Carey et al.   PLoS One

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking

(2012) Jannick Pétremand et al.   DIABETES

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired  -Cell Function

(2012) J. K. Kruit et al.   DIABETES

Long-term high density lipoprotein infusion ameliorates metabolic phenotypes of diabetic db/db mice

(2012) Qichun Zhang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

AMPK Enhances Insulin-Stimulated GLUT4 Regulation via Lowering Membrane Cholesterol

(2012) Kirk M. Habegger et al.   ENDOCRINOLOGY

Effects of cyclodextrin in two patients with Niemann–Pick Type C disease

(2012) Muneaki Matsuo et al.   MOLECULAR GENETICS AND METABOLISM

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking

(2012) Jonathan S. Bogan et al.   TRAFFIC

The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates β-cell insulin release

(2011) Marie Koren-Gluzer et al.   ATHEROSCLEROSIS

Snapin Mediates Incretin Action and Augments Glucose-Dependent Insulin Secretion

(2011) Woo-Jin Song et al.   Cell Metabolism

Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway

(2011) Xiuli Lu et al.   CELL STRESS & CHAPERONES

Effect of Torcetrapib on Glucose, Insulin, and Hemoglobin A 1c in Subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) Trial

(2011) Philip J. Barter et al.   CIRCULATION

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

(2011) J. K. Kruit et al.   DIABETES

Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle

(2011) K. M. Habegger et al.   DIABETOLOGIA

Cholesterol Elevation Impairs Glucose-Stimulated Ca2+Signaling in Mouse Pancreatic β-Cells

(2011) Andy K. Lee et al.   ENDOCRINOLOGY

Evidence Coupling Increased Hexosamine Biosynthesis Pathway Activity to Membrane Cholesterol Toxicity and Cortical Filamentous Actin Derangement Contributing to Cellular Insulin Resistance†

(2011) Padma Bhonagiri et al.   ENDOCRINOLOGY

Impaired Insulin Secretion in Four Tangier Disease Patients with ABCA1 Mutations

(2011) Masahiro Koseki et al.   Journal of Atherosclerosis and Thrombosis

Type I diabetes mellitus decreases in vivo macrophage-to-feces reverse cholesterol transport despite increased biliary sterol secretion in mice

(2011) Jan Freark de Boer et al.   JOURNAL OF LIPID RESEARCH

High Density Lipoprotein (HDL) Promotes Glucose Uptake in Adipocytes and Glycogen Synthesis in Muscle Cells

(2011) Qichun Zhang et al.   PLoS One

Effects of smoking and smoking cessation on lipids and lipoproteins: Outcomes from a randomized clinical trial

(2010) Adam D. Gepner et al.   AMERICAN HEART JOURNAL

Nonenzymatic Glycation Impairs the Antiinflammatory Properties of Apolipoprotein A-I

(2010) Estelle Nobécourt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of High-Density Lipoproteins on Pancreatic β-Cell Insulin Secretion

(2010) Michelle A. Fryirs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic  -Cell Dysfunction

(2010) M. Vergeer et al.   DIABETES CARE

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

(2010) Jeffrey M. Sturek et al.   JOURNAL OF CLINICAL INVESTIGATION

A First-in-Man, Randomized, Placebo-Controlled Study to Evaluate the Safety and Feasibility of Autologous Delipidated High-Density Lipoprotein Plasma Infusions in Patients With Acute Coronary Syndrome

(2010) Ron Waksman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The β-subunit of ATP synthase is involved in cellular uptake and resecretion of apoA-I but does not control apoA-I-induced lipid efflux in adipocytes

(2010) Alisha D. Howard et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus

(2009) Brian G. Drew et al.   CIRCULATION

Low- and High-Density Lipoproteins Modulate Function, Apoptosis, and Proliferation of Primary Human and Murine Pancreatic β-Cells

(2009) Sabine Rütti et al.   ENDOCRINOLOGY

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

(2009) The Emerging Risk Factors Collaboration*   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice,

(2009) Stephen J. Peterson et al.   JOURNAL OF LIPID RESEARCH

Reconstituted High-Density Lipoprotein Increases Plasma High-Density Lipoprotein Anti-Inflammatory Properties and Cholesterol Efflux Capacity in Patients With Type 2 Diabetes

(2009) Sanjay Patel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chronic Cyclodextrin Treatment of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol and Glycosphingolipid Storage and Disease Progression

(2009) Cristin D. Davidson et al.   PLoS One

Brefeldin A inhibits cholesterol efflux without affecting the rate of cellular uptake and re-secretion of apolipoprotein A-I in adipocytes

(2008) Philip B. Verghese et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reconstituted HDL infusion restores endothelial function in patients with type 2 diabetes mellitus

(2008) M. Nieuwdorp et al.   DIABETOLOGIA

Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-Gated Calcium Channel Function in Pancreatic β-Cells

(2008) Fuzhen Xia et al.   ENDOCRINOLOGY

Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties

(2008) Orit Rozenberg et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

(2008) Mayumi Ishikawa et al.   JOURNAL OF LIPID RESEARCH

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

(2008) Stephen J. Peterson et al.   JOURNAL OF LIPID RESEARCH

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE