Article
Endocrinology & Metabolism
Alexander Becker, Barbara Wardas, Houssein Salah, Maryam Amini, Claudia Fecher-Trost, Qiao Sen, Damian Martus, Andreas Beck, Stephan E. Philipp, Veit Flockerzi, Anouar Belkacemi
Summary: The study revealed that Cav beta 3 interacts with the IP3 receptor in isolated beta-cells independently of Cav channel functions, influencing Ca2+ signaling and regulating insulin expression and glucose-dependent release in a cell-autonomous manner.
Article
Multidisciplinary Sciences
Weidong Zhang, Hideyuki Sakoda, Yuki Nakazato, Md Nurul Islam, Francois Pattou, Julie Kerr-Conte, Masamitsu Nakazato
Summary: NMU, through its receptor NMUR1, impairs insulin secretion in beta cells by affecting mitochondrial function, endoplasmic reticulum stress, and intracellular calcium balance.
Article
Endocrinology & Metabolism
Algerta Marku, Lorenzo Da Dalt, Alessandra Galli, Nevia Dule, Paola Corsetto, Angela Maria Rizzo, Annalisa Moregola, Patrizia Uboldi, Fabrizia Bonacina, Paola Marciani, Michela Castagna, Alberico Luigi Catapano, Giuseppe Danilo Norata, Carla Perego
Summary: This study reveals that pancreatic PCSK9 is a critical regulator of beta-cell function, affecting insulin secretion and cellular function through modulation of cholesterol homeostasis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Pharmacology & Pharmacy
Muhan Jing, Shanshan Wang, Ding Li, Zeyu Wang, Ziwen Li, Yichen Lu, Tong Sun, Chen Qiu, Fang Chen, Haijuan Yu, Wei Zhang
Summary: Lorcaserin, a serotonergic agonist specific to the 5-HT2CR receptor, has shown to suppress insulin secretion by activating 5-HT2CR on beta cells in both in vitro and in vivo models. This study provides valuable insights into the novel signaling mechanism of lorcaserin and its potential clinical applications in the management of obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Louay Bettaieb, Maxime Brule, Axel Chomy, Mel Diedro, Malory Fruit, Eloise Happernegg, Leila Heni, Anais Horochowska, Mahya Housseini, Kekely Klouyovo, Agathe Laratte, Alice Leroy, Paul Lewandowski, Josephine Louvieaux, Amelie Moitie, Remi Tellier, Sofia Titah, Dimitri Vanauberg, Flavie Woesteland, Natalia Prevarskaya, V'yacheslav Lehen'kyi
Summary: Pancreatic adenocarcinoma is a major cause of cancer-related mortality, with Ca2+ signaling playing a crucial role in controlling signaling pathways that promote cancer hallmarks. Understanding and targeting Ca2+ signaling in pancreatic cancer treatment may be a key strategy in overcoming drug resistance and improving outcomes.
Article
Biochemistry & Molecular Biology
Dahae Lee, Young-Mi Kim, Hyun Woo Kim, You-Kyoung Choi, Bang Ju Park, Sang Hoon Joo, Ki Sung Kang
Summary: Schisandrol A and schisandrin C enhanced insulin secretion and glucose uptake, with schisandrin C showing superior effects compared to gliclazide. Treatment with schisandrin C resulted in increased expression of associated proteins in cells, potentially benefiting in improving hyperglycemia.
Article
Plant Sciences
Dahae Lee, Ji-Young Kim, Hak Cheol Kwon, Jaeyoung Kwon, Dae Sik Jang, Ki Sung Kang
Summary: In this study, the potential effects of alpha-Spinasterol, a phytosterol isolated from Aster pseudoglehnii, on glucose uptake and insulin secretion in skeletal muscle cells and pancreatic beta-cells were investigated. The results showed that alpha-Spinasterol enhanced glucose uptake and insulin secretion without causing any toxic effects on the cells. It also increased the expression of proteins related to glucose metabolism. These findings suggest that alpha-Spinasterol could be a potential candidate for the treatment of type 2 diabetes.
Article
Pharmacology & Pharmacy
Hyo-Seon Kim, Dahae Lee, Young-Hye Seo, Seung-Mok Ryu, A-Yeong Lee, Byeong-Cheol Moon, Wook-Jin Kim, Ki-Sung Kang, Jun Lee
Summary: The study aimed to identify bioactive compounds from Angelica reflexa that enhance glucose-stimulated insulin secretion (GSIS) in pancreatic beta-cells. Three new compounds (koseonolin A (1), koseonolin B (2), and isohydroxylomatin (3)) and 28 compounds (4-31) were isolated from the roots of A. reflexa. The effects of the root extract and isolated compounds on GSIS were evaluated, and marmesinin (19) was found to be the most effective, surpassing gliclazide in terms of the improvement of GSIS. The findings suggest that marmesinin (19) has the potential to be used in developing novel therapies for type 2 diabetes.
Review
Biochemistry & Molecular Biology
Anna Weiser, Jerome N. Feige, Umberto De Marchi
Summary: Accumulation of calcium in energized mitochondria of pancreatic beta-cells plays a crucial role in beta-cell function. Mitochondrial calcium signaling is important for regulating insulin secretion and new pharmacological and genetic findings provide potential intervention strategies for modulating pancreatic beta-cell function in the context of diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bernd Coester, Thomas A. Lutz, Christelle Le Foll
Summary: This study suggests that microglial amylin signaling is not a major player in the control of energy homeostasis in mice, as male mice with depleted CTR in microglia did not show significant differences in weight and metabolism compared to mice without depletion.
Article
Environmental Sciences
Xiaoyu Duan, Weijie Sun, Hongwen Sun, Lianying Zhang
Summary: The study revealed that PFASs adversely affect insulin secretion, with exposure to PFOS inhibiting SIRT1 activity and leading to impairment of GSIS.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Jungwon Wee, Sungmin Pak, Tahnbee Kim, Gyu-Sang Hong, Ji Seon Lee, Jinyan Nan, Hyungsup Kim, Mi-Ock Lee, Kyong Soo Park, Uhtaek Oh
Summary: Insulin plays a critical role in regulating glucose homeostasis, while the mechanosensitive channel Tentonin 3/TMEM150C (TTN3) is involved in glucose-stimulated insulin secretion by mediating cation influx in beta-cells.
Article
Biochemistry & Molecular Biology
Veronica A. Cochrane, Zhongying Yang, Mark L. Dell'Acqua, Show-Ling Shyng
Summary: The study revealed that leptin regulates the trafficking of K-ATP channels in pancreatic beta-cells by affecting PKA activity. Increased PKA activity depends on NMDA receptors, CaMKK beta, and AMPK, and is anchored to AKAP79/150 at the cell membrane. disrupting AKAP79/150 coordination may provide a potential target for restoring insulin secretion in beta-cells with defective leptin signaling.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Euiyeon Lee, Keshab Lal Shrestha, Seonhye Kang, Neethu Ramakrishnan, Youngeun Kwon
Summary: This study describes a live cell-based sensor system that can monitor the interaction of EGF and EGFR as well as the subsequent signaling events. The sensor cells are designed based on split-intein-mediated CPC, which translocates the fluorescent cargo to the target cellular location upon the presence of EGF. The sensor cells demonstrate excellent sensitivity and fast response time, and can specifically detect agonists and antagonists of EGFR, as well as monitor downstream signaling cascades.
Article
Food Science & Technology
Yoo Jeong Lee, Gyu Hee Kim, Sang Ick Park, Joo Hyun Lim
Summary: This study investigates the influence of iron and vitamin D on pancreatic beta cell functions and reveals that iron overload reduces VDR levels in beta cells while vitamin D can rescue beta cell dysfunction caused by iron accumulation. The findings suggest an inverse relationship between iron and vitamin D in regulating pancreatic beta cell function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Amy Tse, Lei Yan, Andy K. Lee, Frederick W. Tse
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2012)
Article
Pharmacology & Pharmacy
Nan Wang, Andy K. Lee, Lei Yan, Michael R. Simpson, Amy Tse, Frederick W. Tse
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2012)
Article
Cell Biology
Valerie Yeung-Yam-Wah, Andy K. Lee, Frederick W. Tse, Amy Tse
Article
Cell Biology
Amy Tse, Andy K. Lee, Frederick W. Tse
Article
Cell Biology
Lei Yan, Andy K. Lee, Frederick W. Tse, Amy Tse
Article
Cell Biology
Valerie Yeung-Yam-Wah, Andy K. Lee, Amy Tse
Article
Endocrinology & Metabolism
Andy K. Lee, James L. Smart, Marcelo Rubinstein, Malcolm J. Low, Amy Tse
Article
Biochemistry & Molecular Biology
Amy Tse, Andy K. Lee, Lei Yan, Frederick W. Tse
JOURNAL OF MOLECULAR NEUROSCIENCE
(2012)
Article
Neurosciences
Nan Wang, Christina Kwan, Xiandi Gong, Elena Posse de Chaves, Amy Tse, Frederick W. Tse
JOURNAL OF NEUROSCIENCE
(2010)
Article
Biophysics
Kim San Tang, Nan Wang, Amy Tse, Frederick W. Tse
BIOPHYSICAL JOURNAL
(2007)
Article
Endocrinology & Metabolism
E Hughes, AK Lee, A Tse
Article
Biochemistry & Molecular Biology
JH Xu, FL Xu, FW Tse, A Tse
JOURNAL OF NEUROCHEMISTRY
(2005)
Article
Biochemistry & Molecular Biology
Fenglian Xu, Frederick W. Tse, Amy Tse
JOURNAL OF NEUROCHEMISTRY
(2007)
Article
Cell Biology
FL Xu, JH Xu, FW Tse, A Tse
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2006)