HIV-1 Tat: Role in Bystander Toxicity

HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis

(2019) Palsamy Periyasamy et al.   BRAIN BEHAVIOR AND IMMUNITY

Excess heart age in adult outpatients in routine HIV care

(2019) Angela M. Thompson-Paul et al.   AIDS

Cardiomyocyte–myofibroblast contact dynamism is modulated by connexin-43

(2019) Francisca Schultz et al.   FASEB JOURNAL

Low CD4 cell counts Are Associated with Carotid Plaque and Intima-Medial Thickness in Virologically Suppressed HIV-infected Asians older than 50 years

(2019) Sarawut Siwamogsatham et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans

(2019) Jonathan Buggey et al.   HEART

Risk of myocardial infarction among people living with HIV: an updated systematic review and meta-analysis

(2019) Oghenowede Eyawo et al.   BMJ Open

Cardiovascular risk in HIV-infected patients

(2019) Roberto Palma Reis   Revista Portuguesa de Cardiologia

HIV Infection is Associated with Variability in Ventricular Repolarization: The Multicenter AIDS Cohort Study (MACS)

(2019) Amir S. Heravi et al.   CIRCULATION

New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System

(2019) Victoria Rojas-Celis et al.   Cells

Endothelial mitochondrial senescence accelerates cardiovascular disease in antiretroviral-receiving HIV patients

(2019) Yi-Fan Chen et al.   TOXICOLOGY LETTERS

Microtubule cytoskeleton regulates Connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene

(2018) Coline Macquart et al.   HUMAN MOLECULAR GENETICS

The role of HIV Tat protein in HIV-related cardiovascular diseases

(2018) Yanan Jiang et al.   Journal of Translational Medicine

HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies

(2018) Kaori Asamitsu et al.   MOLECULES

Intercalated discs: cellular adhesion and signaling in heart health and diseases

(2018) Guangze Zhao et al.   HEART FAILURE REVIEWS

“cART intensification by the HIV-1 Tat B clade vaccine: progress to phase III efficacy studies”

(2017) Aurelio Cafaro et al.   Expert Review of Vaccines

Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes

(2017) Farzaneh G. Tahrir et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND

(2017) Guoku Hu et al.   Journal of Neuroimmune Pharmacology

Tsg101 chaperone function revealed by HIV-1 assembly inhibitors

(2017) Madeleine Strickland et al.   Nature Communications

Tat is a multifunctional viral protein that modulates cellular gene expression and functions

(2017) Evan Clark et al.   Oncotarget

HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations

(2017) Doreen Kamori et al.   Frontiers in Microbiology

The Molecular Basis for Human Immunodeficiency Virus Latency

(2017) Uri Mbonye et al.   Annual Review of Virology

miR-34a is a common link in both HIV- and antiretroviral therapy-induced vascular aging

(2016) Jiaxin Zhan et al.   Aging-US

Recent advances in the identification of Tat-mediated transactivation inhibitors: progressing toward a functional cure of HIV

(2016) Oriana Tabarrini et al.   Future Medicinal Chemistry

HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS

(2016) Joan W. Berman et al.   Journal of Neuroinflammation

Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy

(2016) Nath Zungsontiporn et al.   PLoS One

Increased cardiovascular disease risk in the HIV-positive population on ART: potential role of HIV-Nef and Tat

(2015) Ting Wang et al.   CARDIOVASCULAR PATHOLOGY

HIV-1 TAT and IMMUNE DYSREGULATION in AIDS PATHOGENESIS: a THERAPEUTIC TARGET

(2015) Chiara Chiozzini et al.   CURRENT DRUG TARGETS

HIV-1 Tat-Mediated Calcium Dysregulation and Neuronal Dysfunction in Vulnerable Brain Regions

(2015) Xiu-Ti Hu   CURRENT DRUG TARGETS

Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders

(2015) Jerel Fields et al.   CURRENT HIV RESEARCH

HIV Extracellular Tat: Myth or Reality?

(2015) Erwann Loret   CURRENT HIV RESEARCH

HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes

(2015) Gi Soo Youn et al.   GLIA

Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain

(2015) Joni M. Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV Tat protein: Is Tat-C much trickier than Tat-B?

(2015) Manish Kumar Johri et al.   JOURNAL OF MEDICAL VIROLOGY

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy

(2015) Ersilia Cipolletta et al.   PLoS One

Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent manner

(2014) Chiara Chiozzini et al.   AIDS

Structural biology of Tat protein transport

(2014) Ben C Berks et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

HIV-1 target cells in the CNS

(2014) Sarah B. Joseph et al.   JOURNAL OF NEUROVIROLOGY

Immunologic strategies for HIV-1 remission and eradication

(2014) D. H. Barouch et al.   SCIENCE

Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND)

(2014) Vasudev R Rao et al.   AIDS Research and Therapy

Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection

(2013) Tricia H. Burdo et al.   AIDS

Detection of anti-tat antibodies in CSF of individuals with HIV-associated neurocognitive disorders

(2013) M. Bachani et al.   JOURNAL OF NEUROVIROLOGY

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer

(2013) Jerel Fields et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

Past, present and future: 30 years of HIV research

(2013) Françoise Barré-Sinoussi et al.   NATURE REVIEWS MICROBIOLOGY

Molecular and pathologic insights from latent HIV-1 infection in the human brain

(2013) P. Desplats et al.   NEUROLOGY

Mechanisms of HIV Entry into the CNS: Increased Sensitivity of HIV Infected CD14+CD16+ Monocytes to CCL2 and Key Roles of CCR2, JAM-A, and ALCAM in Diapedesis

(2013) Dionna W. Williams et al.   PLoS One

Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence

(2013) Vasudev R Rao et al.   Retrovirology

Roles and functions of HIV-1 Tat protein in the CNS: an overview

(2013) Asen Bagashev et al.   Virology Journal

Functional HIV cure is no pipe dream, says codiscoverer of the virus

(2013) G. Watts   BMJ-British Medical Journal

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression

(2013) J. Karn et al.   Cold Spring Harbor Perspectives in Medicine

HIV Pathogenesis: The Host

(2013) A. A. Lackner et al.   Cold Spring Harbor Perspectives in Medicine

Control of HIV Latency by Epigenetic and Non-Epigenetic Mechanisms

(2012) Jonathan Karn et al.   CURRENT HIV RESEARCH

MiR-34a is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation through the SIRT1/NFκB pathway

(2012) Hong-Sheng Zhang et al.   FEBS LETTERS

Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat

(2012) Jun Yong Choi et al.   JOURNAL OF NEUROVIROLOGY

The Viral Protein Tat Can Inhibit the Establishment of HIV-1 Latency

(2012) D. A. Donahue et al.   JOURNAL OF VIROLOGY

Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory

(2012) Gladys Chompre et al.   NEUROBIOLOGY OF DISEASE

HIV-1 Tat Promotes Integrin-Mediated HIV Transmission to Dendritic Cells by Binding Env Spikes and Competes Neutralization by Anti-HIV Antibodies

(2012) Paolo Monini et al.   PLoS One

Extracellular HIV-1 Tat upregulates TNF-α dependent MCP-1/CCL2 production via activation of ERK1/2 pathway in rat hippocampal slice cultures: Inhibition by resveratrol, a polyphenolic phytostilbene

(2011) Eun Ok Lee et al.   EXPERIMENTAL NEUROLOGY

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

(2011) Claire Séror et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIV-1 Clade B and C Isolates Exhibit Differential Replication: Relevance to Macrophage-Mediated Neurotoxicity

(2011) Agnes A. Constantino et al.   NEUROTOXICITY RESEARCH

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

Contemporary costs of HIV healthcare in the HAART era

(2010) Kelly A Gebo et al.   AIDS

Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration

(2010) H. Yao et al.   BLOOD

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

(2010) Fabienne Rayne et al.   EMBO JOURNAL

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

(2010) Jonathan Karn   Current Opinion in HIV and AIDS

Differential Effects of HIV Type 1 Clade B and Clade C Tat Protein on Expression of Proinflammatory and Antiinflammatory Cytokines by Primary Monocytes

(2009) Nimisha Gandhi et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Chromatin dynamics associated with HIV-1 Tat-activated transcription

(2009) Rebecca Easley et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Vascular risk factors, HIV serostatus, and cognitive dysfunction in gay and bisexual men

(2009) J. T. Becker et al.   NEUROLOGY

Human Immunodeficiency Virus (HIV) Infects Human Arterial Smooth Muscle Cells in Vivo and in Vitro

(2008) Eliseo A. Eugenin et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuronal survival and resistance to HIV-1 Tat toxicity in the primary culture of rat fetal neurons

(2008) Marina V. Aksenova et al.   EXPERIMENTAL NEUROLOGY

NMDA Receptor Activation by HIV-Tat Protein Is Clade Dependent

(2008) W. Li et al.   JOURNAL OF NEUROSCIENCE

HIV-1 Clade-Specific Differences in the Induction of Neuropathogenesis

(2008) V. R. Rao et al.   JOURNAL OF NEUROSCIENCE

The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription

(2008) Chiara Vardabasso et al.   Retrovirology

Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif

(2007) Mamata Mishra et al.   ANNALS OF NEUROLOGY