HIV-1 Tat Promotes Integrin-Mediated HIV Transmission to Dendritic Cells by Binding Env Spikes and Competes Neutralization by Anti-HIV Antibodies

A combination HIV vaccine based on Tat and Env proteins was immunogenic and protected macaques from mucosal SHIV challenge in a pilot study

(2011) Flavia Ferrantelli et al.   VACCINE

The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates

(2010) Abhinav P. Acharya et al.   BIOMATERIALS

Impact of Viral Dose and Major Histocompatibility Complex Class IB Haplotype on Viral Outcome in Mauritian Cynomolgus Monkeys Vaccinated with Tat upon Challenge with Simian/Human Immunodeficiency Virus SHIV89.6P

(2010) A. Cafaro et al.   JOURNAL OF VIROLOGY

Targeting early infection to prevent HIV-1 mucosal transmission

(2010) Ashley T. Haase   NATURE

Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART

(2010) Barbara Ensoli et al.   PLoS One

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Immobilized HIV-1 Tat protein promotes gene transfer via a transactivation-independent mechanism which requires binding of Tat to viral particles

(2009) Filomena Nappi et al.   JOURNAL OF GENE MEDICINE

HIV-1 Tat Addresses Dendritic Cells to Induce a Predominant Th1-Type Adaptive Immune Response That Appears Prevalent in the Asymptomatic Stage of Infection

(2009) E. Fanales-Belasio et al.   JOURNAL OF IMMUNOLOGY

Phase I therapeutic trial of the HIV-1 Tat protein and long term follow-up

(2009) Olimpia Longo et al.   VACCINE

The preventive phase I trial with the HIV-1 Tat-based vaccine

(2009) Barbara Ensoli et al.   VACCINE

Containment of Infection in Tat Vaccinated Monkeys After Rechallenge with a Higher Dose of SHIV89.6Pcy243

(2009) Alessandra Borsetti et al.   VIRAL IMMUNOLOGY

The therapeutic phase I trial of the recombinant native HIV-1 Tat protein

(2008) Barbara Ensoli et al.   AIDS

The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: Implications for the design of new vaccination strategies against AIDS

(2007) Riccardo Gavioli et al.   VACCINE