African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity

Neutrophils in tissue injury and repair

(2018) Jing Wang   CELL AND TISSUE RESEARCH

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

(2018) Simone Joas et al.   Nature Communications

The Dual Role of Neutrophils in HIV Infection

(2018) Tiffany Hensley-McBain et al.   Current HIV/AIDS Reports

Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis

(2018) Hiroko Oshima et al.   FASEB JOURNAL

Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host

(2018) David Palesch et al.   NATURE

Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates

(2018) Ranjit Sivanandham et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathogenic Correlates of Simian Immunodeficiency Virus-Associated B Cell Dysfunction

(2017) Egidio Brocca-Cofano et al.   JOURNAL OF VIROLOGY

Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation

(2017) Rajesh T. Gandhi et al.   PLoS Pathogens

Pathobiology of neutrophil-epithelial interactions

(2016) Jennifer C. Brazil et al.   IMMUNOLOGICAL REVIEWS

The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that may contribute to protection from disease progression

(2016) Kevin Raehtz et al.   INFECTION GENETICS AND EVOLUTION

Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function

(2016) Alyssa Mitson-Salazar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gut Mucosal Barrier Dysfunction, Microbial Dysbiosis, and Their Role in HIV-1 Disease Progression

(2016) Joseph C. Mudd et al.   JOURNAL OF INFECTIOUS DISEASES

Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication

(2016) Adam J. Ericsen et al.   PLoS Pathogens

Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers

(2016) Benjamin B. Policicchio et al.   PLoS Pathogens

Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques

(2016) Ivona Pandrea et al.   PLoS Pathogens

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

(2016) Odile Wéra et al.   Journal of Clinical Medicine

Role of intestinal myofibroblasts in HIV-associated intestinal collagen deposition and immune reconstitution following combination antiretroviral therapy

(2015) David M. Asmuth et al.   AIDS

Gut epithelial barrier and systemic inflammation during chronic HIV infection

(2015) Ma Somsouk et al.   AIDS

Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis

(2015) Bosi Yuan et al.   Gut and Liver

Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation

(2015) Joseph M. Reynolds et al.   IMMUNITY

Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues

(2015) Tianyu He et al.   JOURNAL OF VIROLOGY

Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research

(2015) Dongzhu Ma et al.   JOURNAL OF VIROLOGY

Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV

(2015) Sarah T. C. Elliott et al.   JOURNAL OF VIROLOGY

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

(2015) Xing Pei Hao et al.   Nature Communications

Using the Pathogenic and Nonpathogenic Nonhuman Primate Model for Studying Non-AIDS Comorbidities

(2015) Ivona Pandrea et al.   Current HIV/AIDS Reports

Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication

(2014) Jan Kristoff et al.   JOURNAL OF CLINICAL INVESTIGATION

The Myeloid Differentiation Factor 88 (MyD88) Is Required for CD4+ T Cell Effector Function in a Murine Model of Inflammatory Bowel Disease

(2014) M. Fukata et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

(2014) I. Pandrea et al.   JOURNAL OF IMMUNOLOGY

Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques

(2014) J. D. Estes et al.   JOURNAL OF IMMUNOLOGY

Antifibrotic Therapy in Simian Immunodeficiency Virus Infection Preserves CD4+ T-Cell Populations and Improves Immune Reconstitution With Antiretroviral Therapy

(2014) Jacob D. Estes et al.   JOURNAL OF INFECTIOUS DISEASES

Deep Transcriptional Sequencing of Mucosal Challenge Compartment from Rhesus Macaques Acutely Infected with Simian Immunodeficiency Virus Implicates Loss of Cell Adhesion Preceding Immune Activation

(2014) Fredrik Barrenas et al.   JOURNAL OF VIROLOGY

Pathogenic Features Associated with Increased Virulence upon Simian Immunodeficiency Virus Cross-Species Transmission from Natural Hosts

(2014) D. T. Mandell et al.   JOURNAL OF VIROLOGY

Factors Associated with Siman Immunodeficiency Virus Transmission in a Natural African Nonhuman Primate Host in the Wild

(2014) D. Ma et al.   JOURNAL OF VIROLOGY

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Virus–host mucosal interactions during early SIV rectal transmission

(2014) Wuxun Lu et al.   VIROLOGY

Vaginal Challenge with an SIV-Based Dual Reporter System Reveals That Infection Can Occur throughout the Upper and Lower Female Reproductive Tract

(2014) Daniel J. Stieh et al.   PLoS Pathogens

Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or Not with Interferon-Alpha during Primary SIVagm Infection

(2014) Béatrice Jacquelin et al.   PLoS Pathogens

Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption

(2014) Lauren A. Hirao et al.   PLoS Pathogens

Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals

(2014) Nichole R. Klatt et al.   PLoS Pathogens

Microbial Translocation in the Pathogenesis of HIV Infection and AIDS

(2013) Giulia Marchetti et al.   CLINICAL MICROBIOLOGY REVIEWS

Systemic Effects of Inflammation on Health during Chronic HIV Infection

(2013) Steven G. Deeks et al.   IMMUNITY

Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues

(2013) Jacob D. Estes   IMMUNOLOGICAL REVIEWS

Deletion of Intestinal Epithelial Cell STAT3 Promotes T-Lymphocyte STAT3 Activation and Chronic Colitis Following Acute Dextran Sodium Sulfate Injury in Mice

(2013) Tara A. Willson et al.   INFLAMMATORY BOWEL DISEASES

Loss of memory CD4+ T-cells in semi-wild mandrills (Mandrillus sphinx) naturally infected with species-specific simian immunodeficiency virus SIVmnd-1

(2013) E. J. D. Greenwood et al.   JOURNAL OF GENERAL VIROLOGY

Rate of AIDS Progression Is Associated with Gastrointestinal Dysfunction in Simian Immunodeficiency Virus-Infected Pigtail Macaques

(2013) L. A. Canary et al.   JOURNAL OF IMMUNOLOGY

Mx Proteins: Antiviral Gatekeepers That Restrain the Uninvited

(2013) J. Verhelst et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Convergence and Divergence in the Evolution of the APOBEC3G-Vif Interaction Reveal Ancient Origins of Simian Immunodeficiency Viruses

(2013) Alex A. Compton et al.   PLoS Pathogens

SIVagm Infection in Wild African Green Monkeys from South Africa: Epidemiology, Natural History, and Evolutionary Considerations

(2013) Dongzhu Ma et al.   PLoS Pathogens

Macaques as model hosts for studies of HIV-1 infection

(2013) Anisha Misra et al.   Frontiers in Microbiology

Microbial Translocation Across the GI Tract

(2012) Jason M. Brenchley et al.   Annual Review of Immunology

Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates

(2012) I. Pandrea et al.   BLOOD

Mucosal Simian Immunodeficiency Virus Transmission in African Green Monkeys: Susceptibility to Infection Is Proportional to Target Cell Availability at Mucosal Sites

(2012) Ivona Pandrea et al.   JOURNAL OF VIROLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Microbial translocation in HIV infection: causes, consequences and treatment opportunities

(2012) Netanya G. Sandler et al.   NATURE REVIEWS MICROBIOLOGY

Natural SIV Hosts: Showing AIDS the Door

(2012) Ann Chahroudi et al.   SCIENCE

Microbial translocation, immune activation, and HIV disease

(2012) Nichole R. Klatt et al.   TRENDS IN MICROBIOLOGY

Increased Platelet and Microparticle Activation in HIV Infection

(2011) Elizabeth Mayne et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Dynamics of Simian Immunodeficiency Virus SIVmac239 Infection in Pigtail Macaques

(2011) N. R. Klatt et al.   JOURNAL OF VIROLOGY

Immunovirological Analyses of Chronically Simian Immunodeficiency Virus SIVmnd-1- and SIVmnd-2-Infected Mandrills (Mandrillus sphinx)

(2011) C. Apetrei et al.   JOURNAL OF VIROLOGY

CD4-Like Immunological Function by CD4- T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

(2011) C. Vinton et al.   JOURNAL OF VIROLOGY

Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

(2011) Mirko Paiardini et al.   NATURE MEDICINE

Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4+ T Cells and Is Reverted by CD8+ Cell Depletion

(2011) Ivona Pandrea et al.   PLoS Pathogens

Non-Invasive Markers for Early Diagnosis and Determination of the Severity of Necrotizing Enterocolitis

(2010) Geertje Thuijls et al.   ANNALS OF SURGERY

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease

(2010) R. C. Zahn et al.   BLOOD

Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10

(2010) Yoshiyasu Ueda et al.   INTERNATIONAL IMMUNOLOGY

Disruption of Intestinal CD4+ T Cell Homeostasis Is a Key Marker of Systemic CD4+ T Cell Activation in HIV-Infected Individuals

(2010) S. N. Gordon et al.   JOURNAL OF IMMUNOLOGY

Pattern of SIVagm Infection in Patas Monkeys Suggests that Host Adaptation to Simian Immunodeficiency Virus Infection May Result in Resistance to Infection and Virus Extinction

(2010) Cristian Apetrei et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent Microbial Translocation and Immune Activation in HIV‐1–Infected South Africans Receiving Combination Antiretroviral Therapy

(2010) Edana Cassol et al.   JOURNAL OF INFECTIOUS DISEASES

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase

(2010) Kiran D. Mir et al.   MICROBES AND INFECTION

Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation and IL-17 production in the absence of SIV infection

(2010) N R Klatt et al.   Mucosal Immunology

Island Biogeography Reveals the Deep History of SIV

(2010) M. Worobey et al.   SCIENCE

A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo

(2010) Nadeene E. Riddick et al.   PLoS Pathogens

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

(2010) Jacob D. Estes et al.   PLoS Pathogens

The Great Escape: Viral Strategies to Counter BST-2/Tetherin

(2010) Janet L. Douglas et al.   PLoS Pathogens

Where the Wild Things Are: Pathogenesis of SIV Infection in African Nonhuman Primate Hosts

(2010) Ivona Pandrea et al.   Current HIV/AIDS Reports

Globally optimal stitching of tiled 3D microscopic image acquisitions

(2009) S. Preibisch et al.   BIOINFORMATICS

AIDS in African Nonhuman Primate Hosts of SIVs: A New Paradigm of SIV Infection

(2009) Ivona Pandrea et al.   CURRENT HIV RESEARCH

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Apoptosis and cancer: mutations within caspase genes

(2009) S Ghavami et al.   JOURNAL OF MEDICAL GENETICS

High Specific Infectivity of Plasma Virus from the Pre-Ramp-Up and Ramp-Up Stages of Acute Simian Immunodeficiency Virus Infection

(2009) Z.-M. Ma et al.   JOURNAL OF VIROLOGY

Simian Immunodeficiency Virus SIVagm from African Green Monkeys Does Not Antagonize Endogenous Levels of African Green Monkey Tetherin/BST-2

(2009) E. S. Lim et al.   JOURNAL OF VIROLOGY

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

(2009) Coreen M Beaumier et al.   NATURE MEDICINE

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

(2009) Donald L Sodora et al.   NATURE MEDICINE

Transcriptional Profiling in Pathogenic and Non-Pathogenic SIV Infections Reveals Significant Distinctions in Kinetics and Tissue Compartmentalization

(2009) Sharon Lederer et al.   PLoS Pathogens

Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys

(2009) Jörn E. Schmitz et al.   PLoS Pathogens

Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species

(2008) Marc Meier et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Intestinal fibrosis in inflammatory bowel disease — Current knowledge and future perspectives

(2008) Florian Rieder et al.   Journal of Crohns & Colitis

Collagen Deposition Limits Immune Reconstitution in the Gut

(2008) Jacob Estes et al.   JOURNAL OF INFECTIOUS DISEASES

Simian Immunodeficiency Virus–Induced Intestinal Cell Apoptosis Is the Underlying Mechanism of the Regenerative Enteropathy of Early Infection

(2008) Qingsheng Li et al.   JOURNAL OF INFECTIOUS DISEASES

Plasmacytoid Dendritic Cell Dynamics and Alpha Interferon Production during Simian Immunodeficiency Virus Infection with a Nonpathogenic Outcome

(2008) O. M. Diop et al.   JOURNAL OF VIROLOGY

Paucity of CD4+ CCR5+ T Cells May Prevent Transmission of Simian Immunodeficiency Virus in Natural Nonhuman Primate Hosts by Breast-Feeding

(2008) I. Pandrea et al.   JOURNAL OF VIROLOGY

Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys

(2008) I. Pandrea et al.   JOURNAL OF VIROLOGY

A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution

(2008) R. J. Gifford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts

(2008) Ivona Pandrea et al.   TRENDS IN IMMUNOLOGY

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE