Article
Economics
Matthijs M. Versteegh, Simone A. Huygens, Beatrijs W. H. Wokke, Joost Smolders
Summary: This study compared 360 different treatment sequences for patients with relapsing-remitting multiple sclerosis (RRMS) in terms of health outcomes and societal costs. The results showed that the optimal treatment sequence for maximizing health outcomes was not necessarily the most cost-effective option. Treatment decisions should be individually tailored.
Article
Clinical Neurology
Brandi L. Vollmer, Andrew B. Wolf, Stefan Sillau, John R. Corboy, Enrique Alvarez
Summary: This study discusses the sequencing strategies for disease modifying therapies (DMTs) in multiple sclerosis (MS) patients and proposes a de-escalation approach to balance the benefit and risk in aging patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Georges Jalkh, Rachelle Abi Nahed, Gabrielle Macaron, Mary Rensel
Summary: In the past decade, the therapeutic options for multiple sclerosis have greatly expanded, with newer and more effective disease modifying therapies being increasingly used early in the disease course. Despite their advantages in controlling disease activity and improving long-term outcomes, these newer therapies come with safety concerns and monitoring requirements that highlight the need for periodic re-evaluation and adjustment of monitoring strategies for optimizing treatment safety in an individualized manner.
Review
Clinical Neurology
Francesca Washington, Dawn Langdon
Summary: Research shows that patients with multiple sclerosis often struggle with treatment adherence, influenced by factors such as age, gender, emotions, cognition, and treatment satisfaction. Targeted patient support programs should be developed to improve treatment compliance.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Steve Simpson-Yap, Edward De Brouwer, Tomas Kalincik, Nick Rijke, Jan A. Hillert, Clare Walton, Gilles Edan, Yves Moreau, Tim Spelman, Lotte Geys, Tina Parciak, Clement Gautrais, Nikola Lazovski, Ashkan Pirmani, Amin Ardeshirdavanai, Lars Forsberg, Anna Glaser, Robert McBurney, Hollie Schmidt, Arnfin B. Bergmann, Stefan Braune, Alexander Stahmann, Rodden Middleton, Amber Salter, Robert J. Fox, Anneke van der Walt, Helmut Butzkueven, Raed Alroughani, Serkan Ozakbas, Juan Rojas, Ingrid van der Mei, Nupur Nag, Rumen Ivanov, Guilherme Sciascia do Olival, Alice Estavo Dias, Melinda Magyari, Doralina Brum, Maria Fernanda Mendes, Ricardo N. Alonso, Richard S. Nicholas, Johana Bauer, Anibal Sebastian Chertcoff, Anna Zabalza, Georgina Arrambide, Alexander Fidao, Giancarlo Comi, Liesbet Peeters
Summary: Using data from 12 sources in 28 countries, this study examined the characteristics of COVID-19 severity in people with MS, particularly those taking immunosuppressive therapies. The results showed that older age, progressive MS phenotype, and higher disability were associated with worse COVID-19 outcomes. Additionally, rituximab was consistently associated with increased risk of hospitalization, ICU admission, and need for ventilation, while ocrelizumab was mainly associated with hospitalization and ICU admission.
Article
Clinical Neurology
J. Hillen, M. Ward, M. Slee, T. Stanford, E. Roughead, L. Kalisch Ellett, N. Pratt
Summary: This study evaluated the utilization and treatment patterns of disease modifying treatments (DMTs) for relapsing remitting multiple sclerosis (RRMS) using a representative sample of Australian pharmaceutical benefits scheme data. The results showed that the availability of new DMTs influenced both initial treatment choice and prevalence of users, and individualized treatment patterns and exposure to multiple medicines over time will challenge traditional pharmacovigilance systems.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Line Broch, Heidi Oyen Flemmen, Cecilia Smith Simonsen, Pal Berg-Hansen, Heidi Ormstad, Cathrine Brunborg, Elisabeth Gulowsen Celius
Summary: This study investigated the relationship between the use of disease-modifying treatment and fatigue in patients with multiple sclerosis. The results showed that there was no independent relationship between the use of disease-modifying treatment and fatigue.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Melanie Korsen, Steffen Pfeuffer, Leoni Rolfes, Sven G. Meuth, Hans-Peter Hartung
Summary: A critical issue in the management of relapsing MS is the discontinuation of disease-modifying treatments due to lack of efficacy, intolerability or impending risks. This study provides an overview of real-world evidence on the effectiveness and safety of switching from fingolimod to another DMT in patients with active RMS. The evidence suggests that some therapeutic agents may increase the risk of relapse and worsening disability in patients switching from fingolimod compared to those switching from other agents.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Roberta Amoriello, Roberta Rizzo, Alice Mariottini, Daria Bortolotti, Valentina Gentili, Elena Bonechi, Alessandra Aldinucci, Alberto Carnasciali, Benedetta Peruzzi, Anna Maria Repice, Luca Massacesi, Enrico Fainardi, Clara Ballerini
Summary: Relapsing-remitting multiple sclerosis (RRMS) is associated with the HLA-G gene, which may play a role in regulating the disease. The study found that serum sHLA-G level is influenced by genotype and has an impact on treatment and MRI activity, but is not correlated with peripheral inflammation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Pietro Iaffaldano, Giuseppe Lucisano, Francesca Caputo, Damiano Paolicelli, Francesco Patti, Mauro Zaffaroni, Vincenzo Brescia Morra, Carlo Pozzilli, Giovanna De Luca, Matilde Inglese, Giuseppe Salemi, Giorgia Teresa Maniscalco, Eleonora Cocco, Patrizia Sola, Giacomo Lus, Antonella Conte, Maria Pia Amato, Franco Granella, Claudio Gasperini, Paolo Bellantonio, Rocco Totaro, Marco Rovaris, Marco Salvetti, Valentina Liliana Adriana Torri Clerici, Roberto Bergamaschi, Davide Maimone, Elio Scarpini, Marco Capobianco, Giancarlo Comi, Massimo Filippi, Maria Trojano
Summary: The study showed that early intensive treatment was more effective in controlling disability progression over time compared to starting with moderate-efficacy treatment and escalating to higher-efficacy therapy in patients with relapsing-remitting multiple sclerosis.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Clinical Neurology
Mikhail Melnikov, Dmitriy Kasatkin, Anna Lopatina, Nikolay Spirin, Alexey Boyko, Mikhail Pashenkov
Summary: Investigation of neuroimmune interactions is one of the most developing areas in multiple sclerosis pathogenesis research. Recent evidence suggests that neuroinflammation can be modulated by targeting biogenic amine receptors. Selective serotonin reuptake inhibitor fluoxetine has been shown to modulate the function of innate and adaptive immune system cells and reduce the severity of experimental autoimmune encephalomyelitis and multiple sclerosis. Retrospective data suggests that fluoxetine could be considered an additional therapy to the standard first-line disease-modifying treatment for relapsing-remitting multiple sclerosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Franz Felix Konen, Nora Moehn, Torsten Witte, Matthias Schefzyk, Miriam Wiestler, Svjetlana Lovric, Karsten Hufendiek, Philipp Schwenkenbecher, Kurt-Wolfram Suehs, Manuel A. Friese, Luisa Klotz, Refik Pul, Marc Pawlitzki, David Hagin, Christoph Kleinschnitz, Sven G. Meuth, Thomas Skripuletz
Summary: More than 10 disease-modifying therapies (DMT) have been approved for the treatment of multiple sclerosis (MS), and new therapeutic options are emerging. The individualized selection of DMTs in MS is possible due to different therapeutic mechanisms. The treatment of comorbid autoimmune disorders should be considered, as DMTs can also treat concomitant inflammatory diseases but may lead to exacerbation of autoimmune diseases.
AUTOIMMUNITY REVIEWS
(2023)
Review
Clinical Neurology
F. Schweitzer, S. Laurent, G. R. Fink, Michael H. Barnett, H. P. Hartung, C. Warnke
Summary: This review summarizes the predicted and unintended adverse effects of disease-modifying therapies for multiple sclerosis on leukocytes in peripheral blood, highlighting the importance of vigilance for potential therapeutic risks when prescribing medications.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Hans-Peter Hartung, Sven G. Meuth, Deborah M. Miller, Giancarlo Comi
Summary: The review assesses the reasons for considering discontinuation of disease-modifying therapies in MS patients, finding that stopping treatment may be feasible for older individuals with stable disease. Prognostic factors have been identified, and several clinical scenarios provide rationale for stopping treatment. Recent evidence allows for a more precise weighing of risks against benefits.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Clinical Neurology
Massimo Filippi, Maria Pia Amato, Diego Centonze, Paolo Gallo, Claudio Gasperini, Matilde Inglese, Francesco Patti, Carlo Pozzilli, Paolo Preziosa, Maria Trojano
Summary: Early intervention with high-efficacy disease-modifying therapies (HE-DMTs) can significantly reduce inflammation and disease progression in patients with multiple sclerosis (MS), with acceptable long-term safety risks.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Brenda Banwell, Jeffrey L. Bennett, Romain Marignier, Ho Jin Kim, Fabienne Brilot, Eoin P. Flanagan, Sudarshini Ramanathan, Patrick Waters, Silvia Tenembaum, Jennifer S. Graves, Tanuja Chitnis, Alexander U. Brandt, Cheryl Hemingway, Rinze Neuteboom, Lekha Pandit, Markus Reindl, Albert Saiz, Douglas Kazutoshi Sato, Kevin Rostasy, Friedemann Paul, Sean J. Pittock, Kazuo Fujihara, Jacqueline Palace
Summary: Serum antibodies against MOG can help diagnose MOGAD, which is distinct from multiple sclerosis and neuromyelitis optica. The presence of MOG-IgG is a core criterion for the diagnosis. MOGAD can present with various symptoms and can be either monophasic or relapsing, and diagnostic accuracy relies on MOG-IgG cell-based assays.
Article
Clinical Neurology
Josephine Heine, Ankelien Duchow, Rebekka Rust, Friedemann Paul, Harald Pruess, Carsten Finke
Summary: Detection of autoantibodies against neurons and glia cells allows for early and specific diagnosis of autoimmune encephalitis, leading to changes in treatment algorithms and understanding of disease mechanisms. Continuous updates on antibody diagnostics, associated tumors, and clinical spectrum are necessary due to increasing numbers of new autoantibodies. This article summarizes recent developments in clinical presentations, diagnostic methods, prognostic markers, and immunotherapies for autoimmune encephalitis.
Article
Clinical Neurology
Martin W. Huemmert, Franziska Buetow, Daria Tkachenko, Ilya Ayzenberg, Thivya Pakeerathan, Kerstin Hellwig, Luisa Klotz, Vivien Haeussler, Jan-Patrick Stellmann, Clemens Warnke, Yasemin Goereci, Thorleif Etgen, Felix Luessi, Paul Bronzlik, Stefan Gingele, Ann-Sophie Lauenstein, Ingo Kleiter, Paulus S. Rommer, Friedemann Paul, Judith Bellmann-Strobl, Ankelien Duchow, Florian Then Bergh, Refik Pul, Annette Walter, Hannah Pellkofer, Tania Kuempfel, Mosche Pompsch, Markus Kraemer, Philipp Albrecht, Orhan Aktas, Marius Ringelstein, Makbule Senel, Katrin Giglhuber, Achim Berthele, Sven Jarius, Brigitte Wildemann, Corinna Trebst
Summary: This study evaluated the impact of the COVID-19 pandemic on the lives of patients with NMOSD and MOGAD. It found that most patients had continued access to healthcare services and were satisfied with medical care during the pandemic. Their health-related quality of life did not decline.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Neurosciences
Kamil Sebastian Rosiewicz, Bakhrom Muinjonov, Severine Kunz, Helena Radbruch, Jessy Chen, Rene Juettner, Janis Kerkering, Julia Ucar, Tadhg Crowley, Ben Wielockx, Friedemann Paul, Marlen Alisch, Volker Siffrin
Summary: Astrocytes play a crucial role in maintaining the blood-brain barrier and supporting neuronal functions. In this study, transgenic mice with astrocyte-specific activation of the hypoxia-response program were investigated. The deletion of oxygen sensors in these mice led to an exacerbation of autoimmune encephalomyelitis, accompanied by immune cell infiltration. The study also highlighted the loss of gap-junctional Connexin-43 in these astrocytes, which was induced by vascular endothelial growth factor-alpha expression.
Article
Plant Sciences
Virunh Kongkatitham, Adeline Dehlinger, Meng Wang, Preeyaporn Poldorn, Carl Weidinger, Marilena Letizia, Chatchai Chaotham, Carolin Otto, Klemens Ruprecht, Friedemann Paul, Thanyada Rungrotmongkol, Kittisak Likhitwitayawuid, Chotima Boettcher, Boonchoo Sritularak
Summary: Three new phenanthrene derivatives (1, 2, 4), one new fluorenone (3), and four known compounds (5-8) were isolated from Dendrobium crumenatum Sw. stems using column chromatography, and their chemical structures were determined through spectroscopic analysis. Compound 4's absolute configuration was determined through electronic circular dichroism calculation. The compounds 2 and 4 showed strong immunomodulatory effects on T cells and monocytes.
JOURNAL OF NATURAL PRODUCTS
(2023)
Review
Clinical Neurology
Edgar Carnero Contentti, Darin T. Okuda, Juan I. Rojas, Claudia Chien, Friedemman Paul, Ricardo Alonso
Summary: Differentiating MS from other relapsing inflammatory autoimmune diseases of the central nervous system is crucial in clinical practice. Significant advances have been made in understanding the characteristic clinical symptoms and imaging findings. MRI plays a key role in making the ultimate diagnosis. This review discusses the latest findings in brain, spinal cord, and optic nerve lesions on conventional MRI for distinguishing adult patients with MS from NMOSD and MOGAD.
JOURNAL OF NEUROIMAGING
(2023)
Article
Neurosciences
Lil Meyer-Arndt, Janis Kerkering, Tess Kuehl, Ana Gil Infante, Friedemann Paul, Kamil Sebastian Rosiewicz, Volker Siffrin, Marlen Alisch
Summary: Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system (CNS) and leads to inflammation and neurodegeneration. The exact cause of the neurodegenerative component of MS is unclear. In this study, researchers investigated the effects of inflammatory mediators on human neurons and found that different cytokines have differential effects on neuronal integrity. Combinatorial treatment with certain cytokines induced stronger signaling pathways and highlighted the importance of immune-neuronal crosstalk in understanding the role of inflammatory cytokines in neuronal function and structure.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)
Review
Immunology
Soheil Mohammadi, Mahdi Gouravani, Mohammad Amin Salehi, J. Fernando Arevalo, Steven L. Galetta, Hamid Harandi, Elliot M. Frohman, Teresa C. Frohman, Shiv Saidha, Neda Sattarnezhad, Friedemann Paul
Summary: Recent literature on MS has shown an increasing use of OCT-A to detect changes in the retina and optic nerve. This review analyzes OCT-A studies in MS patients and its potential as a surrogate for CNS tissue changes.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Clinical Neurology
Sven Jarius, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl, Achim Berthele, Katrin Giglhuber, Vivien Haeussler, Joachim Havla, Kerstin W. Hellwig, Martin Huemmert, Ingo Kleiter, Luisa Klotz, Markus Krumbholz, Tania Kuempfel, Friedemann Paul, Marius Ringelstein, Klemens Ruprecht, Makbule Senel, Jan-Patrick Stellmann, Florian Then Bergh, Hayrettin Tumani, Brigitte Wildemann, Corinna Trebst
Summary: The term 'neuromyelitis optica spectrum disorders' (NMOSD) refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) and related clinical syndromes without AQP4-IgG. NMOSD is distinct from multiple sclerosis (MS) in terms of pathogenesis, clinical presentation, treatment, and prognosis. Part 1 of this article series provides updated recommendations on the diagnosis and differential diagnosis of NMOSD, with a focus on distinguishing NMOSD from MS and myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM). Part 2 covers treatment options for NMOSD.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Orhan Aktas, Hans-Peter Hartung, Michael A. Smith, William A. Rees, Kazuo Fujihara, Friedemann Paul, Romain Marignier, Jeffrey L. Bennett, Ho Jin Kim, Brian G. Weinshenker, Sean J. Pittock, Dean M. Wingerchuk, Gary Cutter, Dewei She, Michele Gunsior, Daniel Cimbora, Eliezer Katz, Bruce A. Cree, N-MOmentum Study Investigators
Summary: The study investigates the relationship between biomarkers (sNfL, sUCHL1, sTau, sGFAP) and disease activity/disability in NMOSD, as well as the effects of inebilizumab. Results show that sNfL is the strongest predictor of disability worsening during attacks and follow-up, and inebilizumab treatment is associated with lower levels of sGFAP and sNfL.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Frederike Cosima Oertel, Hanna G. Zimmermann, Seyedamirhosein Motamedi, Claudia Chien, Orhan Aktas, Philipp Albrecht, Marius Ringelstein, Anitha Dcunha, Lekha Pandit, Elena H. Martinez-Lapiscina, Bernardo Sanchez-Dalmau, Pablo Villoslada, Jacqueline Palace, Adriana Roca-Fernandez, Maria Isabel Leite, Srilakshmi M. Sharma, Letizia Leocani, Marco Pisa, Marta Radaelli, Marco Aurelio Lana-Peixoto, Mariana Andrade Fontenelle, Joachim Havla, Fereshteh Ashtari, Rahele Kafieh, Alireza Dehghani, Mohsen Pourazizi, Romain Marignier, Alvaro Cobo-Calvo, Nasrin Asgari, Anu Jacob, Saif Huda, Yang Mao-Draayer, Ari J. Green, Rachel Kenney, Michael R. Yeaman, Terry J. Smith, Lawrence Cook, Alexander U. Brandt, Friedemann Paul, Axel Petzold
Summary: This study evaluated the diagnostic accuracy of intereye differences (IED) in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders (AQP4+NMOSD) and found that IED metrics are valid parameters for the diagnosis of optic neuritis (ON) in AQP4+NMOSD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Susanna Asseyer, Nasrin Asgari, Jeffrey Bennett, Omer Bialer, Yolanda Blanco, Francesca Bosello., Anna Camos-Carreras., Edgar Carnero Contentti., Sara Carta, John Chen, Claudia Chien, Mashina Chomba, Russell C. Dale, Josep Dalmau, Kristina Feldmann, Eoin P. Flanagan, Caroline Froment Tilikete, Carolina Garcia-Alfonso, Joachim Havla, Mark Hellmann, Ho Jin Kim, Philipp Klyscz, Frank Konietschke, Chiara La Morgia, Marco Lana-Peixoto, Maria Isabel Leite, Netta Levin, Michael Levy, Sara Llufriu, Pablo Lopez, Itay Lotan, Alessandra Lugaresi, Romain Marignier, Sara Mariotto, Susan P. Mollan, Cassandra Ocampo, Frederike Cosima Oertel, Maja Olszewska, Jacqueline Palace, Lekha Pandit, Jose Luis Peralta Uribe, Sean Pittock, Sudarshini Ramanathan, Natthapon Rattanathamsakul, Albert Saiz, Sara Samadzadeh, Bernardo Sanchez-Dalmau, Deanna Saylor, Michael Scheel, Tanja Schmitz-Huebsch, Jemal Shifa, Sasitorn Siritho, Pia S. Sperber, Prem S. Subramanian, Alon Tiosano, Adi Vaknin-Dembinsky, Alvaro Jose Mejia Vergara, Adi Wilf-Yarkoni, Luis Alfonso Zarco, Hanna G. Zimmermann, Friedemann Paul, Hadas Stiebel-Kalish
Summary: This is a global study aimed at investigating the effect of early high-dose corticosteroid treatment on optic neuritis. The study will collect various data to evaluate treatment strategies and the accuracy of diagnostic criteria.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Niklas Frahm, Firas Fneish, David Ellenberger, Judith Haas, Micha Loebermann, Melanie Peters, Dieter Poehlau, Anna-Lena Roeper, Sarah Schilling, Alexander Stahmann, Herbert Temmes, Friedemann Paul, Uwe Klaus Zettl
Summary: Despite the protection provided by COVID-19 vaccinations, some individuals with multiple sclerosis (MS) are hesitant to get vaccinated due to concerns about potential side effects and increased disease activity. A study conducted in Germany found that 9.3% of MS patients experienced relapses after receiving the SARS-CoV-2 vaccine, but there was no evidence to suggest that vaccination increased the risk of relapse compared to pre-vaccination levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Ho Jin Kim, Orhan Aktas, Kristina R. Patterson, Schaun Korff, Amy Kunchok, Jeffrey L. Bennett, Brian G. Weinshenker, Friedemann Paul, Hans-Peter Hartung, Daniel Cimbora, Michael A. Smith, Nanette Mittereder, William A. Rees, Dewei She, Bruce A. C. Cree
Summary: The study shows similar clinical outcomes between NMOSD patients with F158 and V158 allele genotypes treated with approved Inebilizumab.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Janis Kerkering, Bakhrom Muinjonov, Kamil S. Rosiewicz, Sebastian Diecke, Charlotte Biese, Juliane Schiweck, Claudia Chien, Dario Zocholl, Thomas Conrad, Friedemann Paul, Marlen Alisch, Volker Siffrin
Summary: Multiple sclerosis (MS) is a common chronic central nervous system inflammatory disease with variable clinical courses. Researchers investigated the mechanisms in benign MS (BMS) compared with progressive MS (PMS) using induced pluripotent stem cells (iPSCs). They found that BMS astrocytes exhibited less axonal damage and upregulated neuronal resilience pathways, accompanied by differential growth factor expression. Furthermore, cocultures of BMS astrocytes and neurons showed neuroprotective effects against inflammatory-induced neurite damage through the expression of specific growth factors and JAK-STAT activation.
JOURNAL OF CLINICAL INVESTIGATION
(2023)