Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy

Neoadjuvant degarelix with or without apalutamide followed by radical prostatectomy for intermediate and high-risk prostate cancer: ARNEO, a randomized, double blind, placebo-controlled trial

(2018) Lorenzo Tosco et al.   BMC CANCER

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Intratumoral and Intertumoral Genomic Heterogeneity of Multifocal Localized Prostate Cancer Impacts Molecular Classifications and Genomic Prognosticators

(2017) Lei Wei et al.   EUROPEAN UROLOGY

The Diagnosis and Treatment of Prostate Cancer

(2017) Mark S. Litwin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo

(2017) Edward J. Hartsough et al.   MOLECULAR CANCER THERAPEUTICS

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT

(2017) Qiuli Liu et al.   Cell Death & Disease

Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model

(2017) Hayley C. Affronti et al.   Oncotarget

Androgen Deprivation Therapy for Advanced Prostate Cancer: Can Evolution Be Accelerated?

(2016) James L. Mohler   Journal of the National Comprehensive Cancer Network

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

(2016) Konstantinos J. Mavrakis et al.   SCIENCE

MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

(2016) Gregory V. Kryukov et al.   SCIENCE

The essential role of methylthioadenosine phosphorylase in prostate cancer

(2016) Gaia Bistulfi et al.   Oncotarget

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

(2016) Katya Marjon et al.   Cell Reports

Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells

(2015) E E Fink et al.   LEUKEMIA

Metastatic phenotype in CWR22 prostate cancer xenograft following castration

(2015) Steven J. Seedhouse et al.   PROSTATE

Expression of spermidine/spermine N1-acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis

(2015) Wei Huang et al.   PROSTATE

Hormone stimulation of androgen receptor mediates dynamic changes in DNA methylation patterns at regulatory elements

(2015) Vineet K. Dhiman et al.   Oncotarget

Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo

(2015) Andrew K. Kwegyir-Afful et al.   Oncotarget

Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth

(2014) Yvette M Carter et al.   CANCER BIOLOGY & THERAPY

Polyamines and cancer: implications for chemotherapy and chemoprevention

(2013) Shannon L. Nowotarski et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Ex vivo culture of human prostate tissue and drug development

(2013) Margaret M. Centenera et al.   Nature Reviews Urology

Dietary Folate Deficiency Blocks Prostate Cancer Progression in the TRAMP Model

(2011) G. Bistulfi et al.   Cancer Prevention Research

Distinct Redox Profiles of Selected Human Prostate Carcinoma Cell Lines: Implications for Rational Design of Redox Therapy

(2011) Luksana Chaiswing et al.   Cancers

Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells

(2010) Gaia Bistulfi et al.   BMC BIOLOGY

Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5′-Methylthioadenosine Phosphorylase

(2010) Indranil Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyamine catabolism and disease

(2009) Robert A. Casero et al.   BIOCHEMICAL JOURNAL

Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools

(2009) G. Bistulfi et al.   FASEB JOURNAL

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Preclinicalversusclinical drug combination studies

(2008) Ting-Chao Chou   LEUKEMIA & LYMPHOMA