Polyamines and cancer: implications for chemotherapy and chemoprevention

Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis

(2012) Patricia A. Welsh et al.   CANCER BIOLOGY & THERAPY

S -adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion

(2012) Chenxu Shi et al.   CARCINOGENESIS

Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1

(2012) Stuart Hazeldine et al.   JOURNAL OF MEDICINAL CHEMISTRY

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of transgenic mice with overexpression of spermidine synthase

(2011) Chenxu Shi et al.   AMINO ACIDS

Recent advances in the molecular biology of metazoan polyamine transport

(2011) R. Poulin et al.   AMINO ACIDS

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes

(2011) Yu Wu et al.   BIOCHEMICAL JOURNAL

Evaluation of Difluoromethylornithine for the Chemoprevention of Barrett's Esophagus and Mucosal Dysplasia

(2011) F. A. Sinicrope et al.   Cancer Prevention Research

Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA

(2011) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

(2011) A. C. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyamine-based small molecule epigenetic modulators

(2011) Shiv K. Sharma et al.   MedChemComm

Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract

(2010) Takeshi Uemura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Targeting Ornithine Decarboxylase for the Prevention of Nonmelanoma Skin Cancer in Humans

(2010) C. A. Elmets et al.   Cancer Prevention Research

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of  -Difluoromethylornithine in Subjects with Previous History of Skin Cancer

(2010) H. H. Bailey et al.   Cancer Prevention Research

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect

(2010) Liqun Huang et al.   CARCINOGENESIS

Phospho-Sulindac (OXT-328), a Novel Sulindac Derivative, Is Safe and Effective in Colon Cancer Prevention in Mice

(2010) Gerardo G. Mackenzie et al.   GASTROENTEROLOGY

Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity

(2010) Shih-Kuang S. Hong et al.   INFLAMMATORY BOWEL DISEASES

Cytoplasmic Accumulation of the RNA-binding Protein HuR Stabilizes the Ornithine Decarboxylase Transcript in a Murine Nonmelanoma Skin Cancer Model

(2010) Shannon L. Nowotarski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

(Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic Modulators

(2010) Shiv K. Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis

(2009) R. H. Barker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polyamine catabolism and disease

(2009) Robert A. Casero et al.   BIOCHEMICAL JOURNAL

The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer

(2009) K. Dredge et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines

(2009) Allison Pledgie-Tracy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes

(2009) Y. Huang et al.   CLINICAL CANCER RESEARCH

Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor

(2009) Chaim Kahana   Essays in Biochemistry

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Recent Advances in the Development of Polyamine Analogues as Antitumor Agents§

(2009) Robert A. Casero et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells

(2008) Amy Hacker et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial

(2008) A. R. Simoneau et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

(2008) Frank L. Meyskens et al.   Cancer Prevention Research

The Novel Polyamine Analogue CGC-11093 Enhances the Antimyeloma Activity of Bortezomib

(2008) J. S. Carew et al.   CANCER RESEARCH

Polyaminohydroxamic Acids and Polyaminobenzamides as Isoform Selective Histone Deacetylase Inhibitors§

(2008) Sheeba Varghese et al.   JOURNAL OF MEDICINAL CHEMISTRY

ActivatedK-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis

(2008) Upal K. Basu Roy et al.   MOLECULAR CARCINOGENESIS

Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues

(2008) Andrew C. Goodwin et al.   PROSTATE