Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT
Authors
Keywords
-
Journal
Cell Death & Disease
Volume 8, Issue 8, Pages e3007
Publisher
Springer Nature
Online
2017-08-24
DOI
10.1038/cddis.2017.417
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer
- (2016) Jonathan Welti et al. EUROPEAN UROLOGY
- Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis
- (2016) Qiuli Liu et al. Oncotarget
- Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer
- (2016) Kathryn E. Ware et al. Oncotarget
- The HIF/PHF8/AR axis promotes prostate cancer progression
- (2016) D Tong et al. Oncogenesis
- Anti-Cancer Stem-like Cell Compounds in Clinical Development – An Overview and Critical Appraisal
- (2016) Fabrizio Marcucci et al. Frontiers in Oncology
- Metformin is a novel suppressor for transforming growth factor (TGF)-β1
- (2016) Han Xiao et al. Scientific Reports
- Evaluation of Effects of Metformin in Primary Ovarian Cancer Cells
- (2015) Seema Patel et al. Asian Pacific Journal of Cancer Prevention
- Cancer statistics, 2015
- (2015) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Multinucleation and Mesenchymal-to-Epithelial Transition Alleviate Resistance to Combined Cabazitaxel and Antiandrogen Therapy in Advanced Prostate Cancer
- (2015) S. K. Martin et al. CANCER RESEARCH
- Understanding the Mechanisms of Androgen Deprivation Resistance in Prostate Cancer at the Molecular Level
- (2015) Theodoros Karantanos et al. EUROPEAN UROLOGY
- Metformin represses androgen-dependent and androgen-independent prostate cancers by targeting androgen receptor
- (2015) Yan Wang et al. PROSTATE
- LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells
- (2015) Nian-Shuang Li et al. TUMOR BIOLOGY
- The effect of metformin on cancer-specific survival outcomes in diabetic patients undergoing radical cystectomy for urothelial carcinoma of the bladder
- (2015) Madhur Nayan et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- TNF signaling mediates an enzalutamide-induced metastatic phenotype of prostate cancer and microenvironment cell co-cultures
- (2015) Kai Sha et al. Oncotarget
- The role of epithelial plasticity in prostate cancer dissemination and treatment resistance
- (2014) Rhonda L. Bitting et al. CANCER AND METASTASIS REVIEWS
- Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer
- (2014) C. Liu et al. CLINICAL CANCER RESEARCH
- Metformin in Chemotherapy-naive Castration-resistant Prostate Cancer: A Multicenter Phase 2 Trial (SAKK 08/09)
- (2014) Christian Rothermundt et al. EUROPEAN UROLOGY
- JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells
- (2014) RENG-YUN LIU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer
- (2014) Emmanuel S. Antonarakis et al. NEW ENGLAND JOURNAL OF MEDICINE
- Enzalutamide in Metastatic Prostate Cancer before Chemotherapy
- (2014) Tomasz M. Beer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model
- (2014) H G Nguyen et al. ONCOGENE
- STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion
- (2013) Kyung Hwa Cho et al. CANCER LETTERS
- Antitumour activity of enzalutamide (MDV3100) in patients with metastatic castration-resistant prostate cancer (CRPC) pre-treated with docetaxel and abiraterone
- (2013) D. Bianchini et al. EUROPEAN JOURNAL OF CANCER
- Epithelial to Mesenchymal Transition Promotes Breast Cancer Progression via a Fibronectin-dependent STAT3 Signaling Pathway
- (2013) Nikolas Balanis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential Androgen Deprivation Therapies with Anti-androgens Casodex/Bicalutamide or MDV3100/EnzalutamideversusAnti-androgen Receptor ASC-J9® Lead to PromotionversusSuppression of Prostate Cancer Metastasis
- (2013) Tzu-Hua Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells
- (2013) Chengfei Liu et al. PROSTATE
- Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling
- (2013) T-H Lin et al. Cell Death & Disease
- Androgen Receptor on the Move: Boarding the Microtubule Expressway to the Nucleus
- (2012) M. Thadani-Mulero et al. CANCER RESEARCH
- Androgen Receptor Directed Therapies in Castration-Resistant Metastatic Prostate Cancer
- (2012) Won Kim et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
- (2012) Zheng Sun et al. NATURE MEDICINE
- Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy
- (2012) Charles J. Ryan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Androgen Deprivation Causes Epithelial-Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy
- (2011) Y. Sun et al. CANCER RESEARCH
- Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
- (2011) T Tomic et al. Cell Death & Disease
- Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells
- (2010) Gaoliang Ouyang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
- Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
- (2009) C. Tran et al. SCIENCE
- Inhibition of STAT3Tyr705 Phosphorylation by Smad4 Suppresses Transforming Growth Factor -Mediated Invasion and Metastasis in Pancreatic Cancer Cells
- (2008) S. Zhao et al. CANCER RESEARCH
- Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells
- (2008) Valerie A Odero-Marah et al. CELL RESEARCH
- Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
- (2008) Jing Yang et al. DEVELOPMENTAL CELL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now