Review
Biochemistry & Molecular Biology
Julie Bas, Trang Nguyen, Germain Gillet
Summary: Bcl-2 family proteins, known for their role in regulating apoptosis, also have non-canonical functions in the CNS. Bcl-xL, a close homolog of Bcl-2, plays a crucial role in neuronal development, promoting ATP generation in mitochondria and contributing to synaptic transmission without causing cell death. Understanding the roles of cell death machinery in neurons may have important clinical implications for degenerative diseases and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chao-Yu Hsu, Wei-Ting Yang, Ju-Hwa Lin, Chien-Hsing Lu, Kai-Cheng Hu, Tsuo-Hung Lan, Chia-Che Chang
Summary: Sertindole has been found to have antiproliferative effects on bladder cancer cells by inhibiting the STAT3/BCL-xL signaling pathway, suggesting its potential as a therapeutic strategy for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Hui San Chin, Nai Yang Fu
Summary: The protein Mcl-1 plays a crucial role in cell survival, with its essential functions revealed through genetically engineered mouse models. Understanding its physiological roles in different tissues and developmental stages has implications for the treatment of various diseases, including cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Marie-Claire Fitzgerald, Philip J. O'Halloran, Sean A. Kerrane, Triona Ni Chonghaile, Niamh M. C. Connolly, Brona M. Murphy
Summary: Systems-level analysis of apoptosis protein expression and signaling interactions can differentiate between medulloblastoma cell lines with different responses to chemotherapy. BCL-XL and MCL-1 were identified as key anti-apoptotic proteins in medulloblastoma, with distinct protective roles. We provide rationale for further evaluation of BCL-XL and MCL-1 inhibitors in medulloblastoma treatment.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Anna Maria Luciano, Ana B. Perez-Oliva, Victoriano Mulero, Donatella Del Bufalo
Summary: Apoptosis is crucial for eliminating damaged cells in multicellular organisms. Bcl-xL, an anti-apoptotic protein, plays significant roles in cancer, including melanoma, by regulating cell survival, migration, invasion, and angiogenesis. Targeting Bcl-xL may offer potential benefits for cancer patients, but further studies are needed to develop safe and effective inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Opydo, Anna Mlyczynska, Ewa Mlyczynska, Agnieszka Rak, Elzbieta Kolaczkowska
Summary: Acute myeloid leukemia (AML) is a blood cancer characterized by abnormal cell proliferation and inhibition of apoptosis. The MCL-1 protein plays a critical role in the survival of AML cells. This study investigated the effects of a specific MCL-1 inhibitor, S63845, alone and in combination with other inhibitors, on AML cell lines. The results showed that S63845 decreased cell viability and induced apoptosis, and combined treatment enhanced apoptosis and induced cell differentiation. These findings suggest the potential use of MCL-1 inhibitors in combination with other pro-survival protein inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Akira Ohtsu, Seiji Arai, Tatsuhiro Sawada, Mai Kato, Yuta Maeno, Yoshiyuki Miyazawa, Yuji Fujizuka, Yoshitaka Sekine, Hidekazu Koike, Hiroshi Matsui, Kazuhiro Suzuki
Summary: Metastatic urothelial cancer is a lethal disease, and novel therapeutic strategies are needed for patients who do not benefit from current treatments. This study found that targeting anti-apoptotic proteins can induce apoptosis in urothelial cancer cells and may be a promising treatment strategy for FGFR wild-type metastatic urothelial cancer patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Virology
Yiqun Li, Yuding Fan, Yong Zhou, Nan Jiang, Mingyang Xue, Yan Meng, Wenzhi Liu, Jingjing Zhang, Ge Lin, Lingbing Zeng
Summary: The study showed that AdBcl-xL protein level was significantly reduced during GSIV infection, and it played a negative role by binding to AdBak and inhibiting p53 activation, thus preventing GSIV-induced mitochondrial apoptosis and virus replication.
Article
Gastroenterology & Hepatology
Paula Hoffmeister-Wittmann, Andreas Mock, Federico Nichetti, Felix Korell, Christop E. Heilig, Anna-Lena Scherr, Michael Gunther, Thomas Albrecht, Eblina Kelmendi, Kaiyu Xu, Luisa Nader, Annika Kessler, Nathalie Schmitt, Sarah Fritzsche, Sofia Weiler, Benjamin Sobol, Albrecht Stenzinger, Stefan Boeck, Christoph B. Westphalen, Klaus Schulze-Osthoff, Jorg Trojan, Thomas Kindler, Wilko Weichert, Karsten Spiekermann, Michael Bitzer, Gunnar Folprecht, Anna-Lena Illert, Melanie Boerries, Frederick Klauschen, Sebastian Ochsenreiter, Jens Siveke, Sebastian Bauer, Hanno Glimm, Benedikt Brors, Jennifer Huellein, Daniel Huebschmann, Sebastian Uhrig, Peter Horak, Simon Kreutzfeld, Jesus M. Banales, Christoph Springfeld, Dirk Jaeger, Peter Schirmacher, Stephanie Roessler, Steffen Ormanns, Benjamin Goeppert, Stefan Froehling, Bruno C. Koehler
Summary: The study identified Bcl-x(L) as a key protein in cell death resistance of CCA and suggested its potential prognostic value, serving as a potential therapeutic target.
LIVER INTERNATIONAL
(2022)
Article
Virology
Pin-Han Chen, Tsai-Ching Hsueh, Jen-Leih Wu, Jiann-Ruey Hong
Summary: This study demonstrates that infectious spleen and kidney necrosis virus (ISKNV) infection can induce host cell death through the regulation of mitochondrial membrane potential. The dynamic interaction between pro-apoptotic and anti-apoptotic members of the Bcl-2 family plays a crucial role in this process.
Review
Biochemistry & Molecular Biology
Cristina Mas-Bargues, Consuelo Borras, Jose Vina
Summary: Cellular senescence is related to the inability of cells to adapt to stress conditions, a specific level of senescence can promote development, remodeling and healing, while chronicity of senescence can result from constant stresses and a weakening immune system. Centenarians overexpress Bcl-xL, which helps them avoid the deleterious effects of accumulated senescent cells and maintain a fully functional immune system. There is a paradox in the fact that Bcl-xL inhibitors have been shown to protect from aging in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Danxia Huang, Ying Wang, Baichun Hu, Zhaohu Luo, Junhao Huang, Jian Wang, Fengjiao Zhang
Summary: The selective binding mechanism between Mcl-1 and Bcl-XL depends on key residues, particularly Phe270 in Mcl-1 and Tyr195 in Bcl-XL. These findings are of significant importance for the discovery of safer anticancer drug candidates.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Cell Biology
Fan Luo, Fei-Teng Lu, Miao-Zhen Qiu, Ting Zhou, Wen-Juan Ma, Min Luo, Kang-Mei Zeng, Qiu-Yun Luo, Wen-Tao Pan, Lin Zhang, Zeng-Fei Xia, Zhong-Han Zhang, Jia-Xin Cao, Hong-Yun Zhao, Li Zhang, Da-Jun Yang
Summary: The combination of APG-1252 and gemcitabine exhibits synergistic anticancer activities against nasopharyngeal carcinoma (NPC), providing a promising treatment modality for patients. This combination enhanced NPC cell apoptosis and inhibited invasion, migration, and proliferation both in vitro and in vivo through various mechanisms including caspase-dependent pathways and blocking signaling pathways. Results suggest a potential new therapeutic strategy for advanced NPC.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Haolan Wang, Ming Guo, Hudie Wei, Yongheng Chen
Summary: MCL-1, an antiapoptotic protein, is frequently overexpressed in many tumor types and closely associated with tumorigenesis, poor prognosis, and drug resistance. Its central role in regulating the mitochondrial apoptotic pathway makes it an attractive target for cancer therapy. Progress has been made towards MCL-1 inhibitors and some have entered clinical trials.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Cell Biology
Flore Sneyers, Martijn Kerkhofs, Femke Speelman-Rooms, Kirsten Welkenhuyzen, Rita La Rovere, Ahmed Shemy, Arnout Voet, Guy Eelen, Mieke Dewerchin, Stephen W. G. Tait, Bart Ghesquiere, Martin D. Bootman, Geert Bultynck
Summary: Intracellular Ca2+ signals play a crucial role in various cellular processes. Research has shown that BAPTAi can induce apoptosis in cancer cells by inhibiting mTORC1 activity and impairing glycolysis, independent of Ca2+ signaling. Additionally, direct inhibition of PFKFB3 emerges as a potential therapeutic target in MCL-1-dependent cancers.
CELL DEATH & DISEASE
(2023)
Article
Gastroenterology & Hepatology
Di Zhang, Yu Zhang, Xiwu Zhang, Hongjun Zhai, Xiaoli Sun, Yiming Li
Summary: This study revealed that circ_0091579 promotes the progression of HCC by regulating the miR-1225-5p/PLCB1 axis, providing a novel molecular basis for HCC development.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Correction
Biochemistry & Molecular Biology
Junfeng Zhang, Hongwei Tian, Can Li, Lin Cheng, Shuang Zhang, Xiaomei Zhang, Ruibo Wang, Fen Xu, Lei Dai, Gang Shi, Xiaolei Chen, Yiming Li, Tao Du, Jie Deng, Yu Liu, Yang Yang, Yuquan Wei, Hongxin Deng
MOLECULAR IMMUNOLOGY
(2022)
Retraction
Oncology
Shuo Chen, Xi Chen, Wei Li, Tao Shan, Wan Run Lin, Jiancang Ma, Xijuan Cui, Wenbin Yang, Gang Cao, Yiming Li, Li Wang, Ya'an Kang
Article
Public, Environmental & Occupational Health
Yuheng Jia, Gaden Luosang, Yiming Li, Jianyong Wang, Pengyu Li, Tianyuan Xiong, Yijian Li, Yanbiao Liao, Zhengang Zhao, Yong Peng, Yuan Feng, Weili Jiang, Wenjian Li, Xinpei Zhang, Zhang Yi, Mao Chen
Summary: In this study, a risk prediction model based on deep learning was developed to predict major or life-threatening bleeding complications after transcatheter aortic valve replacement (TAVR). The model outperformed traditional models in terms of discrimination and calibration, and showed great performance in stratifying high-and low-bleeding risk patients.
CLINICAL EPIDEMIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Guang-zhi Liao, Yi-ming Li, Lin Bai, Yu-yang Ye, Yong Peng
Summary: Revascularization is more effective in reducing mortality than medical treatment alone in patients with CKD and CAD. This benefit is consistent in patients with stable CAD and elderly patients. However, future randomized controlled trials are required to confirm these findings.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Hongtao Ren, Yali Wang, Ya Guo, Mincong Wang, Xiulong Ma, Wen Li, Yuyan Guo, Yiming Li
Summary: Matrine inhibits the proliferation and invasion of colorectal cancer cells by reducing the activity of the p38 signaling pathway. This study discovered that Erlin1 is a novel target of matrine and modulates the growth and migration of CRC cells. Matrine treatment can reverse the oncogenic function of Erlin1 and may be an effective therapeutic strategy for CRC patients.
Article
Gastroenterology & Hepatology
Yang Liu, Xin Zhang, Shuo Chen, Jiazhong Wang, Shuo Yu, Yiming Li, Meng Xu, Harouna Aboubacar, Junhui Li, Tao Shan, Jixin Wang, Gang Cao
Summary: Chronic alcohol use stimulates the formation of NETs through LPS activation of TLR4, leading to increased alcoholic hepatosteatosis and HCC.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yafei Zhang, Hongwei Lu, Hong Ji, Yiming Li
Summary: This study investigated the role of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and p53 in mucosal apoptosis in portal hypertensive gastropathy (PHG). The results showed that HIF-1 alpha and p53 were significantly upregulated in the gastric mucosa of PHG patients and animal models, and inhibition of these molecules could attenuate apoptosis. It was also found that HIF-1 alpha regulated the p53-induced mucosal epithelial apoptotic signaling pathway. Therefore, HIF-1 alpha and p53 may be potential therapeutic targets for PHG.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Jing-Jing He, Tian-Yuan Xiong, Yi-Jun Yao, Yong Peng, Jia-Fu Wei, Sen He, Yong Chen, Qiao Li, Zhen-Gang Zhao, Xin Wei, Wen-Xia Zhou, Yu-Jia Liang, Hong Tang, Guo Chen, Xuan Zhou, Ming-Xia Zheng, Wei Meng, Yan-Biao Liao, Yi-Jian Li, Yi-Ming Li, Fei Chen, Yuan-Weixiang Ou, Qi Liu, Xi Li, Xi Wang, Yi Zhang, Zhong-Kai Zhu, Hao-Ran Yang, Kai-Yu Jia, Mao Chen, Yuan Feng
Summary: This study investigated the impact of sex on outcomes following transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valves (BAVs). The results showed that women with BAVs had fewer comorbidities, while men had a higher proportion of type 1 BAV, more calcification, and larger aortic roots. Men had better in-hospital outcomes, except for the need for second valve implantation, but 1-year survival was comparable between sexes.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Yiming Li, Yan Lu, Xinmin Tan, Zilong Zhang, Feng Feng, Ruhong Li
Summary: This study investigated the effect of endotracheal tube (ETT) size on airway resistance (RAW) and dynamic lung compliance (COMPL) in patients undergoing laparoscopic colorectal surgery. The results showed that in the non-pneumoperitoneal state, a smaller ETT internal diameter resulted in higher RAW and lower COMPL. In the pneumoperitoneal state, the ETT size had no effect on COMPL, but the RAW was higher with an ID7.0 ETT compared to an ID8.0 ETT within a certain range.
Article
Chemistry, Multidisciplinary
Yu Wang, Qiong Xia, Xiao Hua, Yanyan Guo, Jing Shi, Yi-Ming Li
Summary: Activity-based ubiquitin probes (Ub-ABPs) are effective tools for studying the molecular mechanism and profiling of deubiquitinating enzymes (DUBs). However, the synthesis of commonly used biotin-bearing Ub-ABPs is technically challenging. In this study, a one-pot semi-synthetic strategy was developed to obtain Ub-ABPs carrying a biotin tag through enzymatic ligation, N-S acyl transfer, and aminolysis reaction without purification steps. These probes enable the capture of different DUBs families for enrichment and immunoblotting using the attached biotin tag.
CHINESE CHEMICAL LETTERS
(2023)
Review
Gastroenterology & Hepatology
Shu-Wu Zhao, Yi-Ming Li, Yi-Lin Li, Chen Su
Summary: The COVID-19 pandemic has been a global health threat for nearly 3 years and it often causes liver injury in addition to pulmonary complications. The incidence of liver injury is significantly increased in severe cases and understanding its causes is urgently needed. Clinical features of liver injury include abnormal liver function and imaging changes, which can be evaluated through tests and scans. Risk factors for liver injury in COVID-19 patients include male sex, preexisting liver disease, diabetes, obesity, and hypertension. The mechanism of liver injury caused by COVID-19 is not fully understood, but it is believed to be related to inflammatory response, hypoxic damage, ischemia-reperfusion injury, and drug side effects. This review summarizesthe existing literature on liver injury caused by COVID-19, including clinical features, underlying mechanisms, and potential risk factors. Clinical management and recommendations for patients with liver injury are also discussed.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Pharmacology & Pharmacy
Guangzhi Liao, Xiangpeng Wang, Yiming Li, Xuefeng Chen, Ke Huang, Lin Bai, Yuyang Ye, Yong Peng
Summary: This study summarized the benefits and safety of antidyslipidemia pharmacotherapy in patients with chronic kidney disease. Statin-based therapies were found to significantly and safely reduce all-cause mortality and major composite cardiovascular events in non-dialysis CKD patients, especially in those with established coronary artery disease.
Article
Chemistry, Organic
Jia-Hui Tang, Ru-Jing Yuan, Jie Luo, Ning Wang, Jun Wang, Yi-Ming Li
Summary: We have developed a new strategy, called serine/threonine ligation (STL)-assisted diaminodiacid (DADA), for the flexible construction of disulfide surrogates. This strategy allows for the incorporation of more abundant -Aa-Ser/Thr-ligation sites, and has been successfully applied to synthesize intrachain and interchain disulfide surrogates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiming Li, Yu Wu, Jingjing He, Weili Jiang, Jianyong Wang, Yong Peng, Yuheng Jia, Tianyuan Xiong, Kaiyu Jia, Zhang Yi, Mao Chen
Summary: In this study, a deep learning algorithm was used to achieve rapid classification and diagnosis of coronary artery disease from CCTA images. The deep learning model can automatically segment the coronary artery quickly and accurately, delivering a diagnosis of >= 50% coronary artery stenosis. Artificial intelligence methods such as deep learning have the potential to significantly improve efficiency in CCTA image analysis.
EUROPEAN RADIOLOGY
(2022)
