Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance

Stem cells from human exfoliated deciduous teeth correct the immune imbalance of allergic rhinitis via Treg cells in vivo and in vitro

(2019) Yu-Yang Dai et al.   Stem Cell Research & Therapy

Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines

(2019) Guido Moll et al.   TRENDS IN MOLECULAR MEDICINE

Manufacturing of primed mesenchymal stromal cells for therapy

(2019) James Q. Yin et al.   Nature Biomedical Engineering

Challenges and Controversies in Human Mesenchymal Stem Cell Therapy

(2019) Barbara Lukomska et al.   Stem Cells International

Mesenchymal Stem Cells Derived and Cultured from Glioblastoma Multiforme Increase Tregs, Downregulate Th17, and Induce the Tolerogenic Phenotype of Monocyte-Derived Cells

(2019) Kalina Tumangelova-Yuzeir et al.   Stem Cells International

Biological functions of mesenchymal stem cells and clinical implications

(2019) Abderrahim Naji et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mesenchymal Stromal Cell Therapeutic Delivery: Translational Challenges to Clinical Application

(2019) Henry Caplan et al.   Frontiers in Immunology

The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy

(2019) Daniel J. Weiss et al.   Frontiers in Immunology

Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs

(2019) Andreas Robert Rudolf Weiss et al.   Frontiers in Immunology

Extracellular vesicles from mesenchymal stem cells prevent contact hypersensitivity through the suppression of Tc1 and Th1 cells and expansion of regulatory T cells

(2019) Liyan Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mesenchymal stromal cell-derived extracellular vesicles: regenerative and immunomodulatory effects and potential applications in sepsis

(2018) Guoping Zheng et al.   CELL AND TISSUE RESEARCH

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

(2018) Jacques Galipeau et al.   Cell Stem Cell

Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway

(2018) Bin Zhang et al.   CYTOTHERAPY

IL-17A improves the efficacy of mesenchymal stem cells in ischemic-reperfusion renal injury by increasing Treg percentages by the COX-2/PGE2 pathway

(2018) Ming Bai et al.   KIDNEY INTERNATIONAL

Microenvironmental cues enhance mesenchymal stem cell-mediated immunomodulation and regulatory T-cell expansion

(2018) Rohini L. Kadle et al.   PLoS One

Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis

(2018) Yoojun Nam et al.   PLoS One

Mesenchymal-myeloid interaction in the regulation of immunity

(2018) Tik Shing Cheung et al.   SEMINARS IN IMMUNOLOGY

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22

(2018) Kati Hyvärinen et al.   Frontiers in Immunology

Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo

(2018) Clémence Roux et al.   Frontiers in Immunology

Long-Term Clinical and Immunological Profile of Kidney Transplant Patients Given Mesenchymal Stromal Cell Immunotherapy

(2018) Norberto Perico et al.   Frontiers in Immunology

Immunomonitoring of MSC-Treated GvHD Patients Reveals Only Moderate Potential for Response Prediction but Indicates Treatment Safety

(2018) Joni Keto et al.   Molecular Therapy-Methods & Clinical Development

Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran

(2018) Mohsen Ghoryani et al.   BIOMEDICINE & PHARMACOTHERAPY

Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice

(2018) Ju-Hyun AN et al.   BMC Veterinary Research

Infusion of third-party mesenchymal stromal cells after kidney transplantation: a phase I-II, open-label, clinical study

(2018) Pauline Erpicum et al.   KIDNEY INTERNATIONAL

Regulatory T cells in the treatment of disease

(2018) Amir Sharabi et al.   NATURE REVIEWS DRUG DISCOVERY

Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation

(2018) Paul Lohan et al.   Frontiers in Immunology

Mesenchymal stem cells upregulate Treg cells via sHLA-G in SLE patients

(2017) Chen Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Infusion of mesenchymal stromal cells after deceased liver transplantation: A phase I–II, open-label, clinical study

(2017) Olivier Detry et al.   JOURNAL OF HEPATOLOGY

Immune Tolerance of Human Dental Pulp-Derived Mesenchymal Stem Cells Mediated by CD4+CD25+ FoxP3+ Regulatory T-Cells and Induced by TGF-β1 and IL-10

(2017) Jong Won Hong et al.   YONSEI MEDICAL JOURNAL

A Pilot Study of Mesenchymal Stem Cell Therapy for Acute Liver Allograft Rejection

(2017) Ming Shi et al.   Stem Cells Translational Medicine

ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells

(2017) Hyun-Joo Lee et al.   Scientific Reports

Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions

(2016) Jian Gu et al.   Cellular & Molecular Immunology

Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord–Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation

(2016) Lei Gao et al.   JOURNAL OF CLINICAL ONCOLOGY

TLR3 or TLR4 Activation Enhances Mesenchymal Stromal Cell-Mediated Treg Induction via Notch Signaling

(2016) Iran Rashedi et al.   STEM CELLS

Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses

(2016) Laura Chiossone et al.   STEM CELLS

Umbilical cord-derived mesenchymal stem cells reversed the suppressive deficiency of T regulatory cells from peripheral blood of patients with multiple sclerosis in a co-culture – a preliminary study

(2016) Hongna Yang et al.   Oncotarget

Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptosis and Cell Cycle Arrest by Expression of Indoleamine 2, 3-Dioxygenase

(2016) Xiuying Li et al.   Stem Cells International

Immunomodulation Effects of Mesenchymal Stromal Cells on Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation

(2015) Ke Zhao et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus

(2015) Dandan Wang et al.   Cellular & Molecular Immunology

Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients

(2015) Enrica Favaro et al.   DIABETOLOGIA

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

(2015) Gavin M. Mason et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Indoleamine 2, 3-Dioxgenase Transfected Mesenchymal Stem Cells Induce Kidney Allograft Tolerance by Increasing the Production and Function of Regulatory T Cells

(2015) Yue He et al.   TRANSPLANTATION

Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells

(2015) Emer F Cahill et al.   Stem Cell Research & Therapy

First-in-Human Case Study: Multipotent Adult Progenitor Cells for Immunomodulation After Liver Transplantation

(2015) Yorick Soeder et al.   Stem Cells Translational Medicine

Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of Treg/Th17 cells

(2014) Lanman Xu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8

(2014) Justin P. Edwards et al.   JOURNAL OF IMMUNOLOGY

Delta-like 1–Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

(2014) Catarina Mota et al.   JOURNAL OF IMMUNOLOGY

Interaction between Adipose Tissue-Derived Mesenchymal Stem Cells and Regulatory T-Cells

(2013) Anja U. Engela et al.   CELL TRANSPLANTATION

Efficacy and safety of mesenchymal stromal cell treatment from related donors for patients with refractory aplastic anemia

(2013) Yang Xiao et al.   CYTOTHERAPY

Prostaglandin E2 Potentiates Mesenchymal Stem Cell-Induced IL-10+IFN- +CD4+ Regulatory T Cells To Control Transplant Arteriosclerosis

(2013) W.-T. Hsu et al.   JOURNAL OF IMMUNOLOGY

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

(2013) Sara M. Melief et al.   STEM CELLS

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

(2013) Bin Zhang et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus

(2012) X Li et al.   BONE MARROW TRANSPLANTATION

Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction

(2012) Beatrice Del Papa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?

(2012) Stephen P Burr et al.   IMMUNOLOGY AND CELL BIOLOGY

Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IL-10-Dependent Regulatory Dendritic Cells by SOCS3 Activation

(2012) X. Liu et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Stromal Cells Treatment Attenuates Dry Eye in Patients With Chronic Graft-versus-host Disease

(2012) Jianyu Weng et al.   MOLECULAR THERAPY

Donor-Derived Mesenchymal Stem Cells Combined With Low-Dose Tacrolimus Prevent Acute Rejection After Renal Transplantation

(2012) Yanwen Peng et al.   TRANSPLANTATION

On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation

(2012) Anja U. Engela et al.   Frontiers in Immunology

The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells

(2011) D. Mougiakakos et al.   BLOOD

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

(2011) R. Ciccocioppo et al.   GUT

Immunomodulatory Function of Regulatory Dendritic Cells Induced by Mesenchymal Stem Cells

(2011) Zhi-Gang Zhao et al.   IMMUNOLOGICAL INVESTIGATIONS

Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study

(2010) J. Liang et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

Autologous Mesenchymal Stromal Cells and Kidney Transplantation: A Pilot Study of Safety and Clinical Feasibility

(2010) N. Perico et al.   Clinical Journal of the American Society of Nephrology

Cell contact, prostaglandin E2and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+regulatory T cells

(2009) K. English et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population

(2008) B. Zhang et al.   BLOOD

Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppression

(2008) Aisha Nasef et al.   CELLULAR IMMUNOLOGY

Mesenchymal cells recruit and regulate T regulatory cells

(2008) M DIIANNI   EXPERIMENTAL HEMATOLOGY

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+Regulatory T Cells

(2007) Zohair Selmani et al.   STEM CELLS