Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma

Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts

(2019) Yuanhang Liu et al.   Scientific Reports

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

(2019) Carlos J Diaz Osterman et al.   eLife

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

(2018) Mathieu Unbekandt et al.   CANCER RESEARCH

Rucaparib: An emerging parp inhibitor for treatment of recurrent ovarian cancer

(2018) Angela Musella et al.   CANCER TREATMENT REVIEWS

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

(2018) Stephen J. Pettitt et al.   Nature Communications

Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

(2018) Philipp M. Cromm et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer

(2017) Tessa Humphries-Bickley et al.   MOLECULAR CANCER THERAPEUTICS

High grade serous ovarian carcinomas originate in the fallopian tube

(2017) S. Intidhar Labidi-Galy et al.   Nature Communications

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

(2016) Hui Zhang et al.   CELL

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status

(2016) F. Coscia et al.   Nature Communications

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

(2016) James Campbell et al.   Cell Reports

Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer

(2016) Alison M. Kurimchak et al.   Cell Reports

Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules

(2015) Yu Yu et al.   CANCER CELL

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

(2015) Vijay Pralhad Kale et al.   CANCER LETTERS

Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells

(2015) T Y Prudnikova et al.   ONCOGENE

Upregulated CDK16 Expression in Serous Epithelial Ovarian Cancer Cells

(2015) Qi Zhou et al.   MEDICAL SCIENCE MONITOR

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

(2014) Vijay Pralhad Kale et al.   CANCER LETTERS

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

(2014) Mathieu Unbekandt et al.   Cell Communication and Signaling

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer

(2014) Mathieu Unbekandt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Evaluating Strategies to Normalise Biological Replicates of Western Blot Data

(2014) Andrea Degasperi et al.   PLoS One

The dynamic nature of the kinome

(2013) Lee M. Graves et al.   BIOCHEMICAL JOURNAL

Characterization of the Novel Broad-Spectrum Kinase Inhibitor CTx-0294885 As an Affinity Reagent for Mass Spectrometry-Based Kinome Profiling

(2013) Luxi Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Getting to Know Ovarian Cancer Ascites: Opportunities for Targeted Therapy-Based Translational Research

(2013) Nuzhat Ahmed et al.   Frontiers in Oncology

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

(2012) James S. Duncan et al.   CELL

A Phase I Trial of Dasatinib, an Src-Family Kinase Inhibitor, in Combination with Paclitaxel and Carboplatin in Patients with Advanced or Recurrent Ovarian Cancer

(2012) A. A. Secord et al.   CLINICAL CANCER RESEARCH

EGFR/HER-targeted therapeutics in ovarian cancer

(2012) Jason A Wilken et al.   Future Medicinal Chemistry

Super-SILAC Allows Classification of Diffuse Large B-cell Lymphoma Subtypes by Their Protein Expression Profiles

(2012) Sally J. Deeb et al.   MOLECULAR & CELLULAR PROTEOMICS

Primary culture and immortalization of human fallopian tube secretory epithelial cells

(2012) Alison M Karst et al.   Nature Protocols

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

(2011) Matthew P. Patricelli et al.   CHEMISTRY & BIOLOGY

c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G

(2011) Khadija Rafiq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Super-SILAC for tumors and tissues

(2010) Thomas A Neubert et al.   NATURE METHODS

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

(2010) B. W. Murray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale Proteomics Analysis of the Human Kinome

(2009) Felix S. Oppermann et al.   MOLECULAR & CELLULAR PROTEOMICS