A novel small-molecule MRCK inhibitor blocks cancer cell invasion

PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction

(2014) Paolo Armando Gagliardi et al.   JOURNAL OF CELL BIOLOGY

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer

(2014) Mathieu Unbekandt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

(2013) Koji Ando et al.   JOURNAL OF CELL BIOLOGY

The benzophenanthridine alkaloid chelerythrine binds to DNA by intercalation: Photophysical aspects and thermodynamic results of iminium versus alkanolamine interaction

(2013) Pritha Basu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Kinome Render: a stand-alone and web-accessible tool to annotate the human protein kinome tree

(2013) Matthieu Chartier et al.   PeerJ

ROCKII Ser1366phosphorylation reflects the activation status

(2012) Hsiang-Hao Chuang et al.   BIOCHEMICAL JOURNAL

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine

(2012) Gerda Brunhofer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression

(2012) Bo Rafn et al.   MOLECULAR CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration

(2011) Lin Huo et al.   EMBO JOURNAL

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase

(2011) Ivan Tan et al.   FEBS LETTERS

Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion

(2011) Timo Heikkila et al.   PLoS One

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices

(2009) Kevin E. Fisher et al.   JOURNAL OF CELL SCIENCE

Non-muscle myosin II takes centre stage in cell adhesion and migration

(2009) Miguel Vicente-Manzanares et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Tripartite Complex Containing MRCK Modulates Lamellar Actomyosin Retrograde Flow

(2008) Ivan Tan et al.   CELL

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

(2008) Sung Hee Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY