Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells

Group I Paks as therapeutic targets in NF2-deficient meningioma

(2015) Hoi-Yee Chow et al.   Oncotarget

Molecular Pathways: Targeting the Kinase Effectors of RHO-Family GTPases

(2014) T. Y. Prudnikova et al.   CLINICAL CANCER RESEARCH

Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas

(2014) Jianyuan Wu et al.   MEDICAL ONCOLOGY

Pak1 Kinase Links ErbB2 to  -Catenin in Transformation of Breast Epithelial Cells

(2013) L. E. Arias-Romero et al.   CANCER RESEARCH

p21-Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase-independent Manner

(2013) Zhipeng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel Gene Targets and Functions of p21-Activated Kinase 1 during DNA Damage by Gene Expression Profiling

(2013) Mona Motwani et al.   PLoS One

Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-α plus IFN-γ on polystyrene and the role of p53 activation

(2012) Yan-Qing Guan et al.   BIOMATERIALS

p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model

(2012) H. Y. Chow et al.   CANCER RESEARCH

Comparative Analysis of Dynamic Cell Viability, Migration and Invasion Assessments by Novel Real-Time Technology and Classic Endpoint Assays

(2012) Ridha Limame et al.   PLoS One

Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours

(2011) Karolina Holm et al.   BREAST CANCER RESEARCH AND TREATMENT

P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth

(2011) Hong He et al.   CANCER LETTERS

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

(2011) Y Shrestha et al.   ONCOGENE

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

(2011) C. C. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights

(2010) Assia Merabet et al.   BIOCHEMICAL JOURNAL

P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways

(2010) Nhi Huynh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Rac–Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

(2010) L E Arias-Romero et al.   ONCOGENE

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

(2010) Z Wang et al.   ONCOGENE

A minority of foci or pan-nuclear apoptotic staining of  H2AX in the S phase after UV damage contain DNA double-strand breaks

(2010) S. de Feraudy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

(2010) B. W. Murray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone

(2009) S. Liu et al.   CANCER RESEARCH

Functional Analysis of 11q13.5 Amplicon Identifies Rsf-1 (HBXAP) as a Gene Involved in Paclitaxel Resistance in Ovarian Cancer

(2009) Jung Hye Choi et al.   CANCER RESEARCH

PAK1 interacts with β-catenin and is required for the regulation of the β-catenin signalling pathway by gastrins

(2008) Hong He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A tale of two Paks

(2008) Luis E. Arias-Romero et al.   BIOLOGY OF THE CELL

Validation of the p21-Activated Kinases as Targets for Inhibition in Neurofibromatosis Type 2

(2008) C. Yi et al.   CANCER RESEARCH

Amplification of 11q13 in ovarian carcinoma

(2008) Lindsay A. Brown et al.   GENES CHROMOSOMES & CANCER

Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma

(2008) Ben Davidson et al.   HUMAN PATHOLOGY

Scaffolding function of PAK in the PDK1–Akt pathway

(2008) Maiko Higuchi et al.   NATURE CELL BIOLOGY