- Home
- Publications
- Publication Search
- Publication Details
Title
Molecular pathology in real time
Authors
Keywords
Tumor heterogeneity, Evolution, Liquid biopsy, Limitation, Molecular pathology, Targeted therapy, Predictive marker, Resistance
Journal
CANCER AND METASTASIS REVIEWS
Volume 35, Issue 1, Pages 129-140
Publisher
Springer Nature
Online
2016-03-02
DOI
10.1007/s10555-016-9607-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Is Her-2 Status in the Primary Tumor Correlated with Matched Lymph Node Metastases in Patients with Gastric Cancer Undergoing Curative Gastrectomy?
- (2015) Fatih Selcukbiricik et al. Asian Pacific Journal of Cancer Prevention
- Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation
- (2015) Manuela Pinheiro et al. BRITISH JOURNAL OF CANCER
- Diversity of assessing circulating tumor cells (CTCs) emphasizes need for standardization: a CTC Guide to design and report trials
- (2015) S. Bünger et al. CANCER AND METASTASIS REVIEWS
- Clinico-pathological correlation of serial measurement of circulating tumor cells in 24 metastatic colorectal cancer patients receiving chemotherapy reveals interpatient heterogeneity correlated with CEA levels but independent of KRAS and BRAF mutation
- (2015) Avisnata Das et al. CANCER BIOLOGY & THERAPY
- Circulating Tumor DNA Outperforms Circulating Tumor Cells for KRAS Mutation Detection in Thoracic Malignancies
- (2015) M. B. Freidin et al. CLINICAL CHEMISTRY
- Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease
- (2015) Eleonor Olsson et al. EMBO Molecular Medicine
- Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: Evaluation of concordance between genomic and transcriptional profiles
- (2015) Stéphane Vignot et al. EUROPEAN JOURNAL OF CANCER
- Clinical relevance of regulatory T cells monitoring in the peripheral blood of ovarian cancer patients
- (2015) Tomáš Brtnický et al. HUMAN IMMUNOLOGY
- Circulating Cell-Free Tumour DNA in the Management of Cancer
- (2015) Glenn Francis et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach
- (2015) Moisés Blanco-Calvo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Discordances in HER2 status between primary gastric cancer and corresponding metastatic sites
- (2015) O. Gumusay et al. JAPANESE JOURNAL OF CLINICAL ONCOLOGY
- Early Prediction of Response to Tyrosine Kinase Inhibitors by Quantification of EGFR Mutations in Plasma of NSCLC Patients
- (2015) Antonio Marchetti et al. Journal of Thoracic Oncology
- The 2015 World Health Organization Classification of Lung Tumors
- (2015) William D. Travis et al. Journal of Thoracic Oncology
- Programmed Death-Ligand 1 Immunohistochemistry in Lung Cancer: In what state is this art?
- (2015) Keith M. Kerr et al. Journal of Thoracic Oncology
- Spatiotemporal T790M Heterogeneity in Individual Patients with EGFR-Mutant Non–Small-Cell Lung Cancer after Acquired Resistance to EGFR-TKI
- (2015) Akito Hata et al. Journal of Thoracic Oncology
- Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
- (2015) Antoni Ribas et al. LANCET ONCOLOGY
- Role of circulating-tumor DNA analysis in non-small cell lung cancer
- (2015) Tao Jiang et al. LUNG CANCER
- Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
- (2015) Giulia Siravegna et al. NATURE MEDICINE
- Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M
- (2015) Kenneth S Thress et al. NATURE MEDICINE
- Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma
- (2015) Michael A. Postow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
- (2015) Edward B. Garon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab versus Ipilimumab in Advanced Melanoma
- (2015) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
- (2015) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor
- (2015) Z. Piotrowska et al. Cancer Discovery
- Small cell lung cancer transformation and T790M mutation: complimentary roles in acquired resistance to kinase inhibitors in lung cancer
- (2015) Kenichi Suda et al. Scientific Reports
- Mutational Analysis of Circulating Tumor Cells from Colorectal Cancer Patients and Correlation with Primary Tumor Tissue
- (2015) Anna Lyberopoulou et al. PLoS One
- Classification of current anticancer immunotherapies
- (2015) Lorenzo Galluzzi et al. Oncotarget
- The Effects of Under 6 Hours of Formalin Fixation on Hormone Receptor and HER2 Expression in Invasive Breast Cancer
- (2014) Shona Kalkman et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Monitoring of epidermal growth factor receptor tyrosine kinase inhibitor-sensitizing and resistance mutations in the plasma DNA of patients with advanced non-small cell lung cancer during treatment with erlotinib
- (2014) Boe S. Sorensen et al. CANCER
- Circulating tumor cells
- (2014) Cristina Raimondi et al. CANCER BIOLOGY & THERAPY
- Discordance Rate of HER2 Status in Primary Gastric Carcinomas and Synchronous Lymph Node Metastases: A Multicenter Retrospective Analysis
- (2014) Antonio Ieni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Gefitinib Treatment in EGFR Mutated Caucasian NSCLC: Circulating-Free Tumor DNA as a Surrogate for Determination of EGFR Status
- (2014) Jean-Yves Douillard et al. Journal of Thoracic Oncology
- Tumour heterogeneity and the evolution of polyclonal drug resistance
- (2014) Rebecca A. Burrell et al. Molecular Oncology
- Discordance in Hormone Receptor Status Among Primary, Metastatic, and Second Primary Breast Cancers: Biological Difference or Misclassification?
- (2014) D. Sighoko et al. ONCOLOGIST
- Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
- (2014) C. Bettegowda et al. Science Translational Medicine
- Clinicopathological and prognostic significance of HER2 overexpression in gastric cancer: a meta-analysis of the literature
- (2014) Ji-wang Liang et al. TUMOR BIOLOGY
- Diagnostic value of circulating free DNA for the detection of EGFR mutation status in NSCLC: a systematic review and meta-analysis
- (2014) Jie Luo et al. Scientific Reports
- Combined HER2 analysis of biopsies and surgical specimens to optimize detection of trastuzumab-eligible patients in eso-gastric adenocarcinoma: a GERCOR study
- (2013) S. Watson et al. ANNALS OF ONCOLOGY
- Loss of HER2 positivity and prognosis after neoadjuvant therapy in HER2-positive breast cancer patients
- (2013) V. Guarneri et al. ANNALS OF ONCOLOGY
- First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients: a phase-IV, open-label, single-arm study
- (2013) J-Y Douillard et al. BRITISH JOURNAL OF CANCER
- A meta-analysis of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 discordance between primary breast cancer and metastases
- (2013) Gaetano Aurilio et al. EUROPEAN JOURNAL OF CANCER
- The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome
- (2013) Juana V. Martín-López et al. Familial Cancer
- Regulatory T cells, dendritic cells and neutrophils in patients with renal cell carcinoma
- (2013) Ivo Minárik et al. IMMUNOLOGY LETTERS
- Level ofHER2Gene Amplification Predicts Response and Overall Survival in HER2-Positive Advanced Gastric Cancer Treated With Trastuzumab
- (2013) Carlos Gomez-Martin et al. JOURNAL OF CLINICAL ONCOLOGY
- Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping
- (2013) Hye-Ryoun Kim et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Comparison of EGFR Signaling Pathway Somatic DNA Mutations Derived From Peripheral Blood and Corresponding Tumor Tissue of Patients with Advanced Non-Small-Cell Lung Cancer Using Liquidchip Technology
- (2013) Hui Zhang et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Transformation to “high grade” neuroendocrine carcinoma as an acquired drug resistance mechanism in EGFR-mutant lung adenocarcinoma
- (2013) S. Popat et al. LUNG CANCER
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis
- (2013) Jens Neumann et al. VIRCHOWS ARCHIV
- Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non-small cell lung cancer
- (2013) Hakan Akca et al. Cancer Genetics
- Her2/neu testing in gastric cancer: evaluating the risk of sampling errors
- (2012) V. S. Warneke et al. ANNALS OF ONCOLOGY
- Intratumor Heterogeneity: Evolution through Space and Time
- (2012) C. Swanton CANCER RESEARCH
- Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK-Positive Non-Small Cell Lung Cancer
- (2012) J. Tanizaki et al. CLINICAL CANCER RESEARCH
- Analysis of the Concordance in the EGFR Pathway Status Between Primary Tumors and Related Metastases of Colorectal Cancer Patients:Implications for Cancer Therapy
- (2012) P. Cejas et al. CURRENT CANCER DRUG TARGETS
- KRASandBRAFmutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue
- (2012) Bianca Mostert et al. INTERNATIONAL JOURNAL OF CANCER
- CNS metastases of breast cancer show discordant immunohistochemical phenotype compared to primary
- (2012) C. Bachmann et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The effect of cold ischemic time on the immunohistochemical evaluation of estrogen receptor, progesterone receptor and HER2 expression in invasive breast carcinoma
- (2012) Isil Z Yildiz-Aktas et al. MODERN PATHOLOGY
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
- (2012) K. Ohashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HER2 Amplification: A Potential Mechanism of Acquired Resistance to EGFR Inhibition in EGFR -Mutant Lung Cancers That Lack the Second-Site EGFR T790M Mutation
- (2012) Ken Takezawa et al. Cancer Discovery
- The Effect of Prolonged Fixation on the Immunohistochemical Evaluation of Estrogen Receptor, Progesterone Receptor, and HER2 Expression in Invasive Breast Cancer
- (2011) Leung Chu Tong et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
- (2011) L. V. Sequist et al. ANNALS OF ONCOLOGY
- HER2 discordance between primary breast cancer and its paired metastasis: tumor biology or test artefact? Insights through meta-analysis
- (2011) Nehmat Houssami et al. BREAST CANCER RESEARCH AND TREATMENT
- Dual-colour HER2/Chromosome 17 chromogenic in situ hybridisation assay enables accurate assessment of HER2 genomic status in gastric cancer and has potential utility in HER2 testing of biopsy samples
- (2011) B. Yan et al. JOURNAL OF CLINICAL PATHOLOGY
- A Noninvasive System for Monitoring Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors with Plasma DNA
- (2011) Tomomi Nakamura et al. Journal of Thoracic Oncology
- Epidermal Growth Factor Receptor Mutation Status in Circulating Free DNA in Serum: From IPASS, a Phase III Study of Gefitinib or Carboplatin/Paclitaxel in Non-small Cell Lung Cancer
- (2011) Koichi Goto et al. Journal of Thoracic Oncology
- Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A Review
- (2011) J. M. Baas et al. ONCOLOGIST
- Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
- (2011) L. V. Sequist et al. Science Translational Medicine
- Systematic Review on Hormone Receptor Testing in Breast Cancer
- (2011) Sharon Nofech-Mozes et al. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
- Effect of Delayed Formalin Fixation on Estrogen and Progesterone Receptors in Breast Cancer
- (2010) Jingxin Qiu et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
- (2010) M Gerlinger et al. BRITISH JOURNAL OF CANCER
- Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC
- (2010) Alexa B. Turke et al. CANCER CELL
- Breast Cancer Hormone Receptor Assay Results of Core Needle Biopsy and Modified Radical Mastectomy Specimens From the Same Patients
- (2010) Gemma B. Uy et al. Clinical Breast Cancer
- The Chromosomal Instability Pathway in Colon Cancer
- (2010) Maria S. Pino et al. GASTROENTEROLOGY
- Role of the Serrated Pathway in Colorectal Cancer Pathogenesis
- (2010) Barbara Leggett et al. GASTROENTEROLOGY
- A study of HER2 gene amplification and protein expression in gastric cancer
- (2010) B. Yan et al. JOURNAL OF CLINICAL PATHOLOGY
- Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
- (2010) Yung-Jue Bang et al. LANCET
- HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing
- (2010) Josef Rüschoff et al. VIRCHOWS ARCHIV
- Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome
- (2009) Jinyun Chen et al. CANCER CAUSES & CONTROL
- Loss of HER2 Amplification Following Trastuzumab-Based Neoadjuvant Systemic Therapy and Survival Outcomes
- (2009) E. A. Mittendorf et al. CLINICAL CANCER RESEARCH
- Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancers Dependent on the Epidermal Growth Factor Receptor Pathway
- (2009) Kim-Son H. Nguyen et al. Clinical Lung Cancer
- DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome
- (2009) George Poulogiannis et al. HISTOPATHOLOGY
- Delay to formalin fixation effect on breast biomarkers
- (2009) Thaer Khoury et al. MODERN PATHOLOGY
- KRASMutations As an Independent Prognostic Factor in Patients With Advanced Colorectal Cancer Treated With Cetuximab
- (2008) Astrid Lièvre et al. JOURNAL OF CLINICAL ONCOLOGY
- Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
- (2008) Helena Linardou et al. LANCET ONCOLOGY
- Detection of Mutations inEGFRin Circulating Lung-Cancer Cells
- (2008) Shyamala Maheswaran et al. NEW ENGLAND JOURNAL OF MEDICINE
- High Concordance of KRAS Status Between Primary Colorectal Tumors and Related Metastatic Sites: Implications for Clinical Practice
- (2008) D. Santini et al. ONCOLOGIST
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started