Circulating Cell-Free Tumour DNA in the Management of Cancer

PIK3CA mutations in serum DNA are predictive of recurrence in primary breast cancer patients

(2015) Chiya Oshiro et al.   BREAST CANCER RESEARCH AND TREATMENT

Detection ofK-rasgene mutation by liquid biopsy in patients with pancreatic cancer

(2015) Hideaki Kinugasa et al.   CANCER

Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening

(2015) Wybo Dondorp et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Circulating tumor DNA: new horizons for improving cancer treatment

(2015) Georgios D Lianos et al.   Future Oncology

Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery

(2015) Thomas Reinert et al.   GUT

Enhanced Ratio of Signals Enables Digital Mutation Scanning for Rare Allele Detection

(2015) Elena Castellanos-Rizaldos et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Highly Sensitive Droplet Digital PCR Method for Detection of EGFR-Activating Mutations in Plasma Cell–Free DNA from Patients with Advanced Non–Small Cell Lung Cancer

(2015) Guanshan Zhu et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146 958 pregnancies

(2015) H. Zhang et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

HER2 Genetic Heterogeneity in Gastric Cancer

(2015) Ann D. Treacy et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Genomic imbalances in circulating DNA in Hodgkin's lymphoma

(2015) Stefan Hohaus   Lancet Haematology

Non-invasive detection of genomic imbalances in Hodgkin/Reed-Sternberg cells in early and advanced stage Hodgkin's lymphoma by sequencing of circulating cell-free DNA: a technical proof-of-principle study

(2015) Peter Vandenberghe et al.   Lancet Haematology

The predictive value ofKRAS, NRAS, BRAF, PIK3CAand PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis

(2014) Christina Therkildsen et al.   ACTA ONCOLOGICA

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

(2014) L. De Mattos-Arruda et al.   ANNALS OF ONCOLOGY

Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer

(2014) F. Rothé et al.   ANNALS OF ONCOLOGY

Monitoring gastric cancer progression with circulating tumour DNA

(2014) T Hamakawa et al.   BRITISH JOURNAL OF CANCER

Immune Escape and Survival Mechanisms in Circulating Tumor Cells of Colorectal Cancer

(2014) Gunnar Steinert et al.   CANCER RESEARCH

Personalized treatments of cancer patients: A reality in daily practice, a costly dream or a shared vision of the future from the oncology community?

(2014) Monica Arnedos et al.   CANCER TREATMENT REVIEWS

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA

(2014) G. R. Oxnard et al.   CLINICAL CANCER RESEARCH

Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer

(2014) J. A. Beaver et al.   CLINICAL CANCER RESEARCH

Quantitative Cell-Free Circulating BRAFV600E Mutation Analysis by Use of Droplet Digital PCR in the Follow-up of Patients with Melanoma Being Treated with BRAF Inhibitors

(2014) M. F. Sanmamed et al.   CLINICAL CHEMISTRY

Liquid Biopsies: Genotyping Circulating Tumor DNA

(2014) Luis A. Diaz et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparison of KRAS mutation analysis of colorectal cancer samples by standard testing and next-generation sequencing

(2014) Nishi Kothari et al.   JOURNAL OF CLINICAL PATHOLOGY

Variation in pre-PCR processing of FFPE samples leads to discrepancies inBRAFandEGFRmutation detection: a diagnostic RING trial

(2014) Joshua R Kapp et al.   JOURNAL OF CLINICAL PATHOLOGY

RAS testing of colorectal carcinoma—a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group

(2014) Newton ACS Wong et al.   JOURNAL OF CLINICAL PATHOLOGY

KRAS mutations in tumor tissue and plasma by different assays predict survival of patients with metastatic colorectal cancer

(2014) Jian-Ming Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TP53 Mutational Status and Cetuximab Benefit in Rectal Cancer: 5-Year Results of the EXPERT-C Trial

(2014) Francesco Sclafani et al.   JNCI-Journal of the National Cancer Institute

FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial

(2014) Volker Heinemann et al.   LANCET ONCOLOGY

Development and Validation of a Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction Combined with Melting Analysis-Assay for Clinical JAK2 V617F Mutation Detection

(2014) Weiwei Liu et al.   Molecular Diagnosis & Therapy

Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types

(2014) Ronald Lebofsky et al.   Molecular Oncology

Clonal evolution in breast cancer revealed by single nucleus genome sequencing

(2014) Yong Wang et al.   NATURE

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load

(2014) Florent Mouliere et al.   Translational Oncology

Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade

(2014) Evan J Lipson et al.   Journal for ImmunoTherapy of Cancer

Dynamic Changes in Numbers and Properties of Circulating Tumor Cells and Their Potential Applications

(2014) Ju-Yu Tseng et al.   Cancers

Phase II trial of temsirolimus alone and in combination with irinotecan forKRASmutant metastatic colorectal cancer: Outcome and results ofKRASmutational analysis in plasma

(2013) Karen-Lise G. Spindler et al.   ACTA ONCOLOGICA

KRAS-mutated plasma DNA as predictor of outcome from irinotecan monotherapy in metastatic colorectal cancer

(2013) K G Spindler et al.   BRITISH JOURNAL OF CANCER

Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non-small cell lung cancer: Focus on epidermal growth factor receptor mutation testing and mutation-positive patients

(2013) Monic Roengvoraphoj et al.   CANCER TREATMENT REVIEWS

Reducing Sequence Artifacts in Amplicon-Based Massively Parallel Sequencing of Formalin-Fixed Paraffin-Embedded DNA by Enzymatic Depletion of Uracil-Containing Templates

(2013) H. Do et al.   CLINICAL CHEMISTRY

Digital PCR as a Novel Technology and Its Potential Implications for Molecular Diagnostics

(2013) J. F. Huggett et al.   CLINICAL CHEMISTRY

Multiplex Picodroplet Digital PCR to Detect KRAS Mutations in Circulating DNA from the Plasma of Colorectal Cancer Patients

(2013) V. Taly et al.   CLINICAL CHEMISTRY

Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients

(2013) Diego M Marzese et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Detection rate and prognostic value of circulating tumor cells and circulating tumor DNA in metastatic uveal melanoma

(2013) François-Clément Bidard et al.   INTERNATIONAL JOURNAL OF CANCER

EGFR Mutations in Surgically Resected Fresh Specimens from 697 Consecutive Chinese Patients with Non-Small Cell Lung Cancer and Their Relationships with Clinical Features

(2013) Yuanyang Lai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genotyping and Genomic Profiling of Non–Small-Cell Lung Cancer: Implications for Current and Future Therapies

(2013) Tianhong Li et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular genetic testing for lung adenocarcinomas: a practical approach to clinically relevant mutations and translocations

(2013) Sanja Dacic   JOURNAL OF CLINICAL PATHOLOGY

Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping

(2013) Hye-Ryoun Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Somatic alterations as the basis for resistance to targeted therapies

(2013) Brian G Blair et al.   JOURNAL OF PATHOLOGY

The genetic complexity of common cancers and the promise of personalized medicine: is there any hope?

(2013) Monica Arnedos et al.   JOURNAL OF PATHOLOGY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted therapy for melanoma: rational combinatorial approaches

(2013) L N Kwong et al.   ONCOGENE

Levels of cell-free DNA and plasma KRAS during treatment of advanced NSCLC

(2013) ANNELI DOWLER NYGAARD et al.   ONCOLOGY REPORTS

Quantitative Identification of Mutant Alleles Derived from Lung Cancer in Plasma Cell-Free DNA via Anomaly Detection Using Deep Sequencing Data

(2013) Yoji Kukita et al.   PLoS One

Discordant noninvasive prenatal testing results in a patient subsequently diagnosed with metastatic disease

(2013) C. Michael Osborne et al.   PRENATAL DIAGNOSIS

Evolutionary dynamics of cancer in response to targeted combination therapy

(2013) Ivana Bozic et al.   eLife

Modified PNA-PCR method

(2012) Shaorong Yu et al.   CANCER BIOLOGY & THERAPY

Quantitative Cell-Free DNA, KRAS, and BRAF Mutations in Plasma from Patients with Metastatic Colorectal Cancer during Treatment with Cetuximab and Irinotecan

(2012) K.-L. G. Spindler et al.   CLINICAL CANCER RESEARCH

Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

(2012) M. J. Higgins et al.   CLINICAL CANCER RESEARCH

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

(2012) Luis A. Diaz Jr et al.   NATURE

Multi-Purpose Utility of Circulating Plasma DNA Testing in Patients with Advanced Cancers

(2012) Geraldine Perkins et al.   PLoS One

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

(2012) T. Forshew et al.   Science Translational Medicine

Effectiveness of Tyrosine Kinase Inhibitors on "Uncommon" Epidermal Growth Factor Receptor Mutations of Unknown Clinical Significance in Non-Small Cell Lung Cancer

(2011) J.-Y. Wu et al.   CLINICAL CANCER RESEARCH

Canadian Expert Group consensus recommendations: KRAS testing in colorectal cancer

(2011) F. Aubin et al.   Current Oncology

Prognostic and Clinicopathologic Associations of OncogenicBRAFin Metastatic Melanoma

(2011) Georgina V. Long et al.   JOURNAL OF CLINICAL ONCOLOGY

Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients

(2011) Carmelo Tibaldi et al.   Journal of Thoracic Oncology

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment

(2010) E. Van Cutsem et al.   ANNALS OF ONCOLOGY

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer

(2010) Ruth E. Board et al.   BREAST CANCER RESEARCH AND TREATMENT

Plasma cell-free DNA in ovarian cancer

(2010) Aparna A. Kamat et al.   CANCER

Germ-Line and Somatic Presentations of the EGFR T790M Mutation in Lung Cancer

(2010) Ludmila Prudkin et al.   Journal of Thoracic Oncology

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Prospective Diagnostic Accuracy Study of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography, Multidetector Row Computed Tomography, and Magnetic Resonance Imaging in Primary Diagnosis and Staging of Pancreatic Cancer

(2009) Saila P. Kauhanen et al.   ANNALS OF SURGERY

Detection and Monitoring of Cell-Free DNA in Blood of Patients with Colorectal Cancer

(2009) Heidi Schwarzenbach et al.   Annals of the New York Academy of Sciences

American Society of Clinical Oncology Provisional Clinical Opinion: Testing forKRASGene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti–Epidermal Growth Factor Receptor Monoclonal Antibody Therapy

(2009) Carmen J. Allegra et al.   JOURNAL OF CLINICAL ONCOLOGY

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE