Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner

Treating Disease at the RNA Level with Oligonucleotides

(2019) Arthur A. Levin   NEW ENGLAND JOURNAL OF MEDICINE

A tRNA half modulates translation as stress response in Trypanosoma brucei

(2019) Roger Fricker et al.   Nature Communications

Serum-free media supplements carry miRNAs that co-purify with extracellular vesicles

(2019) Martin Auber et al.   Journal of Extracellular Vesicles

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling

(2018) Maria D Giraldez et al.   NATURE BIOTECHNOLOGY

Dimerization confers increased stability to nucleases in 5′ halves from glycine and glutamic acid tRNAs

(2018) Juan Pablo Tosar et al.   NUCLEIC ACIDS RESEARCH

Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

(2018) Qiang Cai et al.   SCIENCE

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

(2018) Ryosuke Kojima et al.   Nature Communications

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm

(2018) Upasna Sharma et al.   DEVELOPMENTAL CELL

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation

(2018) Ni-Ting Chiou et al.   Cell Reports

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Antisense oligonucleotides: the next frontier for treatment of neurological disorders

(2017) Carlo Rinaldi et al.   Nature Reviews Neurology

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

(2017) Matthew J. Shurtleff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

(2017) Zhiyun Wei et al.   Nature Communications

Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

(2017) Shawn M. Lyons et al.   Nature Communications

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

(2016) Shawn M. Lyons et al.   NUCLEIC ACIDS RESEARCH

RNA biology of angiogenin: Current state and perspectives

(2016) Shawn M. Lyons et al.   RNA Biology

Small RNA Modifications: Integral to Function and Disease

(2016) Xudong Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Fetal Bovine Serum RNA Interferes with the Cell Culture derived Extracellular RNA

(2016) Zhiyun Wei et al.   Scientific Reports

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Efficient and quantitative high-throughput tRNA sequencing

(2015) Guanqun Zheng et al.   NATURE METHODS

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines

(2015) J. P. Tosar et al.   NUCLEIC ACIDS RESEARCH

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment

(2015) Kirsten Ridder et al.   OncoImmunology

Microvesicle-mediated delivery of transforming growth factor β1 siRNA for the suppression of tumor growth in mice

(2014) Yaqin Zhang et al.   BIOMATERIALS

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mining of public sequencing databases supports a non-dietary origin for putative foreign miRNAs: underestimated effects of contamination in NGS

(2014) J. P. Tosar et al.   RNA

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

(2014) Danijela Koppers-Lalic et al.   Cell Reports

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

(2013) Joseph M Dhahbi et al.   BMC GENOMICS

Microvesicle-mediated Transfer of MicroRNA-150 from Monocytes to Endothelial Cells Promotes Angiogenesis

(2013) Jing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Slicing tRNAs to boost functional ncRNA diversity

(2013) Jennifer Gebetsberger et al.   RNA Biology

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

A population of tRNA-derived small RNAs is actively produced in Trypanosoma cruzi and recruited to specific cytoplasmic granules

(2010) Maria Rosa Garcia-Silva et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY