Proteinase K resistant cores of prions and amyloids

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration

(2019) Carlo Scialò et al.   Viruses-Basel

Prion Variants of Yeast are Numerous, Mutable, and Segregate on Growth, Affecting Prion Pathogenesis, Transmission Barriers, and Sensitivity to Anti-Prion Systems

(2019) Reed Wickner et al.   Viruses-Basel

Cryo-Electron Microscopy Uncovers Key Residues within the Core of Alpha-Synuclein Fibrils

(2019) Ritobrita Chakraborty et al.   ACS Chemical Neuroscience

Yeast Sup35 Prion Structure: Two Types, Four Parts, Many Variants

(2019) Alexander Dergalev et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments

(2019) Laura Cracco et al.   Acta Neuropathologica Communications

Full atomistic model of prion structure and conversion

(2019) Giovanni Spagnolli et al.   PLoS Pathogens

Molecular basis for diversification of yeast prion strain conformation

(2018) Yumiko Ohhashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

Variably protease-sensitive prionopathy presenting within ALS/FTD spectrum

(2018) Mikel Vicente-Pascual et al.   Annals of Clinical and Translational Neurology

Recent advances in the histo-molecular pathology of human prion disease

(2018) Simone Baiardi et al.   BRAIN PATHOLOGY

Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register

(2017) Kendra K. Frederick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transmissibility of Gerstmann–Sträussler–Scheinker syndrome in rodent models: New insights into the molecular underpinnings of prion infectivity

(2016) Romolo Nonno et al.   Prion

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

(2016) Ester Vázquez-Fernández et al.   PLoS Pathogens

Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus

(2015) Kendra K. Frederick et al.   CELL

Locating folds of the in-register parallel  -sheet of the Sup35p prion domain infectious amyloid

(2014) A. Gorkovskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-associated activity contributes to the severity and toxicity of a prion phenotype

(2014) John A. Pezza et al.   Nature Communications

The prion protein protease sensitivity, stability and seeding activity in variably protease sensitive prionopathy brain tissue suggests molecular overlaps with sporadic Creutzfeldt-Jakob disease

(2014) Alexander H Peden et al.   Acta Neuropathologica Communications

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress

(2012) G. Suzuki et al.   SCIENCE

Radically Different Amyloid Conformations Dictate the Seeding Specificity of a Chimeric Sup35 Prion

(2011) Catherine K. Foo et al.   JOURNAL OF MOLECULAR BIOLOGY

Variably protease-sensitive prionopathy: A new sporadic disease of the prion protein

(2010) Wen-Quan Zou et al.   ANNALS OF NEUROLOGY

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Two Prion Variants of Sup35p Have In-Register Parallel β-Sheet Structures, Independent of Hydration

(2009) Frank Shewmaker et al.   BIOCHEMISTRY

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Natural and synthetic prion structure from X-ray fiber diffraction

(2009) H. Wille et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel human disease with abnormal prion protein sensitive to protease

(2008) Pierluigi Gambetti et al.   ANNALS OF NEUROLOGY

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS

Strain-specific sequences required for yeast [PSI+] prion propagation

(2008) H.-Y. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE