Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration

ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

(2018) W. Peelaerts et al.   CELL AND TISSUE RESEARCH

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease

(2018) Carlo Condello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of cellular prion protein in interneuronal amyloid transmission

(2018) José A. del Río et al.   PROGRESS IN NEUROBIOLOGY

Artificial strain of human prions created in vitro

(2018) Chae Kim et al.   Nature Communications

Molecular subtypes of Alzheimer’s disease

(2018) Giuseppe Di Fede et al.   Scientific Reports

Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms

(2018) Hilary A. Weismiller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Prion Selection and Adaptation

(2018) Edoardo Bistaffa et al.   MOLECULAR NEUROBIOLOGY

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

(2018) Silvia A. Purro et al.   NATURE

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

(2018) Sílvia Porta et al.   Nature Communications

The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases

(2017) Guiliana Soraya Victoria et al.   JOURNAL OF CELL BIOLOGY

Prying into the Prion Hypothesis for Parkinson's Disease

(2017) Patrik Brundin et al.   JOURNAL OF NEUROSCIENCE

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Variant Creutzfeldt–Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129

(2017) Tzehow Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

(2017) Jay Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque

(2017) Emmanuel E. Comoy et al.   Nature Communications

TDP-43 Prions

(2017) Takashi Nonaka et al.   Cold Spring Harbor Perspectives in Medicine

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

(2017) Suzana Aulić et al.   Scientific Reports

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

(2016) Saïda Abounit et al.   EMBO JOURNAL

The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer’s Disease

(2016) Brittany N. Dugger et al.   JOURNAL OF ALZHEIMERS DISEASE

Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils

(2016) Shotaro Shimonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alpha-synuclein structure, functions, and interactions

(2016) FatemehNouri Emamzadeh   Journal of Research in Medical Sciences

In vitro prion-like behaviour of TDP-43 in ALS

(2016) Phillip Smethurst et al.   NEUROBIOLOGY OF DISEASE

Exosomes in Alzheimer's disease

(2016) Tarja Malm et al.   NEUROCHEMISTRY INTERNATIONAL

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory

(2016) José A. del Río et al.   Prion

Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease

(2016) Mark Cohen et al.   Prion

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Cell Biology of Prions and Prionoids: A Status Report

(2016) Adriano Aguzzi et al.   TRENDS IN CELL BIOLOGY

Tau Structures

(2016) Jesus Avila et al.   Frontiers in Aging Neuroscience

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Phosphorylation induces distinct alpha-synuclein strain formation

(2016) Meng-Rong Ma et al.   Scientific Reports

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

(2015) Michiyo Iba et al.   ACTA NEUROPATHOLOGICA

Neurodegenerative Diseases: Expanding the Prion Concept

(2015) Lary C. Walker et al.   Annual Review of Neuroscience

Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

(2015) Mark L. Cohen et al.   BRAIN

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome

(2015) Lan Ye et al.   BRAIN PATHOLOGY

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

(2015) Eve Peeraer et al.   NEUROBIOLOGY OF DISEASE

Review: Prion-like mechanisms of transactive response DNA binding protein of 43 kDa (TDP-43) in amyotrophic lateral sclerosis (ALS)

(2015) Phillip Smethurst et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From nucleation to widespread propagation: A prion-like concept for ALS

(2015) Zuzanna Maniecka et al.   VIRUS RESEARCH

Synthetic prions with novel strain-specified properties

(2015) Fabio Moda et al.   PLoS Pathogens

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Defined α-synuclein prion-like molecular assemblies spreading in cell culture

(2014) Suzana Aulić et al.   BMC NEUROSCIENCE

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

(2014) Sarah K. Fritschi et al.   BRAIN

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

(2014) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Factors Contribute to the Peripheral Induction of Cerebral  -Amyloidosis

(2014) Y. S. Eisele et al.   JOURNAL OF NEUROSCIENCE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Aggregate-Depleted Brain Fails to Induce Aβ Deposition in a Mouse Model of Alzheimer's Disease

(2014) Claudia Duran-Aniotz et al.   PLoS One

Distinct synthetic A  prion strains producing different amyloid deposits in bigenic mice

(2014) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis

(2014) Paul C Donaghy et al.   Alzheimers Research & Therapy

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

(2014) Simon Dujardin et al.   Acta Neuropathologica Communications

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid

(2013) Eileen H. Bigio et al.   ACTA NEUROPATHOLOGICA

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt–Jakob disease

(2013) Matthew T. Bishop et al.   BRAIN

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice

(2013) Götz Heilbronner et al.   EMBO REPORTS

Changes in prion replication environment cause prion strain mutation

(2013) Nuria Gonzalez-Montalban et al.   FASEB JOURNAL

De novo generation of infectious prions with bacterially expressed recombinant prion protein

(2013) Zhihong Zhang et al.   FASEB JOURNAL

Structural Transformation of the Amyloidogenic Core Region of TDP-43 Protein Initiates Its Aggregation and Cytoplasmic Inclusion

(2013) Lei-Lei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Prion Disease Associated with Diarrhea and Autonomic Neuropathy

(2013) Simon Mead et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transmission of multiple system atrophy prions to transgenic mice

(2013) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug resistance confounding prion therapeutics

(2013) D. B. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

(2013) Takashi Nonaka et al.   Cell Reports

Parkinson's Disease and Parkinsonism: Neuropathology

(2013) D. W. Dickson   Cold Spring Harbor Perspectives in Medicine

Incidence and Pathology of Synucleinopathies and Tauopathies Related to Parkinsonism

(2013) Rodolfo Savica et al.   JAMA Neurology

The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ

(2013) Hannu Kalimo et al.   Acta Neuropathologica Communications

Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo

(2013) Claudia Duran-Aniotz et al.   Acta Neuropathologica Communications

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

(2013) Amanda N Sacino et al.   Acta Neuropathologica Communications

TDP-43 skeins show properties of amyloid in a subset of ALS cases

(2012) John L. Robinson et al.   ACTA NEUROPATHOLOGICA

Amyotrophic lateral sclerosis and organ donation: Is there risk of disease transmission?

(2012) Brandon B. Holmes et al.   ANNALS OF NEUROLOGY

Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

(2012) Eric Heuer et al.   CURRENT PHARMACEUTICAL DESIGN

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers

(2012) M. Scholl et al.   NEUROLOGY

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Review: Creutzfeldt-Jakob disease: prion protein type, disease phenotype and agent strain

(2012) M. W. Head et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Rabbits are not resistant to prion infection

(2012) F. Chianini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain

(2011) Tsuyoshi Hamaguchi et al.   ACTA NEUROPATHOLOGICA

A harmonized classification system for FTLD-TDP pathology

(2011) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Variations in Filament Conformation Dictate Seeding Barrier between Three- and Four-Repeat Tau

(2011) Paul D. Dinkel et al.   BIOCHEMISTRY

The anatomy of cognitive impairment in amyotrophic lateral sclerosis: More than frontal lobe dysfunction

(2011) Stella Tsermentseli et al.   CORTEX

Distinguishing Alzheimer’s disease from other major forms of dementia

(2011) Stella Karantzoulis et al.   Expert Review of Neurotherapeutics

A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions

(2011) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of a New Form of Human PrPScin Vitroby Interspecies Transmission from Cervid Prions

(2011) Marcelo A. Barria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Transformation and Selection of Synthetic Prion Strains

(2011) Sina Ghaemmaghami et al.   JOURNAL OF MOLECULAR BIOLOGY

The Frontotemporal Syndromes of ALS. Clinicopathological Correlates

(2011) Michael Joseph Strong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

(2011) Rebecca F. Rosen et al.   JOURNAL OF NEUROCHEMISTRY

Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

(2011) F. Langer et al.   JOURNAL OF NEUROSCIENCE

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

(2011) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

De novo induction of amyloid-β deposition in vivo

(2011) R Morales et al.   MOLECULAR PSYCHIATRY

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

An overview of animal prion diseases

(2011) Muhammad Imran et al.   Virology Journal

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis

(2010) Brian C. Kraemer et al.   ACTA NEUROPATHOLOGICA

Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia

(2010) A. PEDEN et al.   HAEMOPHILIA

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

(2010) C. Lagier-Tourenne et al.   HUMAN MOLECULAR GENETICS

Three- and Four-repeat Tau Coassemble into Heterogeneous Filaments

(2010) Ayisha Siddiqua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeded Aggregation and Toxicity of α-Synuclein and Tau

(2010) Takashi Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-secretases: from cell biology to therapeutic strategies

(2010) Bruno A Bergmans et al.   LANCET NEUROLOGY

The benefits and limitations of animal models for translational research in neurodegenerative diseases

(2010) Mathias Jucker   NATURE MEDICINE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Darwinian Evolution of Prions in Cell Culture

(2010) J. Li et al.   SCIENCE

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer’s disease

(2009) Rebecca F. Rosen et al.   ACTA NEUROPATHOLOGICA

Prion protein misfolding and disease

(2009) Roger A Moore et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis

(2009) Lien-Szu Wu et al.   GENESIS

TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development

(2009) Chantelle F. Sephton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

(2009) Brian S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmissions of variant Creutzfeldt-Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type mice

(2009) D. L. Ritchie et al.   JOURNAL OF GENERAL VIROLOGY

TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons

(2009) Iñigo Casafont et al.   JOURNAL OF STRUCTURAL BIOLOGY

Multiple system atrophy: an update

(2009) Nadia Stefanova et al.   LANCET NEUROLOGY

Beyond the prion principle

(2009) Adriano Aguzzi   NATURE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

MRI lesion profiles in sporadic Creutzfeldt-Jakob disease

(2009) B. Meissner et al.   NEUROLOGY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and construction of diverse mammalian prion strains

(2009) D. W. Colby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of cerebral  -amyloidosis: Intracerebral versus systemic A  inoculation

(2009) Y. S. Eisele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2008) Masato Hasegawa et al.   ANNALS OF NEUROLOGY

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

(2008) Clifford R. Jack et al.   BRAIN

Crossing the Species Barrier by PrPSc Replication In Vitro Generates Unique Infectious Prions

(2008) Joaquín Castilla et al.   CELL

Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change

(2008) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau exon 10 alternative splicing and tauopathies

(2008) Fei Liu et al.   Molecular Neurodegeneration

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis

(2008) Nicola J. Rutherford et al.   PLoS Genetics