A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy

The Human Transcription Factors

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The Reactome Pathway Knowledgebase

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Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

(2017) Raymond Dingledine et al.   Scientific Data

Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

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Mutations in the GABA Transporter SLC6A1 Cause Epilepsy with Myoclonic-Atonic Seizures

(2015) Gemma L. Carvill et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A definition and classification of status epilepticus - Report of the ILAE Task Force on Classification of Status Epilepticus

(2015) Eugen Trinka et al.   EPILEPSIA

JAK/STAT pathway regulation of GABA A receptor expression after differing severities of experimental TBI

(2015) Daniel J. Raible et al.   EXPERIMENTAL NEUROLOGY

Molecular mechanisms of epilepsy

(2015) Kevin Staley   NATURE NEUROSCIENCE

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2

(2015) Maupali Dasgupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

(2015) Michael R. Johnson et al.   Nature Communications

Seizures and Epilepsy: An Overview for Neuroscientists

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What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory

(2014) Philipp A. Steffen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing

(2014) Katelin F. Hansen et al.   Scientific Reports

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

(2014) Shawn McClelland et al.   eLife

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

(2013) Kyle D. Konze et al.   ACS Chemical Biology

Weaver syndrome andEZH2mutations: Clarifying the clinical phenotype

(2013) Katrina Tatton-Brown et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

(2013) Rebecca L. Williams-Karnesky et al.   JOURNAL OF CLINICAL INVESTIGATION

The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy

(2013) H.L. Grabenstatter et al.   NEUROBIOLOGY OF DISEASE

Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy

(2013) Gumei Liu et al.   NEURON

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

(2013) J. Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

(2013) Andrew T. Kwon et al.   G3-Genes Genomes Genetics

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Transcription factors: from enhancer binding to developmental control

(2012) François Spitz et al.   NATURE REVIEWS GENETICS

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Mutations in EZH2 Cause Weaver Syndrome

(2011) William T. Gibson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

“Jasper’s Basic Mechanisms of the Epilepsies” Workshop

(2010) Jeffrey L. Noebels et al.   EPILEPSIA

Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance

(2010) M. Stapels et al.   Science Signaling

Molecular mechanisms of pluripotency and reprogramming

(2010) Jie Na et al.   Stem Cell Research & Therapy

Preventing and treating posttraumatic seizures: The human experience

(2009) Nancy R. Temkin   EPILEPSIA

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology

The cohesin complex and its roles in chromosome biology

(2008) J.-M. Peters et al.   GENES & DEVELOPMENT