What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory

A rapid and efficient method to purify proteins at replication forks under native conditions

(2016) Kai Him Thomas Leung et al.   BIOTECHNIQUES

Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing

(2014) F. Tie et al.   DEVELOPMENT

Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites

(2013) Jian Yan et al.   CELL

Chromatin dynamics at the replication fork: there's more to life than histones

(2013) Iestyn Whitehouse et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes

(2013) J. M. Caravaca et al.   GENES & DEVELOPMENT

Variable Requirements for DNA-Binding Proteins at Polycomb-Dependent Repressive Regions in Human HOX Clusters

(2013) Caroline J. Woo et al.   MOLECULAR AND CELLULAR BIOLOGY

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

(2013) Jeffrey A. Simon et al.   MOLECULAR CELL

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites

(2013) Wendy A. Kellner et al.   NUCLEIC ACIDS RESEARCH

Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin

(2013) Philipp A. Steffen et al.   NUCLEIC ACIDS RESEARCH

Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication

(2013) Javier Peña-Diaz et al.   NUCLEIC ACIDS RESEARCH

A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb

(2013) A. R. Pengelly et al.   SCIENCE

Mitotic bookmarking by transcription factors

(2013) Stephan Kadauke et al.   Epigenetics & Chromatin

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory

(2013) William H. Light et al.   PLOS BIOLOGY

PcG-Mediated Higher-Order Chromatin Structures Modulate Replication Programs at the Drosophila BX-C

(2013) Federica Lo Sardo et al.   PLoS Genetics

Cohesin and Polycomb Proteins Functionally Interact to Control Transcription at Silenced and Active Genes

(2013) Cheri A. Schaaf et al.   PLoS Genetics

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Memories from the Polycomb Group Proteins

(2012) Chiara Lanzuolo et al.   Annual Review of Genetics

Histone H3 phosphorylation – A versatile chromatin modification for different occasions

(2012) Anna Sawicka et al.   BIOCHIMIE

Epigenetics meets mathematics: Towards a quantitative understanding of chromatin biology

(2012) Philipp A. Steffen et al.   BIOESSAYS

Factor mediated gene priming in pluripotent stem cells sets the stage for lineage specification

(2012) Niall Dillon   BIOESSAYS

Dynamics and Memory of Heterochromatin in Living Cells

(2012) Nathaniel A. Hathaway et al.   CELL

A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy

(2012) Daphne S. Cabianca et al.   CELL

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

Tissue-Specific Mitotic Bookmarking by Hematopoietic Transcription Factor GATA1

(2012) Stephan Kadauke et al.   CELL

Concerted epigenetic signatures inheritance at PcG targets through replication

(2012) Chiara Lanzuolo et al.   CELL CYCLE

Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs

(2012) Emily Brookes et al.   Cell Stem Cell

Inner workings and regulatory inputs that control Polycomb repressive complex 2

(2012) M. Maggie O’Meara et al.   CHROMOSOMA

Transcription in the Absence of Histone H3.2 and H3K4 Methylation

(2012) Martina Hödl et al.   CURRENT BIOLOGY

Histone H2A monoubiquitination and Polycomb repression

(2012) Johanna C. Scheuermann et al.   FLY

In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells

(2012) J. P. Fonseca et al.   GENES & DEVELOPMENT

Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting

(2012) P. Arnold et al.   GENOME RESEARCH

A Bridging Model for Persistence of a Polycomb Group Protein Complex through DNA Replication In Vitro

(2012) Stanley M. Lo et al.   MOLECULAR CELL

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

(2012) Rodrigo Bermejo et al.   MOLECULAR CELL

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polycomb Group Proteins Bind an engrailed PRE in Both the “ON” and “OFF” Transcriptional States of engrailed

(2012) Kristofor K. Langlais et al.   PLoS One

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

(2012) B. N. Devaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation

(2012) W. Yuan et al.   SCIENCE

Histone modifications and mitosis: countermarks, landmarks, and bookmarks

(2012) Fangwei Wang et al.   TRENDS IN CELL BIOLOGY

Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity

(2012) Mitsuhiro Endoh et al.   PLoS Genetics

A Polycomb Group Protein Is Retained at Specific Sites on Chromatin in Mitosis

(2012) Nicole E. Follmer et al.   PLoS Genetics

Enhancer-PRE communication contributes to the expansion of gene expression domains in proliferating primordia

(2011) L. Perez et al.   DEVELOPMENT

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

(2011) Magnus D Lynch et al.   EMBO JOURNAL

A model for mitotic inheritance of histone lysine methylation

(2011) Mo Xu et al.   EMBO REPORTS

Crystal Structure of the Human Histone Methyltransferase ASH1L Catalytic Domain and Its Implications for the Regulatory Mechanism

(2011) Sojin An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

(2011) Rui Zhao et al.   NATURE CELL BIOLOGY

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dual Function of Histone H3 Lysine 36 Methyltransferase ASH1 in Regulation of Hox Gene Expression

(2011) Yujiro Tanaka et al.   PLoS One

Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners

(2011) G. Strubbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment

(2011) Helena Okulski et al.   Epigenetics & Chromatin

Patterns and Mechanisms of Ancestral Histone Protein Inheritance in Budding Yeast

(2011) Marta Radman-Livaja et al.   PLOS BIOLOGY

PcG Complexes Set the Stage for Epigenetic Inheritance of Gene Silencing in Early S Phase before Replication

(2011) Chiara Lanzuolo et al.   PLoS Genetics

A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness

(2010) Caroline J. Woo et al.   CELL

The Protein Composition of Mitotic Chromosomes Determined Using Multiclassifier Combinatorial Proteomics

(2010) Shinya Ohta et al.   CELL

Methylation of H3K4 Is Required for Inheritance of Active Transcriptional States

(2010) Tetsuya Muramoto et al.   CURRENT BIOLOGY

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes

(2010) Radhika A Varier et al.   EMBO JOURNAL

Epigenetic regulation of vertebrateHoxgenes: A dynamic equilibrium

(2010) Natalia Soshnikova et al.   Epigenetics

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

(2010) S. Kaneko et al.   GENES & DEVELOPMENT

Polycomb preferentially targets stalled promoters of coding and noncoding transcripts

(2010) D. Enderle et al.   GENOME RESEARCH

Identification and Characterization ofBmi-1-responding Element within the Humanp16Promoter

(2010) Sha Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic control of embryonic stem cell fate

(2010) Nicolaj Strøyer Christophersen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantitative Mass Spectrometry of Histones H3.2 and H3.3 inSuz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36

(2010) Hye Ryung Jung et al.   MOLECULAR & CELLULAR PROTEOMICS

Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation

(2010) Simmi Suman Gehani et al.   MOLECULAR CELL

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

(2010) Ragnhild Eskeland et al.   MOLECULAR CELL

Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

(2010) Shuai Chen et al.   NATURE CELL BIOLOGY

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

(2010) Diego Pasini et al.   NUCLEIC ACIDS RESEARCH

Non-coding RNAs in Polycomb/Trithorax regulation

(2010) Betül Hekimoglu et al.   RNA Biology

Chromatin Higher-order Structure and Dynamics

(2010) C. L. Woodcock et al.   Cold Spring Harbor Perspectives in Biology

GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

(2010) Eric M. Mendenhall et al.   PLoS Genetics

Alternative Epigenetic Chromatin States of Polycomb Target Genes

(2010) Yuri B. Schwartz et al.   PLoS Genetics

Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro

(2009) Nicole J. Francis et al.   CELL

A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain

(2009) Angela Sing et al.   CELL

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing

(2009) F. Tie et al.   DEVELOPMENT

A physiological role for gene loops in yeast

(2009) Jean-Philippe Lainé et al.   GENES & DEVELOPMENT

Brd4 Marks Select Genes on Mitotic Chromatin and Directs Postmitotic Transcription

(2009) Anup Dey et al.   MOLECULAR BIOLOGY OF THE CELL

A Reconfigured Pattern of MLL Occupancy within Mitotic Chromatin Promotes Rapid Transcriptional Reactivation Following Mitotic Exit

(2009) Gerd A. Blobel et al.   MOLECULAR CELL

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Epigenetic inheritance during the cell cycle

(2009) Aline V. Probst et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In Brief

(2009)   NATURE REVIEWS NEUROSCIENCE

Establishment of Histone Modifications after Chromatin Assembly

(2009) Annette N. D. Scharf et al.   NUCLEIC ACIDS RESEARCH

Talking to chromatin: post-translational modulation of polycomb group function

(2009) Hanneke EC Niessen et al.   Epigenetics & Chromatin

How does noncoding transcription regulate Hox genes?

(2008) Adelheid Lempradl et al.   BIOESSAYS

Chromatin state maps: new technologies, new insights

(2008) Eric M Mendenhall et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The role of Polycomb-group response elements in regulation of engrailed transcription in Drosophila

(2008) S. K. DeVido et al.   DEVELOPMENT

The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity

(2008) K. Laue et al.   DEVELOPMENT

Polycomb Group Protein-associated Chromatin Is Reproduced in Post-mitotic G1Phase and Is Required for S Phase Progression

(2008) Takahiro Aoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs

(2008) Gabriella Kozma et al.   MOLECULAR GENETICS AND GENOMICS

A model for transmission of the H3K27me3 epigenetic mark

(2008) Klaus H. Hansen et al.   NATURE CELL BIOLOGY

Characterization of new regulatory elements within the Drosophila bithorax complex

(2008) S. Perez-Lluch et al.   NUCLEIC ACIDS RESEARCH

Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences

(2008) C. Vincenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA