Article
Plant Sciences
Xiaofen Li, Jiyi Liang, Anquan Qin, Tao Wang, Sili Liu, Wei Li, Chuqiao Yuan, Liping Qu, Wenjun Zou
Summary: This study investigated the potential protective effect of DXXK against chronic cardiotoxicity induced by DOX. The results showed that DXXK could alleviate DOX-induced cardiotoxicity and reduce oxidative stress and inflammation by regulating HIF-1 alpha and NF-Kappa B p65.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sudha Sharma, Foram Patel, Hosne Ara, Ezra Bess, Alika Shum, Susmita Bhattarai, Utsab Subedi, Daquonte Sanard Bell, Md. Shenuarin Bhuiyan, Hong Sun, Ines Batinic-Haberle, Manikandan Panchatcharam, Sumitra Miriyala
Summary: This study determined the role of a superoxide dismutase mimetic MnTnBuOE-2-PyP5+ (MnP) in the degradation of rotenone-induced 4-HNE aggresomes in HL-1 cardiomyocytes. The results showed that pre-treatment with MnP attenuated ROS formation, 4-HNE aggresome accumulation, and autophagosome formation induced by rotenone. Furthermore, MnP also reduced tubulin hyperacetylation and cell death caused by disruption of autophagy in HL-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Nemat Ali, Abdullah F. AlAsmari, Faisal Imam, Mohammad Z. Ahmed, Faleh Alqahtani, Metab Alharbi, Mohammed AlSwayyed, Fawaz AlAsmari, Mohammed Alasmari, Abdulrahman Alshammari, Omer I. Fantoukh, Mohammed M. Alanazi
Summary: The study demonstrated that diosmin is effective in preventing Doxorubicin-induced nephrotoxicity by improving antioxidant mechanisms, reducing inflammation and apoptosis, and restoring kidney structure.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Sara A. A. Al-Kenany, Nada N. N. Al-Shawi
Summary: This study found that cafestol can alleviate the cardiotoxic effects induced by doxorubicin through the activation of the Nrf2 pathway. Cafestol improved doxorubicin-induced cardiac injury, reduced levels of cardiac enzymes in the blood, increased antioxidant levels, suppressed inflammation, inhibited cardiac apoptosis, and regulated the expression of related genes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ying Li, Jia Wang, Jiahui Jiang, Xiang Li, Ming Wang
Summary: The extract of Clerodendranthus spicatus (Thunb.) C. Y. Wu (CSTE) has protective effects on oxidative stress injury in HL-1 mouse cardiomyocytes induced by AAPH. It improves cell survival rates, reduces intracellular ROS and MDA levels, and decreases apoptosis by enhancing antioxidant enzyme activity and improving the endogenous antioxidant system.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Betul Danisman, Mustafa Ozkaraca, Behzad Mokhtare, Mecit Kantarci, Marios Spanakis, Dragana Nikitovic, Georgios Lazopoulos, Konstantinos Tsarouhas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This research evaluated the cardioprotective properties of chlorogenic acid (CGA) in doxorubicin (DOX)-induced cardiotoxicity and identified one of the possible mechanisms for its protective effects. The study found that CGA ameliorated oxidative stress and cardiomyocyte apoptosis by upregulating the Nrf2/HO-1-dependent pathway and downregulating dityrosine (DT) expression. These findings suggest that CGA may be cardioprotective, particularly in patients receiving DOX-based chemotherapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wen Xing, Chaoling Wen, Deguo Wang, Hui Shao, Chunhong Liu, Chunling He, Opeyemi Joshua Olatunji
Summary: This study evaluated the effect of costunolide on doxorubicin-induced cardiorenal toxicity in rats and found that costunolide can protect the heart and kidney from doxorubicin-induced injury by suppressing oxidative stress, inflammation, and apoptosis.
Article
Toxicology
Chen Zhang, Qinghua Dan, Song Lai, Yutong Zhang, Erer Gao, Haiyan Luo, Liping Yang, Xiaobo Gao, Cailing Lu
Summary: This study investigated the role of Rab10 in doxorubicin (DOX)-induced cardiotoxicity. The results showed that cardiac-specific overexpression of Rab10 alleviated cardiac dysfunction and mitochondrial damage caused by DOX treatment. Rab10 also inhibited apoptosis and oxidative stress in cardiomyocytes. Furthermore, Rab10 inhibited the cleavage of Mst1, a serine-threonine kinase, mediated by DOX treatment.
TOXICOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Nilsel Okudan, Muaz Belviranli, Tugba Sezer
Summary: The aim of this study was to investigate the potential neuroprotective efficacy of coenzyme Q10 (CoQ10) against doxorubicin (DOX)-induced behavioral disturbances in rats. The results showed that CoQ10 significantly attenuated DOX-induced behavioral alterations by improving acetylcholinesterase (AChE) activity in the brain tissue.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yan Gao, Jingyao Dong, Mengmeng Chen, Taiwei Wang, Zhaoyun Yang, Kang He, Yuewei Li, Kai Wang, Jian Jiang, Shuang Zhang
Summary: Low-dose radiation has a protective effect on brain injury in mice treated with doxorubicin. The mechanism is related to low-dose radiation alleviating mitochondrial dysfunction and oxidative stress, promoting the production of antioxidant damage proteins, and exerting an adaptive protective effect on cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Endocrinology & Metabolism
Tao Wei, Lei Wang, Jian Tang, Tolulope Joshua Ashaolu, Opeyemi Joshua Olatunji
Summary: This study investigated the protective effects of juglanin (JUG) against doxorubicin (DOX)-induced cognitive decline, oxidative stress, and inflammatory response in rats. The results showed that JUG significantly protected against DOX-induced cognitive impairment and depressive behaviors, while also ameliorating oxidative stress and inflammation.
METABOLIC BRAIN DISEASE
(2022)
Article
Neurosciences
Yasser A. Khadrawy, Eman N. Hosny, Haitham S. Mohammed
Summary: This study found that DOX inhibits the activities of acetylcholinesterase and monoamine oxidase, increases dopamine levels, and induces oxidative stress, while the protective effect of NC partially alleviates these adverse effects.
Article
Biochemistry & Molecular Biology
Xiaoli Cheng, Dan Liu, Haixu Song, Xiaoxiang Tian, Chenghui Yan, Yaling Han
Summary: The study demonstrated that overexpression of KNG1 exacerbates oxidative stress and mitochondrial damage in the heart induced by DOX, while knockdown of KNG1 has a protective effect. This may be exerted through the regulation of Nrf2, providing a potential therapeutic target for DOX-induced cardiotoxicity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Miriam Scicchitano, Cristina Carresi, Saverio Nucera, Stefano Ruga, Jessica Maiuolo, Roberta Macri, Federica Scarano, Francesca Bosco, Rocco Mollace, Antonio Cardamone, Anna Rita Coppoletta, Lorenza Guarnieri, Maria Caterina Zito, Irene Bava, Luca Cariati, Marta Greco, Daniela Patrizia Foti, Ernesto Palma, Micaela Gliozzi, Vincenzo Musolino, Vincenzo Mollace
Summary: Our study showed that Ica pretreatment of H9c2 cells before Doxo exposure improved cell viability, reduced ROS generation, prevented mitochondrial dysfunction and mPTP opening. Additionally, it was found that Ica inhibited Caveolin-1 expression levels and PDE5a activity, enhancing mitochondrial function and preventing apoptotic cell death while regulating autophagic processes.
Article
Biochemistry & Molecular Biology
Kenan Yildizhan, Zubeyir Huyut, Fikret Altindag
Summary: This study investigated the protective effect of selenium (Se) and the role of transient receptor potential melastatin-2 (TRPM2) channel activation in a model of doxorubicin (DOXR)-induced cardiotoxicity. The results showed that Se and/or ACA treatment could alleviate DOXR-induced cardiotoxicity and significantly reduce oxidative stress markers and TRPM2 channel levels in serum and cardiac tissues.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Surgery
Silvia Sanchez-Camara, Mari C. Asensio-Lopez, Mario Royo-Villanova, Fernando Soler, Ruben Jara-Rubio, Jose Francisco Garrido-Penalver, Eduardo Pinar, Alvaro Hernandez-Vicente, Jose Antonio Hurtado, Antonio Lax, Domingo A. Pascual-Figal
Summary: This study aims to determine the critical warm ischemia time based on in vivo biochemical changes. The findings suggest that there is a significant compromise in cellular function and viability 10 minutes after circulatory arrest, which is important for incorporating DCD into heart transplant programs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Juan F. Delgado-Jimenez, Javier Segovia-Cubero, Luis Almenar-Bonet, Javier de Juan-Baguda, Antonio Lara-Padron, Jose Manuel Garcia-Pinilla, Juan Luis Bonilla-Palomas, Silvia Lopez-Fernandez, Sonia Mirabet-Perez, Ines Gomez-Otero, Antonio Castro-Fernandez, Beatriz Diaz-Molina, Josebe Goirigolzarri-Artaza, Luis Miguel Rincon-Diaz, Domingo Andres Pascual-Figal, Manuel Anguita-Sanchez, Javier Muniz, Maria G. Crespo-Leiro
Summary: The prevalence of hyperkalaemia in outpatients with heart failure and reduced ejection fraction (HFrEF) was estimated and its impact on achieving optimal medical treatment was evaluated in this study. The results showed that hyperkalaemia is a common problem in the management of heart failure patients and limits the optimization of medical treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Miriam Diez-Diez, Marta Amoros-Perez, Jorge de la Barrera, Enrique Vazquez, Ana Quintas, Domingo A. Pascual-Figal, Ana Dopazo, Fatima Sanchez-Cabo, Monica E. Kleinman, Leslie B. Gordon, Valentin Fuster, Vicente Andres, Jose J. Fuster
Summary: Clonal hematopoiesis of indeterminate potential (CHIP), the presence of somatic mutations in cancer-related genes in blood cells without hematological cancer, is an important risk factor for age-related conditions, especially cardiovascular disease. It is unknown whether CHIP plays a role in premature aging syndromes. Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare genetic condition characterized by accelerated aging. This study investigated the prevalence of CHIP in HGPS patients and found that it is not frequent in HGPS, suggesting that it is unlikely to contribute to the pathophysiology of this accelerated aging syndrome.
Article
Cardiac & Cardiovascular Systems
Klaus K. Witte, Rolf Wachter, Michele Senni, Jan Belohlavek, Ewa Straburzynska-Migaj, Candida Fonseca, Eva Lonn, Adele Noe, Heike Schwende, Dmytro Butylin, YannTong Chiang, Domingo Pascual-Figal
Summary: The tolerability and dose up-titration patterns of sacubitril/valsartan in patients with heart failure with reduced ejection fraction (HFrEF) were comparable between patients with and without diabetes.
Article
Cardiac & Cardiovascular Systems
Phil McEwan, Cale Harrison, Rhona Binnie, Ruth D. Lewis, Alain Cohen-Solal, Lars H. Lund, Marcus Ohlsson, Stephan von Haehling, Josep Comin-Colet, Domingo A. Pascual-Figal, Sandra Wachter, Fabio Dorigotti, Antonio Ramirez de Arellano, Piotr Ponikowski, Ewa A. Jankowska
Summary: The study assessed the burden of disease and pharmacoeconomic implications of treating iron deficiency in patients with acute heart failure. The findings indicate that treatment with FCM can reduce hospitalizations and bed days, leading to savings in healthcare resources and improvement in quality of life for heart failure patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Domingo Pascual-Figal
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Domingo Pascual-Figal, J. Luis Zamorano, Mar Domingo, Herminio Morillas, Julio Nunez, Marta Cobo Marcos, Alejandro Riquelme-Perez, Albert Teis, Enrique Santas, Cesar Caro-Martinez, Jose Manuel Pinilla, Jose F. Rodriguez-Palomares, David Dobarro, M. Alejandra Restrepo-Cordoba, J. Ramon Gonzalez-Juanatey, Antoni Bayes Genis
Summary: The DAPA-MODA trial showed that dapagliflozin administration in stable chronic heart failure patients leads to global reverse remodelling of cardiac structure, including reductions in left atrial volume index, improvement in left ventricular geometry, and decreased concentrations of NT-proBNP.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Medicine, General & Internal
Jose Ramon Gonzalez-Juanatey, Josep Comin-Colet, Domingo Pascual Figal, Antoni Bayes-Genis, Jose Maria Cepeda, Jose M. Garcia-Pinilla, Antonio Garcia-Quintana, Luis Manzano, Jose Luis Zamorano
Summary: Heart failure requires a holistic approach that targets all neurohormonal systems, with vericiguat potentially playing a key role. The management of heart failure should be standardized at the local level, utilizing new technologies for remote monitoring and communication.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Medicine, Research & Experimental
Antonio Lax, Fernando Soler, Maria Josefa Fernandez del Palacio, Silvia Pascual-Oliver, Miriam Ruiz Ballester, Jose Javier Fuster, Domingo Pascual-Figal, Maria del Carmen Asensio-Lopez
Summary: This study investigated the role of the YY1/HDAC4/sST2 axis in doxorubicin-induced cardiotoxicity and found that blocking miR-106b can prevent this toxicity.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Medicine, General & Internal
Lourdes Vicent, Jesus Alvarez-Garcia, Rafael Vazquez-Garcia, Jose R. Gonzalez-Juanatey, Miguel Rivera, Javier Segovia, Domingo Pascual-Figal, Ramon Bover, Fernando Worner, Francisco Fernandez-Aviles, Albert Ariza-Sole, Manuel Martinez-Selles
Summary: The aim of this study was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. A total of 583 patients with left ventricular ejection fraction <40% were included in the study, among which 266 had CAD and 137 had idiopathic dilated cardiomyopathy (DCM). The study found that one-year mortality and readmissions were similar between patients with CAD and idiopathic DCM, but patients with idiopathic DCM were more likely to receive a heart transplant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Manuel Barreiro-Perez, Pablo Pastor Pueyo, Sergio Raposeiras-Roubin, Dolores Montero Corominas, Aitor Uribarri, Rocio Eiros Bachiller, Jose Rozado Castano, Luisa Garcia-Cuenllas Alvarez, Luis Serratosa Fernandez, Fernando Dominguez, Domingo Pascual Figal
Summary: This document, drafted by the Myocarditis Working Group of the Heart Failure Association of the Spanish Society of Cardiology in collaboration with the Spanish Agency for Medicines and Health Products (AEMPS), aims to summarize the knowledge acquired since the start of the SARS-CoV-2 pandemic regarding the diagnosis and treatment of myocarditis associated with SARS-CoV-2 infection or messenger RNA vaccine administration.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Manuel Veas Porlan, Antonio Tello-Montoliu, Cecilia Lopez-Garcia, Pablo Gil-Perez, Miriam Quintana-Giner, Raquel Lopez-Galvez, Jose Miguel Rivera-Caravaca, Francisco Marin, Domingo Pascual Figal
Summary: This study aimed to investigate the impact of chronic renal failure on the pharmacokinetics and pharmacodynamics of ticagrelor. It was found that patients with renal impairment showed higher levels of ticagrelor after 4 and 6 hours of use, but there were no significant differences in platelet inhibition.
IJC HEART & VASCULATURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Domingo Pascual-Figal, Jose Javier Fuster, Antoni Bayes-Genis
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Medicine, General & Internal
Carlos Escobar, Domingo Pascual-Figal, Luis Manzano, Julio Nunez, Miguel Camafort
Summary: Based on recent evidence, SGLT2 inhibitors, specifically dapagliflozin, are recommended as first-line therapy for managing heart failure patients, irrespective of ejection fraction, to reduce the burden of heart failure. Studies have shown that dapagliflozin significantly reduces the risk of cardiovascular death, all-cause death, total heart failure hospitalizations, and MACE in the entire spectrum of heart failure, with sustained benefits over time. Full implementation of dapagliflozin in clinical practice leads to a substantial reduction in hospitalizations for heart failure and death in real-life populations.
JOURNAL OF CLINICAL MEDICINE
(2023)