Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis

Heart Failure in Type 2 Diabetes Mellitus

(2019) Helena C. Kenny et al.   CIRCULATION RESEARCH

Tetramethylpyrazine partially relieves hypoxia-caused damage of cardiomyocytes H9c2 by downregulation of miR-449a

(2019) Xuesong Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Taiwanin C elicits apoptosis in arecoline and 4‐nitroquinoline‐1‐oxide‐induced oral squamous cell carcinoma cells and hinders proliferation via epidermal growth factor receptor/PI3K suppression

(2019) Cheng‐Yen Tsai et al.   ENVIRONMENTAL TOXICOLOGY

High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression

(2019) Kuen-Ming Wu et al.   Nutrition & Metabolism

Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts

(2018) Chih-Chung Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats

(2018) Jui-Ting Chiang et al.   ENVIRONMENTAL TOXICOLOGY

Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats

(2018) Kuan-Ho Lin et al.   Journal of Functional Foods

Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo

(2018) Hsiang-Ping Lee et al.   Journal of Functional Foods

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p-JNK mediated hypertrophy and enhancing P-IGF1R, p-akt, and p-Badser136 activity and by fortifying NRF2 antioxidation system

(2017) Marthandam Asokan Shibu et al.   ENVIRONMENTAL TOXICOLOGY

Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells

(2017) Jicheng Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

The effect of a number of H9C2 rat cardiomyocytes passage on repeatability of cytotoxicity study results

(2016) Piotr Witek et al.   CYTOTECHNOLOGY

Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts

(2016) Pei-Yu Chen et al.   ENVIRONMENTAL TOXICOLOGY

Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression

(2016) Chih-Chung Feng et al.   GROWTH FACTORS

Andrographis paniculata extract attenuates pathological cardiac hypertrophy and apoptosis in high-fat diet fed mice

(2016) You-Liang Hsieh et al.   JOURNAL OF ETHNOPHARMACOLOGY

Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis

(2016) Yu-Feng Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

(2016) Kiminori Sada et al.   PLoS One

2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells

(2015) Xuezhong Gong et al.   ARCHIVES OF TOXICOLOGY

Tetramethylpyrazine Ameliorated Hypoxia-Induced Myocardial Cell Apoptosis via HIF-1α/JNK/p38 and IGFBP3/BNIP3 Inhibition to Upregulate PI3K/Akt Survival Signaling

(2015) Kuan-Ho Lin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries

(2015) Rachel Wai-Sum Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide

(2015) Cheng-Yen Tsai et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle

(2014) Cristina Mammucari et al.   Autophagy

Molecular regulation of autophagy and apoptosis during ischemic and non-ischemic cardiomyopathy

(2014) James Shaw et al.   Autophagy

Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression

(2013) Zhao Chen et al.   CANCER LETTERS

Cocoa and Heart Health: A Historical Review of the Science

(2013) Deanna Pucciarelli   Nutrients

Characterization of cocoa liquors by GC-MS and LC-MS/MS: focus on alkylpyrazines and flavanols

(2012) Emanuele Magi et al.   JOURNAL OF MASS SPECTROMETRY

Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury

(2011) Lihong Fan et al.   JOURNAL OF VASCULAR SURGERY

The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro

(2010) Sarah J. Watkins et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia

(2010) Terry C.T. Or et al.   NEUROPHARMACOLOGY

BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

(2009) G Chinnadurai et al.   ONCOGENE

When apoptosis meets autophagy: deciding cell fate after trauma and sepsis

(2009) Ya-Ching Hsieh et al.   TRENDS IN MOLECULAR MEDICINE

Hypoxia-induced compensatory effect as related to Shh and HIF-1α in ischemia embryo rat heart

(2008) Jin-Ming Hwang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

The Cell Cycle Factor E2F-1 Activates Bnip3 and the Intrinsic Death Pathway in Ventricular Myocytes

(2007) Natalia Yurkova et al.   CIRCULATION RESEARCH

Differentially regulated functional gene clusters identified during ischemia and reperfusion in isolated cardiac myocytes using coverslip hypoxia

(2007) Kelly R. Pitts et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS