Article
Biochemistry & Molecular Biology
Shimaa S. Ramadan, Farah A. El Zaiat, Engy A. Habashy, Mostafa M. Montaser, Habeba E. Hassan, Shahinaz S. Tharwat, Manal El-khadragy, Ahmed E. Abdel Moneim, Gehad E. Elshopakey, Ahmed M. A. Akabawy
Summary: This study demonstrates that CoQ10, either alone or loaded with albumin nanoparticles, can protect against HgCl2-induced hepatorenal toxicity by reducing oxidative damage, inflammation, and apoptosis.
Article
Environmental Sciences
Yuan Liu, Yaxin Yao, Wenjing Tao, Feng Liu, Songbai Yang, Ayong Zhao, Dan Song, Xiangchen Li
Summary: This study investigated the role of CoQ10 in alleviating BPA-induced cell damage, demonstrating that CoQ10 effectively restored abnormalities caused by BPA, reduced apoptosis and ROS levels, improved mitochondrial membrane potential, and enhanced lysosome function and autophagy flux.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Salva Piscopo, Massimiliano Peana
Summary: Coenzyme Q(10) is an essential component of the electron transport chain and acts as an antioxidant. Deficiency of CoQ(10) can increase oxidative stress. Oral supplementation with high doses of CoQ(10) has shown beneficial effects on cardiovascular diseases and inflammation related to low CoQ(10) levels and high oxidative stress. It has also been suggested as a potential therapeutic agent for preventing and slowing the progression of metabolic syndrome, type 2 diabetes, neurodegenerative diseases, and male infertility. Further studies and well-designed clinical trials are needed to evaluate the benefits of CoQ(10) for these disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Francisco M. Gutierrez-Mariscal, Silvia de la Cruz-Ares, Jose D. Torres-Pena, Juan F. Alcala-Diaz, Elena M. Yubero-Serrano, Jose Lopez-Miranda
Summary: CoQ(10) plays a key role in the electron transport chain and acts as an antioxidant, deficiency of which can lead to chronic and age-related diseases, particularly in cardiovascular diseases. Clinical trials have analyzed the effect of CoQ(10) supplementation as a therapeutic approach to improve deficiencies in patients with cardiovascular diseases.
Article
Immunology
Heba A. Mohamed, Riham S. Said
Summary: The study demonstrates that CoQ10 can protect rats from lethal doses of radiation, promote intestinal epithelial regeneration, alleviate oxidative stress, counteract inflammatory response, and mitigate intestinal fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Xinyu Nie, Xinru Dong, Yuge Hu, Fangjun Xu, Cong Hu, Chang Shu
Summary: Female infertility and pregnancy maintenance are influenced by various factors, including oocyte quantity and quality, genital inflammation, endometriosis, and other diseases. Coenzyme Q10 (CoQ10) has been discovered as a promising adjunct in enhancing male reproductive performance due to its ability to reduce oxidative stress, enhance mitochondrial activity, regulate gene expression, and inhibit inflammatory responses. Additionally, CoQ10 has demonstrated properties that can regulate immune balance, act as an antioxidant, and promote glucose and lipid metabolism, making it a potential therapy for various female reproductive disorders.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Immunology
Yu Ji Jiang, Jian Jin, Qi Yan Nan, Jun Ding, Sheng Cui, Mei Ying Xuan, Mei Hua Piao, Shang Guo Piao, Hai Lan Zheng, Ji Zhe Jin, Byung Ha Chung, Chul Woo Yang, Can Li
Summary: This study suggests that CoQ10 attenuates renal fibrosis by interfering with necroinflammation via Wnt3 alpha/beta-catenin/GSK-3 beta signaling in UUO.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
David Mantle, Iain Parry Hargreaves
Summary: Mitochondrial dysfunction and oxidative stress play important roles in the pathogenesis of certain endocrine disorders. The vitamin-like substance coenzyme Q10 (CoQ10) may have potential roles in the pathogenesis and treatment of these disorders due to its key functions in mitochondrial function and antioxidant activity. This article reviews the role of CoQ10 deficiency and supplementation in disorders of the thyroid, pancreas, gonads, pituitary, and adrenals, with a particular focus on hyperthyroidism, type II diabetes, male infertility, and polycystic ovary syndrome.
Article
Biochemistry & Molecular Biology
Sabiha Fatima, Nida Suhail, May Alrashed, Samina Wasi, Feda S. Aljaser, Roua A. AlSubki, Ashwag S. Alsharidah, Naheed Banu
Summary: The combination of antioxidants EGCG and CoQ10 effectively alleviates cisplatin-induced liver toxicity by maintaining redox homeostasis and attenuating mitochondrial stress-related processes.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David Mantle, Nadia Turton, Iain P. Hargreaves
Summary: This article reviews the potential role of supplementary coenzyme Q10 (CoQ10) in mediating the pathogenic mechanism of Lyme disease. Lyme disease patients may experience fatigue and problems affecting the nervous system, cardiovascular system, and joints when antibiotic treatment is delayed or ineffective. It is believed that most of the tissue damage in Lyme disease is caused by the excessive inflammatory response of the host, involving a cycle of mitochondrial dysfunction, oxidative stress, and inflammation.
Review
Biochemistry & Molecular Biology
Juan M. Suarez-Rivero, Carmen J. Pastor-Maldonado, Suleva Povea-Cabello, Monica Alvarez-Cordoba, Irene Villalon-Garcia, Manuel Munuera-Cabeza, Alejandra Suarez-Carrillo, Marta Talaveron-Rey, Jose A. Sanchez-Alcazar
Summary: Coenzyme Q(10) is a key player in mitochondrial function with antioxidant properties, but its analogues with improved characteristics like water solubility and enhanced mitochondrial accumulation may potentially surpass its current role. Recent studies have shown that some of these analogues could outperform CoQ(10) in treating specific diseases.
Review
Biochemistry & Molecular Biology
David Mantle, Lauren Millichap, Jesus Castro-Marrero, Iain P. Hargreaves, Alessandra Napolitano
Summary: Coenzyme Q10 (CoQ10) plays vital roles in all cells, including mitochondria and extra-mitochondrial functions. CoQ10 deficiency is associated with a wide range of disorders and can be classified into primary and secondary types. Oral supplementation of CoQ10 may be effective in treating patients, but early recognition is crucial to prevent irreversible tissue damage. This article reviews clinical studies on the identification of CoQ10 deficiencies and the outcomes of CoQ10 supplementation, resolving the discrepancies in previous review articles. Potential issues and unresolved matters regarding CoQ10 supplementation in primary CoQ10 deficiency are also discussed.
Review
Biochemistry & Molecular Biology
David Mantle, Robert A. Heaton, Iain P. Hargreaves
Summary: Coenzyme Q10 plays crucial roles in the immune system as an electron carrier, antioxidant, and anti-inflammatory agent. It also functions within lysosomes, improving immune system function.
Article
Dermatology
Heba Ahmed Abdelkader, Laila Ahmed Rashed, Eman Assaad, Marwah Adly Saleh
Summary: CoQ10 levels were significantly lower in PV patients compared to controls, potentially related to autoimmune response; a significant positive correlation between serum and tissue CoQ10 levels was found in controls, but not in patients with PV.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gianmaria Salvio, Melissa Cutini, Alessandro Ciarloni, Lara Giovannini, Michele Perrone, Giancarlo Balercia
Summary: Infertility affects 15% of couples worldwide, with male factor being involved in 50% of cases. Research shows a strong association between oxidative stress and poor seminal fluid quality in male infertility, making antioxidants, such as CoQ10, an important part of treatment. Studies have shown beneficial effects of CoQ10 supplementation on semen parameters, but further research is needed to determine the optimal dosage and combination with other antioxidants.
Article
Chemistry, Multidisciplinary
Sheng-Huang Chang, Pei-Ying Pai, Chiung-Hung Hsu, Shibu Marthandam Asokan, Bruce Chi-Kang Tsai, Wen-Tsan Weng, Wei-Wen Kuo, Tzu-Ching Shih, Hui-Chuan Kao, William Shao-Tsu Chen, Chih-Yang Huang
Summary: This study aimed to investigate the toxicological effects of the combined use of amphetamine and heroin on the heart. The researchers examined the activity of cardiac-remodeling enzymes and the levels of plasma biomarkers and classic cardiac biomarkers. The results showed that the combined use of amphetamine and heroin led to changes in cardiac enzymes and increased levels of biomarkers, indicating potential cardiac injury.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Review
Sport Sciences
Luthfia Dewi, Yin-Chou Lin, Andrew Nicholls, Giancarlo Condello, Chih-Yang Huang, Chia-Hua Kuo
Summary: This study provides a quantitative estimate of the changes in Pax7(+) muscle stem cells and circulating CD34(+) bone marrow stem cells in humans following acute exercise. The results show that Pax7(+) cells in skeletal muscle increase significantly after resistance exercise, while circulating CD34(+) cells also increase after both resistance exercise and aerobic exercise but quickly return to baseline levels.
Article
Biotechnology & Applied Microbiology
Jing-Ying Lin, Bruce Chi-Kang Tsai, Hui-Chuan Kao, Chien-Yi Chiang, Yun-An Chen, William Shao-Tsu Chen, Tsung-Jung Ho, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study investigated the neuroprotective mechanisms of Lactobacillus reuteri GMNL-263 in streptozotocin-induced diabetic rats. The results showed that GMNL-263 attenuated diabetes-induced hippocampal damage by enhancing cell survival pathways and repressing inflammatory and apoptotic pathways. Histopathological analysis revealed that GMNL-263 prevented structural changes and reduced inflammation and apoptosis in the hippocampus. These findings suggest that GMNL-263 may have potential clinical application for the brain of diabetic individuals.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Toxicology
Indra Putra Taufani, Jiro Hasegawa Situmorang, Rifki Febriansah, Sri Tasminatun, Sunarno Sunarno, Liang-Yo Yang, Yi-Ting Chiang, Chih-Yang Huang
Summary: Ferroptosis is a form of cell death characterized by the accumulation of iron and lipid ROS. In this study, we investigated the role of GPX4 and Nrf2 in regulating ferroptosis. Our findings showed that inhibition of Nrf2 with ML385 enhanced the toxicity of RSL3 by increasing mitochondrial ROS levels and disrupting mitochondrial function. Additionally, the application of Mito TEMPOL prevented the upregulation of ROS and reduced the toxicity of RSL3, restoring the antioxidant capacity and mitochondrial function of the cells.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Pei-Rung Wu, Shang-Yin Chiang, Robert Midence, Wen-Chao Kao, Chun-Lun Lai, I-Cheng Cheng, Shen-Ju Chou, Chih-Cheng Chen, Chih-Yang Huang, Ruey-Hwa Chen
Summary: Patients with mutations in the WDR4 gene exhibit cerebellar atrophy and gait phenotypes, but the underlying mechanisms have not been explored. This study reveals a crucial role of Wdr4 in cerebellar development. Deficiency of Wdr4 in granule neuron progenitors (GNPs) leads to reduced foliation, smaller external and internal granular layers, compromised Purkinje neuron organization, and smaller molecular layer, resulting in locomotion defects.
CELL DEATH & DISEASE
(2023)
Article
Environmental Sciences
Cheng-You Lu, Chia-Hua Kuo, Wei-Wen Kuo, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Cheng-Yen Shih, Pi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho, Chih-Yang Huang
Summary: The study found that Ohwia caudata extract (OCE) inhibits inflammatory response and reduces proliferation and activation of fibroblast-like synoviocytes in rheumatoid arthritis (RA) through regulation of suppressors of cytokine signaling 3 (SOCS3) and the JAK2/STAT3 pathway. This suggests that OCE may be further investigated as a candidate anti-inflammatory and anti-arthritic agent.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mei-Chih Chen, Bing-Ze Yang, Wei-Wen Kuo, Shih-Hsin Wu, Tso-Fu Wang, Yu-Lan Yeh, Ming-Cheng Chen, Chih-Yang Huang
Summary: Resistance to chemotherapy is a major obstacle in cancer treatment. This study investigated the molecular mechanisms underlying drug resistance in colon cancer using oxaliplatin-resistant LOVOOR cells. The findings suggest that Aurora-A, a kinase involved in the G2/M phase, may contribute to the resistance of LOVOOR cells to oxaliplatin treatment by depressing p53 signaling. Targeting Aurora-A could be a potential solution for patients who have failed oxaliplatin treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Chih-Ming Su, Tung-Wei Hsu, Hsin-An Chen, Wan-Yu Wang, Chih-Yang Huang, Chih-Chiang Hung, Ming-Hsin Yeh, Yen-Hao Su, Ming-Te Huang, Po-Hsiang Liao
Summary: Metastasis in breast cancer is the main cause of death in clinical patients. Lower levels of Dicer protein in highly invasive breast cancer cells are usually associated with poor clinical outcomes. Our study reveals the regulatory mechanism of Dicer protein degradation through a process called chaperone-mediated autophagy (CMA), which promotes cancer metastasis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Chen-Chan Wei, Giancarlo Condello, Ai-Lun Yang, Szu-Hsien Yu, Yi-Hung Liao, Chung-Yu Chen, Chi-Chieh Hsu, Chi-Yang Huang, Chia-Hua Kuo
Summary: This study aimed to determine the effect of rectal defecation on endurance performance and blood supply to the prefrontal brain and sub-navel regions of elite triathletes. The results showed that defecation improved performance in cycling and increased blood availability to compensate for cerebral deoxygenation during exercise.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2023)
Article
Environmental Sciences
Dennis jine Yuan Hsieh, Md. Nazmul Islam, Wei-Wen Kuo, Marthandam Asokan Shibu, Chin-Hu Lai, Pi-Yu Lin, Shinn-Zong Lin, Michael Yu-Chih Chen, Chih-Yang Huang
Summary: This study aimed to investigate the effect of a combination of Artemisia argyi and Ohwia caudata leaf extracts with Isoliquiritigenin on the side effects of chemotherapy drugs. The results showed that this combination could improve cardiac damage and function, making it a potential herbal treatment for cardiac hypertrophy and inflammatory diseases.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Pei-Ying Lee, Bruce Chi-Kang Tsai, Maria Angelina Sitorus, Pi-Yu Lin, Shinn-Zong Lin, Cheng-Yen Shih, Shang-Yeh Lu, Yueh-Min Lin, Tsung-Jung Ho, Chih-Yang Huang
Summary: This study found that Ohwia caudata aqueous extract can effectively suppress doxorubicin-induced mitochondrial dysfunction, maintain the stability of stem cells, and reduce apoptosis rate. The findings provide new directions for the medical application of Ohwia caudata.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Yu-Jung Lin, Chih-Yang Huang, Kannan Ashok Kumar, Bruce Chi-Kang Tsai, Dennis Jine-Yuan Hsieh, Ping-Ling Chiu, Yung-Ming Chang, Tsung-Jung Ho, Wei-Wen Kuo, Da-Tong Ju
Summary: Hericium erinaceus mycelia extract can prevent the accumulation of Aβ and alpha-syn in A53T transgenic mice by regulating SIRT-1/ERK-1/2 mediated autophagy.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Oncology
Farheen Badrealam Khan, Parul Singh, Yahya F. Jamous, Syed Azmal Ali, Abdullah, Shahab Uddin, Qamar Zia, Manoj Kumar Jena, Mohsina Khan, Mohammad Owais, Chih Yang Huang, Venkatesh Chanukuppa, Chrismawan Ardianto, Long Chiau Ming, Waqas Alam, Haroon Khan, Mohammad Akli Ayoub
Summary: This article reviews the use of proteomics to study the molecular details of phytochemicals such as curcumin, genistein, and tanshinone IIA. These phytochemicals have various pharmacological properties that are extensively studied to understand their mechanisms of action. Proteomics technology has proved to be a reliable approach to unravel the molecular intricacies of phytochemicals.
Article
Medicine, Research & Experimental
Chikondi Jassi, Wei-Wen Kuo, Yu-Chun Chang, Tso-Fu Wang, Chi-Cheng Li, Tsung-Jung Ho, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Ming-Cheng Chen, Chih-Yang Huang
Summary: The combination of Aloin and CPT-11 has been found to have an enhanced anti-tumor effect in colorectal cancer. This combination reduces cell viability and induces apoptosis, while regulating the expression of miRNA-133b, IGF1R, and their downstream pathways. CPT-11 and Aloin show potential as combination treatment partners against colorectal cancer, with miRNA-133b possibly serving as a co-therapeutic target with IGF1R.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Yu-Jung Lin, Navaneethan Sundhar, Hema Sri Devi, Hsueh-Fa Pien, Shina Fong-Mei Wen, Jenn-Line Sheu, Bruce Chi-Kang Tsai, Chih-Yang Huang
Summary: A novel compound based on chromium (III) was synthesized and evaluated for its antiviral effectiveness against multiple variants of COVID-19. It demonstrated interference with the interaction between the spike protein and ACE2, reduced the expression of ACE2 and TMPRSS2, and inhibited the activity of 3CL and RdRp. This compound effectively inhibited viral infection in vitro and in vivo.