Clinical Evaluation of Amyloid-Related Imaging Abnormalities in Bapineuzumab Phase III Studies

Central Review of Amyloid-Related Imaging Abnormalities in Two Phase III Clinical Trials of Bapineuzumab in Mild-To-Moderate Alzheimer’s Disease Patients

(2017) Nzeera Ketter et al.   JOURNAL OF ALZHEIMERS DISEASE

Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials

(2016) Rik Vandenberghe et al.   Alzheimers Research & Therapy

Current thinking on the mechanistic basis of Alzheimer's and implications for drug development

(2015) C Ising et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pivotal trials for β-secretase inhibitors in Alzheimer's

(2015) Cormac Sheridan   NATURE BIOTECHNOLOGY

What lessons can be learned from failed Alzheimer’s disease trials?

(2015) Jeremy Toyn   Expert Review of Clinical Pharmacology

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities

(2013) Wagner Zago et al.   Alzheimers & Dementia

An MRI Rating Scale for Amyloid-Related Imaging Abnormalities with Edema or Effusion

(2013) F. Barkhof et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

MR Imaging Features of Amyloid-Related Imaging Abnormalities

(2013) J. Barakos et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

(2012) Reisa Sperling et al.   LANCET NEUROLOGY

Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer’s disease study cohorts from phase 3 trials of semagacestat and solanezumab

(2011) Christopher Carlson et al.   Alzheimers & Dementia

Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab

(2011) Susanne Ostrowitzki   ARCHIVES OF NEUROLOGY

A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease

(2010) Ronald S. Black et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Murine models of Alzheimer's disease and their use in developing immunotherapies

(2010) Thomas Wisniewski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The 11- -Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

(2010) J. Rosenstock et al.   DIABETES CARE

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

(2009) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY