Novel protein science enabled by total chemical synthesis

Post-Translational Backbone Engineering through Selenomethionine-Mediated Incorporation of Freidinger Lactams

(2018) Dillon T. Flood et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct synthesis of N-terminal thiazolidine-containing peptide thioesters from peptide hydrazides

(2018) Kohei Sato et al.   CHEMICAL COMMUNICATIONS

Features of Auxiliaries That Enable Native Chemical Ligation beyond Glycine and Cleavage via Radical Fragmentation

(2018) Simon F. Loibl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Racemic & quasi-racemic protein crystallography enabled by chemical protein synthesis

(2018) Stephen BH Kent   CURRENT OPINION IN CHEMICAL BIOLOGY

Segmental isotope labelling and solid-state NMR of a 12 × 59 kDa motor protein: identification of structural variability

(2018) Thomas Wiegand et al.   JOURNAL OF BIOMOLECULAR NMR

Native Chemical Ligation–Photodesulfurization in Flow

(2018) Timothy S. Chisholm et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue

(2018) Régis Boehringer et al.   Chemical Science

Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation

(2018) Joseph A. Harvey et al.   ACS Synthetic Biology

Total Chemical Synthesis of Modified Histones

(2018) Yun-Kun Qi et al.   Frontiers in Chemistry

Rapid and efficient protein synthesis through expansion of the native chemical ligation concept

(2018) Sameer S. Kulkarni et al.   Nature Reviews Chemistry

Reinvestigation of the biological activity of d-allo-ShK protein

(2017) Bobo Dang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities

(2017) Kateřina Macháčková et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V)

(2017) Adam M. Levinson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Selective Targeting of Hepatic Stellate Cells for Liver Fibrosis Treatment Using a d-Enantiomeric Peptide Ligand of Fn14 Identified by Mirror-Image mRNA Display

(2017) Luying Huang et al.   MOLECULAR PHARMACEUTICS

A fully automated flow-based approach for accelerated peptide synthesis

(2017) Alexander J Mijalis et al.   Nature Chemical Biology

A thermostable d-polymerase for mirror-image PCR

(2017) Andreas Pech et al.   NUCLEIC ACIDS RESEARCH

Peptide Weinreb amide derivatives as thioester precursors for native chemical ligation

(2017) Chang Rao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer

(2017) Gerbrand J. van der Heden van Noort et al.   ORGANIC LETTERS

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

(2017) Tomoya Kubota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures

(2017) Bobo Dang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Giant molecules: where chemistry, physics, and bio-science meet

(2017) Guang-Zhong Yin et al.   Science China-Chemistry

Topology: a unique dimension in protein engineering

(2017) Lianjie Xu et al.   Science China-Chemistry

Chemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid–hydroxylamine (KAHA) ligation

(2017) Florian Rohrbacher et al.   Chemical Science

Total chemical synthesis of a thermostable enzyme capable of polymerase chain reaction

(2017) Weiliang Xu et al.   Cell Discovery

A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo

(2016) Maruti Uppalapati et al.   ACS Chemical Biology

Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily

(2016) Ho Yeung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Total Chemical Synthesis of13C=18O Isotopomers of Human Insulin for Isotope-Edited FTIR

(2016) Balamurugan Dhayalan et al.   CHEMBIOCHEM

Screening of a virtual mirror-image library of natural products

(2016) Taro Noguchi et al.   CHEMICAL COMMUNICATIONS

Extending Halogen-based Medicinal Chemistry to Proteins

(2016) Krystel El Hage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomer/Oligomer Quasi-Racemic Protein Crystallography

(2016) Shuai Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of Single α-to-β Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization

(2016) Dale F. Kreitler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

Ubiquitin utilizes an acidic surface patch to alter chromatin structure

(2016) Galia T Debelouchina et al.   Nature Chemical Biology

A synthetic molecular system capable of mirror-image genetic replication and transcription

(2016) Zimou Wang et al.   Nature Chemistry

A radical approach to posttranslational mutagenesis

(2016) R. Hofmann et al.   SCIENCE

Chemical synthesis of erythropoietin glycoforms for insights into the relationship between glycosylation pattern and bioactivity

(2016) M. Murakami et al.   Science Advances

Blocking of the PD-1/PD-L1 Interaction by aD-Peptide Antagonist for Cancer Immunotherapy

(2015) Hao-Nan Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling the Assembly of Coiled-Coil Peptide Nanotubes

(2015) Franziska Thomas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

(2015) Mallikanti Seenaiah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The critical role of peptide chemistry in the life sciences

(2015) Stephen B.H. Kent   JOURNAL OF PEPTIDE SCIENCE

One-pot chemical synthesis of small ubiquitin-like modifier protein–peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates

(2015) Emmanuelle Boll et al.   Nature Protocols

A functional role of Rv1738 inMycobacterium tuberculosispersistence suggested by racemic protein crystallography

(2015) Richard D. Bunker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical ligation of the influenza M2 protein for solid-state NMR characterization of the cytoplasmic domain

(2015) Byungsu Kwon et al.   PROTEIN SCIENCE

Total Chemical Synthesis of Biologically Active Fluorescent Dye-Labeled Ts1 Toxin

(2014) Bobo Dang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formation and Rearrangement of Homoserine Depsipeptides and Depsiproteins in the α-Ketoacid-Hydroxylamine Ligation with 5-Oxaproline

(2014) Thomas G. Wucherpfennig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Editorial overview: Synthetic Biomolecules

(2014) Stephen BH Kent et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Statistical Analysis of Crystallization Database Links Protein Physico-Chemical Features with Crystallization Mechanisms

(2014) Diana Fusco et al.   PLoS One

A Supramolecular Peptide Synthesizer

(2013) Jordi Bertran-Vicente et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bringing the Science of Proteins into the Realm of Organic Chemistry: Total Chemical Synthesis of SEP (Synthetic Erythropoiesis Protein)

(2013) Stephen B. H. Kent   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure determination of α-helical membrane proteins by solution-state NMR: Emphasis on retinal proteins

(2013) Antoine Gautier   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography

(2013) Michal Avital-Shmilovici et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site

(2013) P. A. Sigala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine

(2013) B. Lewandowski et al.   SCIENCE

Thematic Minireview Series on Circular Proteins

(2012) David J. Craik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovering the Bacterial Circular Proteins: Bacteriocins, Cyanobactins, and Pilins

(2012) Manuel Montalbán-López et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Through the looking glass - a new world of proteins enabled by chemical synthesis

(2012) Stephen Kent et al.   JOURNAL OF PEPTIDE SCIENCE

Ionization state of the catalytic dyad Asp25/25′ in the HIV-1 protease: NMR studies of site-specifically 13C labelled HIV-1 protease prepared by total chemical synthesis

(2012) Vladimir Yu. Torbeev et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography

(2012) K. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Side-Chain Translocation MutagenesisviaIncorporation of Peptoid Residues

(2011) Byoung-Chul Lee et al.   ACS Chemical Biology

Design, Total Chemical Synthesis, and X-Ray Structure of a Protein Having a Novel Linear-Loop Polypeptide Chain Topology

(2011) Kalyaneswar Mandal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of a Biologically Active Triazole-Containing Analogue of Cystatin A Through Successive Peptidomimetic Alkyne-Azide Ligations

(2011) Ibai E. Valverde et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Chemical Synthesis of Biologically Active Vascular Endothelial Growth Factor

(2011) Kalyaneswar Mandal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single-Molecule Studies of HIV-1 Protease Catalysis Enabled by Chemical Protein Synthesis

(2011) Vladimir Yu. Torbeev et al.   ISRAEL JOURNAL OF CHEMISTRY

Protein conformational dynamics in the mechanism of HIV-1 protease catalysis

(2011) V. Y. Torbeev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Folding of [GluA4(OβThrB30)]Insulin (“Ester Insulin”): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin

(2010) Youhei Sohma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of a Potent D-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance

(2010) B. D. Welch et al.   JOURNAL OF VIROLOGY

D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mirror image phage display—a method to generate d-peptide ligands for use in diagnostic or therapeutical applications

(2009) Susanne Aileen Funke et al.   Molecular BioSystems

Asymmetric total syntheses of (+)- and (−)-versicolamide B and biosynthetic implications

(2009) Kenneth A. Miller et al.   Nature Chemistry

Synthesis, folding, and structure of the β-turn mimic modified B1 domain of streptococcal protein G

(2009) Benoit Odaert et al.   PROTEIN SCIENCE

Racemic crystallography-Easy crystals and easy structures: What's not to like?

(2009) Brian W. Matthews   PROTEIN SCIENCE

Polyubiquitin chains: functions, structures, and mechanisms

(2008) W. Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Mirror Image Forms of Snow Flea Antifreeze Protein Prepared by Total Chemical Synthesis Have Identical Antifreeze Activities

(2008) Brad L. Pentelute et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

X-ray Structure of Snow Flea Antifreeze Protein Determined by Racemic Crystallization of Synthetic Protein Enantiomers

(2008) Brad L. Pentelute et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY