In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Chemotherapy-Induced Peripheral Neuropathy

(2019) Timothy J Brown et al.   JAMA Oncology

Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice

(2019) Norimitsu Morioka et al.   BRAIN BEHAVIOR AND IMMUNITY

Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice

(2019) Guoxin Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Icariin, a flavonoid with anti-cancer effects, alleviated paclitaxel-induced neuropathic pain in a SIRT1-dependent manner

(2018) Yulong Gui et al.   Molecular Pain

Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives

(2018) Paramita Basu et al.   BIOMEDICINE & PHARMACOTHERAPY

Prevalence and Profile of High-Impact Chronic Pain in the United States

(2018) Mark H. Pitcher et al.   JOURNAL OF PAIN

Effects of baicalin on diabetic neuropathic pain involving transient receptor potential vanilloid 1 in the dorsal root ganglia of rats

(2018) Ping Li et al.   NEUROREPORT

Catechin attenuates diabetic autonomic neuropathy in streptozotocin induced diabetic rats

(2018) Veeranjaneyulu Addepalli et al.   BIOMEDICINE & PHARMACOTHERAPY

European marketable grain legume seeds: Further insight into phenolic compounds profiles

(2017) Sara C.Q. Magalhães et al.   FOOD CHEMISTRY

The effect of icariin on bone metabolism and its potential clinical application

(2017) Z. Wang et al.   OSTEOPOROSIS INTERNATIONAL

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

(2017) Hock Eng Khoo et al.   Food & Nutrition Research

Nrf2: a potential therapeutic target for diabetic neuropathy

(2017) Anil Kumar et al.   INFLAMMOPHARMACOLOGY

Effect of Kaempferol isolated from seeds of Eruca sativa on changes of pain sensitivity in Streptozotocin-induced diabetic neuropathy

(2017) Lalit Kishore et al.   INFLAMMOPHARMACOLOGY

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Effects of quercetin on chronic constriction nerve injury in an experimental rat model

(2016) Soner Çivi et al.   ACTA NEUROCHIRURGICA

Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells and subsequently blocking PKCε-dependent activation of TRPV1

(2016) Wei Gao et al.   ACTA PHARMACOLOGICA SINICA

6-Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the streptozotocin-induced diabetic neuropathic pain

(2016) Shehla Akbar et al.   BIOMEDICINE & PHARMACOTHERAPY

Quantitative assessment of chemotherapy-induced peripheral neurotoxicity using a point-of-care nerve conduction device

(2016) Ayumu Matsuoka et al.   CANCER SCIENCE

Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats

(2016) Ruifeng Tian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Central Neuropathic Pain Syndromes

(2016) James C. Watson et al.   MAYO CLINIC PROCEEDINGS

Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation

(2016) Prashanth Komirishetty et al.   NEUROCHEMICAL RESEARCH

Neuropathic pain

(2016) Nanna B. Finnerup et al.   PAIN

Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain

(2016) Azucena I. Carballo-Villalobos et al.   Biomed Research International

Chemotherapy-induced neuropathies-a growing problem for patients and health care providers

(2016) Marta Banach et al.   Brain and Behavior

Nociceptive spinal cord neurons of laminae I–III exhibit oxidative stress damage during diabetic neuropathy which is prevented by early antioxidant treatment with epigallocatechin-gallate (EGCG)

(2015) D. Raposo et al.   BRAIN RESEARCH BULLETIN

An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health

(2015) Khalid Zaheer et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Naringin Abrogates Cisplatin-Induced Cognitive Deficits and Cholinergic Dysfunction Through the Down-Regulation of AChE Expression and iNOS Signaling Pathways in Hippocampus of Aged Rats

(2015) Yassine Chtourou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy

(2015) Salim S. Al-Rejaie et al.   NEUROLOGICAL RESEARCH

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

(2015) Ergul Belge Kurutas   Nutrition Journal

Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system

(2015) Xin Zhao et al.   Scientific Reports

Novel Epigallocatechin-3-Gallate (EGCG) Derivative as a New Therapeutic Strategy for Reducing Neuropathic Pain after Chronic Constriction Nerve Injury in Mice

(2015) Xavier Xifró et al.   PLoS One

Matrix metalloproteinases: potential therapeutic target for diabetic neuropathic pain

(2014) Anurag Kuhad et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Taurine ameliorates neuropathy via regulating NF-κB and Nrf2/HO-1 signaling cascades in diabetic rats

(2014) Can Ali Agca et al.   FOOD AND CHEMICAL TOXICOLOGY

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

(2014) Dawn L. Hershman et al.   JOURNAL OF CLINICAL ONCOLOGY

Proanthocyanidins protect against early diabetic peripheral neuropathy by modulating endoplasmic reticulum stress

(2014) Ye Ding et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord

(2014) Ming Liu et al.   MEDIATORS OF INFLAMMATION

Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice

(2014) Tania E. Schwingel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling

(2014) Ying Lu et al.   PAIN

Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions

(2014) Asjad Visnagri et al.   PHARMACEUTICAL BIOLOGY

Effects of intrathecal and intracerebroventricular administration of luteolin in a rat neuropathic pain model

(2014) Koji Hara et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity

(2014) Manoj Aswar et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Spinal SIRT1 Activation Attenuates Neuropathic Pain in Mice

(2014) Haijun Shao et al.   PLoS One

Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2

(2013) Ludmila F.M.F. Cardozo et al.   BIOCHIMIE

Neuropathic pain in cancer

(2013) M.T. Fallon   BRITISH JOURNAL OF ANAESTHESIA

Mechanisms and Management of Diabetic Painful Distal Symmetrical Polyneuropathy

(2013) Solomon Tesfaye et al.   DIABETES CARE

Phytochemical Profiles of Black, Red, Brown, and White Rice from the Camargue Region of France

(2013) Gema Pereira-Caro et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Baicalin ameliorates neuropathic pain by suppressing HDAC1 expression in the spinal cord of spinal nerve ligation rats

(2013) Chen-Hwan Cherng et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

The Antioxidant Effects of the Flavonoids Rutin and Quercetin Inhibit Oxaliplatin-Induced Chronic Painful Peripheral Neuropathy

(2013) Maria Isabel Azevedo et al.   Molecular Pain

21st Century natural product research and drug development and traditional medicines

(2013) Linh T. Ngo et al.   NATURAL PRODUCT REPORTS

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

Clinical pattern and associations of oxaliplatin acute neurotoxicity

(2012) Andreas A. Argyriou et al.   CANCER

Treatment of neuropathic pain with plant medicines

(2012) Garima Garg et al.   Chinese Journal of Integrative Medicine

Epidemiology of Neuropathic Pain and Its Impact on Quality of Life

(2012) Blair H. Smith et al.   Current Pain and Headache Reports

Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats

(2012) Doo C. Choi et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy

(2012) Amit D. Kandhare et al.   FITOTERAPIA

Apigenin di-C-glycosides (ACG) content and composition in grains of bread wheat (Triticum aestivum) and related species

(2012) Grace Y. Wijaya et al.   JOURNAL OF CEREAL SCIENCE

Assessment of Oxidative Parameters in Rat Spinal Cord After Chronic Constriction of the Sciatic Nerve

(2012) Cristina S. B. Goecks et al.   NEUROCHEMICAL RESEARCH

Role of neuronal nitric oxide synthase in the antiallodynic effects of intrathecal EGCG in a neuropathic pain rat model

(2012) Jeong Il Choi et al.   NEUROSCIENCE LETTERS

Analgesic effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on spared nerve injury rat model of neuropathic pain

(2012) Mei Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Which Sources of Flavonoids: Complex Diets or Dietary Supplements?

(2012) Sarah Egert et al.   Advances in Nutrition

The burden associated with neuropathic pain in Western Europe

(2012) Paul C. Langley et al.   JOURNAL OF MEDICAL ECONOMICS

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

(2012) Paul J. Austin et al.   Jove-Journal of Visualized Experiments

Neurological diseases and pain

(2011) David Borsook   BRAIN

Structure-Activity Relationships of Flavonoids

(2011) Vaya Jacob et al.   CURRENT ORGANIC CHEMISTRY

Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K.

(2011) C. A. Abbott et al.   DIABETES CARE

Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats

(2011) Xin Kuang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative–nitrosative stress and p38 MAPK activation

(2011) Roman Stavniichuk et al.   EXPERIMENTAL NEUROLOGY

Oxaliplatin: a review of approved uses

(2011) Alexander Stein et al.   EXPERT OPINION ON PHARMACOTHERAPY

Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation

(2011) V. Bril et al.   NEUROLOGY

Plant derived alkaloid (−)-cassine induces anti-inflammatory and anti-hyperalgesics effects in both acute and chronic inflammatory and neuropathic pain models

(2011) Kathryn A.B.S. da Silva et al.   NEUROPHARMACOLOGY

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

Omega-3 Fatty Acids for Neuropathic Pain

(2010) Gordon D. Ko et al.   CLINICAL JOURNAL OF PAIN

Anti-allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38 and protein kinase C mediated modulation of Ca2+ channels

(2010) Tim Hagenacker et al.   EUROPEAN JOURNAL OF PAIN

The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model

(2010) Anna Elisa Valsecchi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Spinal Matrix Metalloproteinase-9 Contributes to Physical Dependence on Morphine in Mice

(2010) W.-T. Liu et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Class II Histone Deacetylases in the Spinal Cord Attenuates Inflammatory Hyperalgesia

(2010) Guang Bai et al.   Molecular Pain

Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain

(2010) Santina Chiechio et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Murine models of human neuropathic pain

(2009) Mariapia Colleoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Discovery of the nitric oxide signaling pathway and targets for drug development

(2009) Nathan et al.   Frontiers in Bioscience-Landmark

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

(2009) ATHANASIOS VALAVANIDIS et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Effects of Removal of Dietary Polyunsaturated Fatty Acids on Plasma Extravasation and Mechanical Allodynia in a Trigeminal Neuropathic Pain Model

(2009) Yasmina B Martin et al.   Molecular Pain

Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain

(2009) Long-Jun Wu et al.   Neurotherapeutics

The Prevalence of Neuropathic Pain: Clinical Evaluation Compared with Screening Tools in a Community Population

(2009) Barbara P. Yawn et al.   PAIN MEDICINE

Neuropathic Pain

(2009) Alec B. OʼConnor   PHARMACOECONOMICS

A review on oxaliplatin-induced peripheral nerve damage

(2008) Andreas A. Argyriou et al.   CANCER TREATMENT REVIEWS

Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity

(2008) Anna Elisa Valsecchi et al.   JOURNAL OF NEUROCHEMISTRY

Pioglitazone Attenuates Tactile Allodynia and Thermal Hyperalgesia in Mice Subjected to Peripheral Nerve Injury

(2008) Takehiko Maeda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice

(2008) K. Morita et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chemical Synthesis of Proanthocyanidins in Vitro and Their Reactions in Aging Wines

(2008) Fei He et al.   MOLECULES

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice

(2008) Mitsuo Tanabe et al.   NEUROPHARMACOLOGY

Pharmacological characterization and gene expression profiling of an L5/L6 spinal nerve ligation model for neuropathic pain in mice

(2008) T. Kiso et al.   NEUROSCIENCE

A2A adenosine receptor regulates glia proliferation and pain after peripheral nerve injury

(2008) Andreea S. Bura et al.   PAIN

Structure and function of enzymes involved in the biosynthesis of phenylpropanoids

(2008) J.-L. Ferrer et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones

(2008) Shiming Li et al.   Journal of Functional Foods