21st Century natural product research and drug development and traditional medicines

Substandard and falsified anti-tuberculosis drugs: a preliminary field analysis

(2013) R. Bate et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Bioinformatics challenges in de novo transcriptome assembly using short read sequences in the absence of a reference genome sequence

(2013) Elsa Góngora-Castillo et al.   NATURAL PRODUCT REPORTS

Natural product isolation – how to get from biological material to pure compounds

(2013) Franz Bucar et al.   NATURAL PRODUCT REPORTS

A global approach to analysis and interpretation of metabolic data for plant natural product discovery

(2013) Manhoi Hur et al.   NATURAL PRODUCT REPORTS

Using NMR to identify and characterize natural products

(2013) Rosemary C. Breton et al.   NATURAL PRODUCT REPORTS

Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays

(2013) Olivier Potterat et al.   NATURAL PRODUCT REPORTS

Approval of Novel TB Drug Celebrated--With Restraint

(2013) J. Cohen   SCIENCE

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance

(2012) A. H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of health biotechnology in developing countries: Can private-sector players be the prime movers?

(2012) Gulifeiya Abuduxike et al.   BIOTECHNOLOGY ADVANCES

Network-based drug discovery by integrating systems biology and computational technologies

(2012) E. L. Leung et al.   BRIEFINGS IN BIOINFORMATICS

Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

(2012) Moustapha Ouedraogo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Malaria plan under scrutiny

(2012) Amy Maxmen   NATURE

Malaria subsidy pilot soars, but some see turbulence ahead

(2012) Amy Maxmen   NATURE MEDICINE

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Quantitative Predictions of Binding Free Energy Changes in Drug-Resistant Influenza Neuraminidase

(2012) Daniel R. Ripoll et al.   PLoS Computational Biology

Network target for screening synergistic drug combinations with application to traditional Chinese medicine

(2011) Shao Li et al.   BMC Systems Biology

Discovering Natural Product Modulators to Overcome Multidrug Resistance in Cancer Chemotherapy

(2011) Chung-Pu Wu et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Advancing Access and Benefit Sharing for Genetic Resources and Traditional Knowledge

(2011) Charles R. McManis   EcoHealth

The Discovery of Medicines from Plants: A Current Biological Perspective1

(2011) James S. Miller   ECONOMIC BOTANY

Natural products as starting points for future anti-malarial therapies: going back to our roots?

(2011) Timothy NC Wells   MALARIA JOURNAL

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

The Use of Phylogeny to Interpret Cross-Cultural Patterns in Plant Use and Guide Medicinal Plant Discovery: An Example from Pterocarpus (Leguminosae)

(2011) C. Haris Saslis-Lagoudakis et al.   PLoS One

Informatics resources for tuberculosis – Towards drug discovery

(2011) Jagadish Chandrabose Sundaramurthi et al.   TUBERCULOSIS

Dynamical Basis for Drug Resistance of HIV-1 Protease

(2011) Yi Mao   BMC STRUCTURAL BIOLOGY

Network Systems Biology for Drug Discovery

(2010) D K Arrell et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Metabolomics of Medicinal Plants: The Importance of Multivariate Analysis of Analytical Chemistry Data

(2010) Taketo Okada et al.   Current Computer-Aided Drug Design

Tuberculosis: global approaches to a global disease

(2010) Denise E Kirschner et al.   CURRENT OPINION IN BIOTECHNOLOGY

Host–microbe interaction systems biology: lifecycle transcriptomics and comparative genomics

(2010) Daniel E Sturdevant et al.   Future Microbiology

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes

(2010) Vlado Dančík et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Global tuberculosis drug development pipeline: the need and the reality

(2010) Zhenkun Ma et al.   LANCET

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

(2010) Neel R Gandhi et al.   LANCET

New insights into the blood-stage transcriptome ofPlasmodium falciparumusing RNA-Seq

(2010) Thomas D. Otto et al.   MOLECULAR MICROBIOLOGY

Control of malaria

(2010) Santwana Kar et al.   NATURE REVIEWS DRUG DISCOVERY

Erratum: Artemisinin resistance: current status and scenarios for containment

(2010) Arjen M. Dondorp et al.   NATURE REVIEWS MICROBIOLOGY

Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua

(2010) P. R. Arsenault et al.   PLANT PHYSIOLOGY

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

(2010) I. A. Graham et al.   SCIENCE

Accomplishments in genome-scale in silico modeling for industrial and medical biotechnology

(2009) Caroline B. Milne et al.   Biotechnology Journal

Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing

(2009) Wei Wang et al.   BMC GENOMICS

Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?

(2009) Bhushan Patwardhan et al.   DRUG DISCOVERY TODAY

Antimicrobial natural products: an update on future antibioticdrug candidates

(2009) Muhammad Saleem et al.   NATURAL PRODUCT REPORTS

Synergy research: Approaching a new generation of phytopharmaceuticals

(2009) H. Wagner et al.   PHYTOMEDICINE

Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis

(2009) Dongming Ma et al.   PLANT AND CELL PHYSIOLOGY

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Bridging the gap between systems biology and medicine

(2009) Gilles Clermont et al.   Genome Medicine

Systems medicine: the future of medical genomics and healthcare

(2009) Charles Auffray et al.   Genome Medicine

Tuberculosis Drug Resistance Mutation Database

(2009) Andreas Sandgren et al.   PLOS MEDICINE

Metabolomics for phytomedicine research and drug development

(2008) Lie-Fen Shyur et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovering active compounds from mixture of natural products by data mining approach

(2008) Yi Wang et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

(2008) Jane M. Carlton et al.   NATURE

Systems biology of persistent infection: tuberculosis as a case study

(2008) Douglas Young et al.   NATURE REVIEWS MICROBIOLOGY

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH

Making artemisinin☆

(2008) Patrick S. Covello   PHYTOCHEMISTRY

Ethnopharmacy and natural product research—Multidisciplinary opportunities for research in the metabolomic age

(2008) Michael Heinrich   Phytochemistry Letters

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE

Applications of Metabolomics in Drug Discovery and Development

(2008) David S Wishart   Drugs in research & development

Cloning of artemisinin biosynthetic cDNAs and novel ESTs and quantification of low temperature-induced gene overexpression

(2008) QingPing Zeng et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography–mass spectrometry

(2007) Chenfei Ma et al.   JOURNAL OF CHROMATOGRAPHY A