Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments

Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain

(2019) Alexander Mueller et al.   PAIN

The expression of voltage-gated sodium channels in trigeminal nerve following chronic constriction injury in rats

(2019) MingXing Liu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

EAN guideline on trigeminal neuralgia

(2019) Lars Bendtsen et al.   EUROPEAN JOURNAL OF NEUROLOGY

Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics

(2019) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Altered brain network centrality in patients with trigeminal neuralgia: a resting-state fMRI study

(2019) Pei-Wen Zhu et al.   ACTA RADIOLOGICA

Frequency-specific alterations in cortical rhythms and functional connectivity in trigeminal neuralgia

(2019) Yanyang Zhang et al.   Brain Imaging and Behavior

SCN9A Epileptic Encephalopathy Mutations Display a Gain-of-function Phenotype and Distinct Sensitivity to Oxcarbazepine

(2019) Shuzhang Zhang et al.   Neuroscience Bulletin

A systematic review of rescue analgesic strategies in acute exacerbations of primary trigeminal neuralgia

(2019) D. Moore et al.   BRITISH JOURNAL OF ANAESTHESIA

A Comprehensive Review of Trigeminal Neuralgia

(2019) Mark R. Jones et al.   Current Pain and Headache Reports

Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis

(2019) Kimia Godazandeh et al.   Multiple Sclerosis and Related Disorders

Adverse effects of anti-epileptics in trigeminal neuralgiform pain

(2018) V. Tentolouris-Piperas et al.   ACTA NEUROLOGICA SCANDINAVICA

A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy

(2018) Talia A. Atkin et al.   EPILEPSIA

Assessment of efficacy and safety of eslicarbazepine acetate for the treatment of trigeminal neuralgia

(2018) A. Sanchez-Larsen et al.   EUROPEAN JOURNAL OF PAIN

CGRP as the target of new migraine therapies — successful translation from bench to clinic

(2018) Lars Edvinsson et al.   Nature Reviews Neurology

Role of KCNQ2 channels in orofacial cold sensitivity: KCNQ2 upregulation in trigeminal ganglion neurons after infraorbital nerve chronic constrictive injury

(2018) Jennifer Ling et al.   NEUROSCIENCE LETTERS

Antiepileptic drugs as analgesics/adjuvants in inflammatory pain: current preclinical evidence

(2018) Maja Tomić et al.   PHARMACOLOGY & THERAPEUTICS

A Systematic Review of the Management of Trigeminal Neuralgia in Patients with Multiple Sclerosis

(2018) Joanna M. Zakrzewska et al.   World Neurosurgery

Effects of a State- and Use-Dependent Nav1.7 Channel Blocker on Ambulatory Blood Pressure: A Randomized, Controlled Crossover Study

(2018) Regan Fong et al.   JOURNAL OF CLINICAL PHARMACOLOGY

OUP accepted manuscript

(2018)   PAIN MEDICINE

Different Pain States of Trigeminal Neuralgia Make Significant Changes in the Plasma Proteome and Some Biochemical Parameters: a Preliminary Cohort Study

(2018) Asghar Farajzadeh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: the trigeminal neuralgia experience

(2018) Joanna M. Zakrzewska et al.   Trials

Altered spontaneous brain activity in classical trigeminal neuralgia as determined by changes in regional homogeneity: a resting‐state functional MRI study

(2018) Xiang Chu‐Qing et al.   Pain Practice

Botulinum toxin-A for the treatment of neuralgia: a systematic review and meta-analysis

(2018) Fan Meng et al.   Journal of Pain Research

Phenotypic change in trigeminal ganglion neurons associated with satellite cell activation via extracellular signal-regulated kinase phosphorylation is involved in lingual neuropathic pain

(2017) Lou Mikuzuki et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Interaction between calcitonin gene-related peptide-immunoreactive neurons and satellite cells via P2Y12 R in the trigeminal ganglion is involved in neuropathic tongue pain in rats

(2017) Shiori Sugawara et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Pharmacological treatment of trigeminal neuralgia

(2017) Giulia Di Stefano et al.   Expert Review of Neurotherapeutics

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

(2017) Denis B. Tikhonov et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cortical Regulation of Nociception of the Trigeminal Nucleus Caudalis

(2017) Alberto Castro et al.   JOURNAL OF NEUROSCIENCE

Brainstem Pain-Control Circuitry Connectivity in Chronic Neuropathic Pain

(2017) Emily P. Mills et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen

(2017) P Ertzgaard et al.   JOURNAL OF REHABILITATION MEDICINE

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial

(2017) Joanna M Zakrzewska et al.   LANCET NEUROLOGY

Acetato de eslicarbazepina en dolor neuropático, cefaleas y neuralgias craneales: Evidencia y experiencia

(2017) A. Alcántara Montero et al.   NEUROLOGIA

Evaluating the impact of trigeminal neuralgia

(2017) Joanna M. Zakrzewska et al.   PAIN

Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia

(2017) Yuan Wang et al.   PAIN

Eslicarbazepine acetate as a therapeutic option in a patient with carbamazepine-induced rash and HLA-A*31:01

(2017) Lara Kay et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Pharmacological treatment of trigeminal neuralgia

(2017) Giulia Di Stefano et al.   Expert Review of Neurotherapeutics

Botulinum Toxin A Might Be an Alternative or Adjunct Therapy for the Treatment of Trigeminal and Postherpetic Neuralgia

(2017) Ya-Wei Chen et al.   Journal of Evidence-Based Dental Practice

Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment

(2017) Jan Keppel Hesselink et al.   Journal of Pain Research

Spatial–temporal signature of resting-state BOLD signals in classic trigeminal neuralgia

(2017) Yanping Wang et al.   Journal of Pain Research

Differential drug effects on spontaneous and evoked pain behavior in a model of trigeminal neuropathic pain

(2017) Kristof Deseure et al.   Journal of Pain Research

Clinical study of cerebrospinal fluid neuropeptides in patients with primary trigeminal neuralgia

(2016) Zhen-long Qin et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia

(2016) Brian S Tanaka et al.   MOLECULAR MEDICINE

Changes in the expression of voltage-gated sodium channels Nav1.3, Nav1.7, Nav1.8, and Nav1.9 in rat trigeminal ganglia following chronic constriction injury

(2016) Wenhua Xu et al.   NEUROREPORT

Antidepressants and gabapentinoids in neuropathic pain: Mechanistic insights

(2016) Mélanie Kremer et al.   NEUROSCIENCE

The Anti-Allodynic Gabapentinoids

(2016) Sascha R. A. Alles et al.   NEUROSCIENTIST

Regional Homogeneity

(2016) Lili Jiang et al.   NEUROSCIENTIST

Structural Magnetic Resonance Imaging Can Identify Trigeminal System Abnormalities in Classical Trigeminal Neuralgia

(2016) Danielle D. DeSouza et al.   Frontiers in Neuroanatomy

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

(2016) Jennifer Deuis et al.   Toxins

Central antinociceptive activity of peripherally applied botulinum toxin type A in lab rat model of trigeminal neuralgia

(2016) Chuanjie Wu et al.   SpringerPlus

KCNQ Channels in Nociceptive Cold-Sensing Trigeminal Ganglion Neurons as Therapeutic Targets for Treating Orofacial Cold Hyperalgesia

(2015) Alaa A Abd-Elsayed et al.   Molecular Pain

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamide

(2015) Simon Hebeisen et al.   NEUROPHARMACOLOGY

Update on neuropathic pain treatment for trigeminal neuralgia. The pharmacological and surgical options

(2015) Khalid Al-Quliti   Neurosciences

Corticotrigeminal Projections from the Insular Cortex to the Trigeminal Caudal Subnucleus Regulate Orofacial Pain after Nerve Injury via Extracellular Signal-Regulated Kinase Activation in Insular Cortex Neurons

(2015) Jian Wang et al.   Frontiers in Cellular Neuroscience

Botulinum Toxin as a Pain Killer: Players and Actions in Antinociception

(2015) Dong-Wan Kim et al.   Toxins

Advances in diagnosis and treatment of trigeminal neuralgia

(2015) Nicola Nicola Montano et al.   Therapeutics and Clinical Risk Management

Long-term safety and efficacy of eslicarbazepine acetate in patients with focal seizures: Results of the 1-year ESLIBASE retrospective study

(2014) V. Villanueva et al.   EPILEPSY RESEARCH

CGRP receptor blockade by MK-8825 alleviates allodynia in infraorbital nerve-ligated rats

(2014) B. Michot et al.   EUROPEAN JOURNAL OF PAIN

Trigeminal Neuralgia - A Prospective Systematic Study of Clinical Characteristics in 158 Patients

(2014) Stine Maarbjerg et al.   HEADACHE

Calcium Channel α2δ1Proteins Mediate Trigeminal Neuropathic Pain States Associated with Aberrant Excitatory Synaptogenesis

(2014) Kang-Wu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural history and outcome of 200 outpatients with classical trigeminal neuralgia treated with carbamazepine or oxcarbazepine in a tertiary centre for neuropathic pain

(2014) Giulia Di Stefano et al.   JOURNAL OF HEADACHE AND PAIN

Percutaneous Treatments for Trigeminal Neuralgia

(2014) Symeon Missios et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Microvascular Decompression for Trigeminal Neuralgia

(2014) Burak Sade et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Fully endoscopic microvascular decompression for trigeminal neuralgia: technique review and early outcomes

(2014) Leif-Erik Bohman et al.   Neurosurgical Focus

Magnetic resonance imaging contribution for diagnosing symptomatic neurovascular contact in classical trigeminal neuralgia: A blinded case-control study and meta-analysis

(2014) Giovanni Antonini et al.   PAIN

Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine, phenytoin and lamotrigine

(2013) Xin Qiao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

(2013) Ana Fortuna et al.   EPILEPSY RESEARCH

Gray matter volume reduction reflects chronic pain in trigeminal neuralgia

(2013) Mark Obermann et al.   NEUROIMAGE

Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients with trigeminal neuralgia

(2013) Joanna M Zakrzewska et al.   Trials

Medullary circuits for nociceptive modulation

(2012) Peggy Mason   CURRENT OPINION IN NEUROBIOLOGY

Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Integrated analysis of pooled data from double-blind phase III clinical studies

(2012) António Gil-Nagel et al.   EPILEPSIA

Pharmacokinetics and drug interactions of eslicarbazepine acetate

(2012) Meir Bialer et al.   EPILEPSIA

Why are antiepileptic drugs used for nonepileptic conditions?

(2012) Meir Bialer   EPILEPSIA

B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats

(2012) Caroline M. Kopruszinski et al.   LIFE SCIENCES

Reduction of TRPV1 expression in the trigeminal system by botulinum neurotoxin type-A

(2012) Toshihiko Shimizu et al.   NEUROBIOLOGY OF DISEASE

Resting state fMRI: A personal history

(2012) Bharat B. Biswal   NEUROIMAGE

Differential effects of calcitonin gene-related peptide receptor blockade by olcegepant on mechanical allodynia induced by ligation of the infraorbital nerve vs the sciatic nerve in the rat

(2012) Benoît Michot et al.   PAIN

A novel trigeminal neuropathic pain model: Compression of the trigeminal nerve root produces prolonged nociception in rats

(2012) Hye J. Jeon et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

Descending projections from the rostral ventromedial medulla (RVM) to trigeminal and spinal dorsal horns are morphologically and neurochemically distinct

(2011) Sue A. Aicher et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Inhibition of Nav 4 Peptide-Mediated Resurgent Sodium Currents in Nav1.7 Channels by Carbamazepine, Riluzole, and Anandamide

(2011) J. W. Theile et al.   MOLECULAR PHARMACOLOGY

Behavioral and immunohistochemical evidence for central antinociceptive activity of botulinum toxin A

(2011) I. Matak et al.   NEUROSCIENCE

Preoperative demonstration of the neurovascular compression characteristics with special emphasis on the degree of compression, using high-resolution magnetic resonance imaging: a prospective study, with comparison to surgical findings, in 100 consecutive patients who underwent microvascular decompression for trigeminal neuralgia

(2010) Paulo Roberto Lacerda Leal et al.   ACTA NEUROCHIRURGICA

Lidocaine, Carbamazepine, and Imipramine Have Partially Overlapping Binding Sites and Additive Inhibitory Effect on Neuronal Na+ Channels

(2010) Ya-Chin Yang et al.   ANESTHESIOLOGY

Flupirtine in Pain Management

(2010) Jacques Devulder   CNS DRUGS

Functional brain imaging of trigeminal neuralgia

(2010) Xavier Moissetl et al.   EUROPEAN JOURNAL OF PAIN

Central modulation of pain

(2010) Michael H. Ossipov et al.   JOURNAL OF CLINICAL INVESTIGATION

Nociceptors: the sensors of the pain pathway

(2010) Adrienne E. Dubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel   Subunits via Paradoxical Effects on Persistent Sodium Currents

(2010) M. Uebachs et al.   JOURNAL OF NEUROSCIENCE

Changes of Meningeal Excitability Mediated by Corticotrigeminal Networks: A Link for the Endogenous Modulation of Migraine Pain

(2010) R. Noseda et al.   JOURNAL OF NEUROSCIENCE

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders

(2010) Massimo Mantegazza et al.   LANCET NEUROLOGY

Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

(2010) G. M. Lipkind et al.   MOLECULAR PHARMACOLOGY

Treatment options in trigeminal neuralgia

(2010) Mark Obermann   Therapeutic Advances in Neurological Disorders

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

(2009) Tanya Z. Fischer et al.   ANNALS OF NEUROLOGY

Ultrastructure and immunohistochemistry of the trigeminal peripheral myelinated axons in patients with neuralgia

(2009) Slobodan Marinković et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+channel

(2009) Ya-Chin Yang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cell-Type-Dependent Molecular Composition of the Axon Initial Segment

(2009) A. Lorincz et al.   JOURNAL OF NEUROSCIENCE

Activation of TRPV1 Mediates Calcitonin Gene-Related Peptide Release, Which Excites Trigeminal Sensory Neurons and Is Attenuated by a Retargeted Botulinum Toxin with Anti-Nociceptive Potential

(2009) J. Meng et al.   JOURNAL OF NEUROSCIENCE

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Differential Involvement of Trigeminal Transition Zone and Laminated Subnucleus Caudalis in Orofacial Deep and Cutaneous Hyperalgesia: the Effects of Interleukin-10 and Glial Inhibitors

(2009) Kohei Shimizu et al.   Molecular Pain

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia

(2009) S.R.D.T. Siqueira et al.   NEUROSCIENCE

Gabapentin selectively reduces persistent sodium current in injured type-A dorsal root ganglion neurons

(2009) Rui-Hua Yang et al.   PAIN

2. Cluster Headache

(2009) Maarten van Kleef et al.   Pain Practice

AAN-EFNS guidelines on trigeminal neuralgia management

(2008) G. Cruccu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats

(2008) Dong K. Ahn et al.   EUROPEAN JOURNAL OF PAIN

An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: Fractional ALFF

(2008) Qi-Hong Zou et al.   JOURNAL OF NEUROSCIENCE METHODS

What we can do and what we cannot do with fMRI

(2008) Nikos K. Logothetis   NATURE

Practice Parameter: The diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies

(2008) G. Gronseth et al.   NEUROLOGY

Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy

(2008) Katherine D. Holland et al.   NEUROSCIENCE LETTERS