Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β‐catenin signaling

Expression of Long non-coding RNA ENSG00000226738 (LncKLHDC7B) is enriched in the immunomodulatory triple negative breast cancer subtype and its alteration promotes cell migration, invasion, and resistance to cell death

(2019) Fredy Omar Beltrán-Anaya et al.   Molecular Oncology

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

Long non-coding RNA LINC00662 promotes proliferation and migration in oral squamous cell carcinoma

(2019) Debin Xu et al.   OncoTargets and Therapy

Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression

(2019) Dengke Bao et al.   ONCOGENE

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response

(2019) Camilla Salvagno et al.   NATURE CELL BIOLOGY

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

(2019) Luca Cassetta et al.   CANCER CELL

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

(2019) Wenting Liao et al.   CANCER CELL

Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening

(2019) Roberta Esposito et al.   CANCER CELL

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes

(2019) Ruidong Xue et al.   CANCER CELL

TNF-α derived from M2 tumor-associated macrophages promotes epithelial-mesenchymal transition and cancer stemness through the Wnt/β-catenin pathway in SMMC-7721 hepatocellular carcinoma cells

(2019) Yongxu Chen et al.   EXPERIMENTAL CELL RESEARCH

FAK and β‐Catenin Cooperate to Induce Hepatocellular Carcinoma

(2019) Shang Na et al.   HEPATOLOGY

HDAC6 Suppresses Let‐7i‐5p to Elicit TSP1/CD47‐mediated Anti‐tumorigenesis and Phagocytosis of Hepatocellular Carcinoma

(2019) Hee Doo Yang et al.   HEPATOLOGY

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

Cellular functions of long noncoding RNAs

(2019) Run-Wen Yao et al.   NATURE CELL BIOLOGY

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

(2019) Mark Esposito et al.   NATURE CELL BIOLOGY

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

(2019) Wenjing Su et al.   CANCER CELL

Notch signaling via Wnt regulates the proliferation of alternative, CCR2-independent tumor-associated macrophages in hepatocellular carcinoma

(2019) Yu-Chen Ye et al.   CANCER RESEARCH

High expression of long intergenic non-coding RNA LINC00662 contributes to malignant growth of acute myeloid leukemia cells by upregulating ROCK1 via sponging microRNA-340-5p

(2019) Yuan Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

(2019) Chen Lu et al.   Molecular Cancer

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

(2018) Ashton C. Berger et al.   CANCER CELL

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

(2018) Zehua Wang et al.   CANCER CELL

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

(2018) Debanjan Dhar et al.   CANCER CELL

SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways

(2018) Yan-Li Zhang et al.   CANCER RESEARCH

Functional Classification and Experimental Dissection of Long Noncoding RNAs

(2018) Florian Kopp et al.   CELL

Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH

(2018) Sheel Shah et al.   CELL

Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment

(2018) Jingying Zhang et al.   HEPATOLOGY

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

(2018) Wang Lai Hu et al.   NATURE CELL BIOLOGY

Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors

(2018) Yang Yang et al.   Cell Death & Disease

circFGFR4 Promotes Differentiation of Myoblasts via Binding miR-107 to Relieve Its Inhibition of Wnt3a

(2018) Hui Li et al.   Molecular Therapy-Nucleic Acids

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CCL15 recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma

(2018) Long-Zi Liu et al.   HEPATOLOGY

Long non-coding RNA Linc00662 promotes cell invasion and contributes to cancer stem cell-like phenotypes in lung cancer cells

(2018) Wenjing Gong et al.   JOURNAL OF BIOCHEMISTRY

NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death

(2018) Di Huang et al.   NATURE IMMUNOLOGY

LINC00662 promotes gastric cancer cell growth by modulating the Hippo-YAP1 pathway

(2018) Zhen Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intricate crosstalk between MYC and non-coding RNAs regulates hallmarks of cancer

(2018) Lotteke J. Y. M. Swier et al.   Molecular Oncology

Interplay between small and long non-coding RNAs in cutaneous melanoma: a complex jigsaw puzzle with missing pieces

(2018) Mattia Riefolo et al.   Molecular Oncology

Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling

(2018) Nicoletta I. Petridou et al.   NATURE CELL BIOLOGY

Wnt/ β -Catenin–Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis

(2017) Ye Feng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling

(2017) Jia-Kuan Li et al.   Molecular Cancer

The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1

(2017) Ji-hang Yuan et al.   NATURE CELL BIOLOGY

Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activatingGPC3

(2016) Xiao-ting Zhu et al.   FEBS Journal

SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism

(2016) Lise Lotte Christensen et al.   Molecular Oncology

Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a

(2016) F Liu et al.   ONCOGENE

Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers

(2015) Xiaohui Yan et al.   CANCER CELL

A Dynamic Search Process Underlies MicroRNA Targeting

(2015) Stanley D. Chandradoss et al.   CELL

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

(2014) Ji-hang Yuan et al.   CANCER CELL

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2

(2014) Fang Wang et al.   HEPATOLOGY

Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma

(2012) Ling Zhang et al.   CARCINOGENESIS

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma

(2011) Ji-hang Yuan et al.   HEPATOLOGY

The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

(2008) Désirée Bonci et al.   NATURE MEDICINE