Review
Biochemistry & Molecular Biology
Jacek Rysz, Tomasz Konecki, Beata Franczyk, Janusz Lawinski, Anna Gluba-Brzozka
Summary: Renal cell carcinoma is a common cancer with increasing incidence and mortality worldwide. LncRNAs have shown promising potential in predicting the course and risk of metastasis in RCC. This review focuses on various LncRNAs and their roles in RCC, including their involvement in tumorigenesis, tumor promotion, tumor suppression, and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chen Yang, Yiwen Zang, Siqi Wu, Quan Zhou, Yuxi Ou, Qiang Ding, Hao Wang, Zuquan Xiong
Summary: This study demonstrates that the circFTO/miR-514b-3p/DUSP4 axis plays an important role in the development of ccRCC and may serve as a potential biomarker and therapeutic target.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Zhenpeng Zhu, Cuijian Zhang, Jinqin Qian, Ninghan Feng, Weijie Zhu, Yang Wang, Yanqing Gong, Xuesong Li, Jian Lin, Liqun Zhou
Summary: Our study identified ferroptosis-related lncRNAs and established a prognostic signature for predicting patient survival in ccRCC. Molecular subtyping and immune infiltration differences between clusters contributed to individualizing treatment approaches.
CANCER CELL INTERNATIONAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuanshen Zhao, Guiqin Liu, Qiuchang Sun, Guangtao Zhai, Guangyu Wu, Zhi-Cheng Li
Summary: A radiomics model using preoperative multiphasic CT was developed to predict distant metastasis after surgical resection in patients with localized ccRCC, and key biological pathways underlying the predictive radiomics features were identified. The 9-feature-based radiomics metastasis score performed well in predicting distant metastasis in the validation set, independently of clinical factors. Key biological pathways related to cancer progression and metastasis were found to be driving the predictive radiomics phenotypes.
EUROPEAN RADIOLOGY
(2021)
Article
Immunology
Yulin Deng, Kai Guo, Zhenfeng Tang, Yuanfa Feng, Shanghua Cai, Jianheng Ye, Yuanxue Xi, Jinchuang Li, Ren Liu, Chao Cai, Zeheng Tan, Yixun Zhang, Zhaodong Han, Guohua Zeng, Weide Zhong
Summary: In this study, we established a prognostic model for ccRCC using TIL-related lncRNAs. These lncRNAs were associated with T-cell activities and may serve as biomarkers of disease prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Ma, Manli Zhong, Xiaowu Liu
Summary: In this study, 297 glycolysis-associated lncRNAs were identified in ccRCC, with 7 of them found to have prognostic value. The results suggested a close association between the 7-lncRNA signature and glycolysis-related biological processes and pathways in ccRCC.
BIOSCIENCE REPORTS
(2021)
Article
Genetics & Heredity
Jinxing Lv, Qinghui Xu, Guoqing Wu, Jian Hou, Guang Yang, Cheng Tang, Genyi Qu, Yong Xu
Summary: A novel marker based on long non-coding RNA associated with necroptosis was developed to predict the prognosis of clear cell renal cell carcinoma (ccRCC) patients. The marker had higher predictive ability for prognosis compared to clinicopathological features and could serve as an independent predictor for ccRCC patients.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Jiayu Guo, Shuai Ke, Qi Chen, Jiangqiao Zhou, Jia Guo, Tao Qiu
Summary: NCOA7 is downregulated in various cancers, but its expression and prognostic significance in clear cell renal cell carcinoma (ccRCC) are unknown. In this study, NCOA7 expression in ccRCC tissues was analyzed, and its inhibitory role in ccRCC progression was demonstrated. Mechanistically, NCOA7 inhibited the MAPK/ERK pathway to regulate EMT and apoptosis, thus inhibiting ccRCC progression. These findings suggest that NCOA7 could serve as a prognostic marker and therapeutic target for ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gaoteng Lin, Huadong Wang, Yuqi Wu, Keruo Wang, Gang Li
Summary: In this study, 21 hub m6A-lncRNAs associated with tumor metastasis in KIRC were identified, and a ceRNA network was constructed. Two m6A-lncRNAs were found to be independent prognostic risk factors. The m6AlRsPI model based on these two m6A-lncRNAs showed promising predictive ability for survival in KIRC patients. Additionally, enrichment analysis revealed potential modulated processes in KIRC related to RNA splicing and regulation of mRNA surveillance pathway.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Qi Wang, Jiaju Xu, Zhiyong Xiong, Tianbo Xu, Jingchong Liu, Yuenan Liu, Jiaping Chen, Jian Shi, Yi Shou, Changjie Yue, Di Liu, Huageng Liang, Hongmei Yang, Xiong Yang, Xiaoping Zhang
Summary: This research identified that several CENP family members, especially CENPA, are highly expressed in ccRCC tissues and can serve as biomarkers for the disease. Overexpression of CENPA was found to promote ccRCC proliferation and metastasis by accelerating the cell cycle and activating the Wnt/beta-catenin signaling pathway. Targeting CENPA with selective drugs may be a promising direction for cancer treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Ryohei Kufukihara, Nobuyuki Tanaka, Kimiharu Takamatsu, Naoya Niwa, Keishiro Fukumoto, Yota Yasumizu, Toshikazu Takeda, Kazuhiro Matsumoto, Shinya Morita, Takeo Kosaka, Eriko Aimono, Hiroshi Nishihara, Ryuichi Mizuno, Mototsugu Oya
Summary: This study used HCR technology to visualize and evaluate ccRCC-associated lncRNA at both tissue and subcellular levels, identifying three lncRNAs associated with ccRCC prognosis. A new lncRNA risk group for ccRCC prognosis was established by combining the expression levels of these three lncRNAs, and intracellular colocalization of lncRNA signals was revealed. These findings provide important insights into lncRNAs as noncoding targets for cancer diagnosis and treatment.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Xiaoyu Chao, Pei Wang, Xiaoyu Ma, Zhenfen Li, Yubing Xia, Ying Guo, Linna Ge, Linzhu Tian, Hong Zheng, Yaowu Du, Jitian Li, Zhanjie Zuo, Longxiang Xie, Xiangqian Guo
Summary: This study identified various lncRNAs with different functions in ccRCC and they hold promise to be diagnostic, prognostic, and predictive biomarkers.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Biotechnology & Applied Microbiology
Keyi Wang, Yongzhe Gu, Jinliang Ni, Houliang Zhang, Yidi Wang, Yifan Zhang, Xianchao Sun, Tianyuan Xu, Weipu Mao, Bo Peng
Summary: This study reveals that decreased expression of ZNF268 is associated with tumor progression and poor prognosis in ccRCC. Overexpression of ZNF268 inhibits tumor cell proliferation, migration, and invasion, and promotes apoptosis. Moreover, ZNF268 expression is positively correlated with immune cell infiltration in the tumor. The study also suggests a potential regulatory axis of AC093157.1/miR-27a-3p in modulating ZNF268 function in ccRCC.
Article
Biochemistry & Molecular Biology
Bosen You, Yin Sun, Jie Luo, Keliang Wang, Qing Liu, Ruizhe Fang, Bingmei Liu, Fuju Chou, Ronghao Wang, Jialin Meng, Chi-Ping Huang, Shuyuan Yeh, Chawnshang Chang, Wanhai Xu
Summary: The study suggests that androgen receptor (AR) promotes vasculogenic mimicry (VM) formation in ccRCC cells by regulating lncRNA-TANAR/TWIST1 signals, potentially impacting metastasis. This discovery provides a clue for the development of a novel anti-angiogenesis therapy to better suppress ccRCC progression.
Article
Genetics & Heredity
Ming Zhong, Xiaohua Wang, Enyi Zhu, Lian Gong, Lingyan Fei, Liang Zhao, Keping Wu, Chun Tang, Lizhen Zhang, Zhongli Wang, Zhihua Zheng
Summary: This study systematically investigated the role of pyroptosis in clear cell renal cell carcinoma (ccRCC) and identified different subtypes with varied clinical outcomes, immune signatures, and responses to immunotherapy. Activation of pyroptosis was found to promote tumor progression by facilitating immune cell infiltration. A high pyroptosis-score was associated with an unfavorable immune environment and worse prognosis. The study also constructed a prognostic model based on pyroptosis-related long noncoding RNAs (PRlncRNAs) and explored the relationship between high- and low-risk groups with tumor microenvironment, immune infiltration, and drug therapy.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yi Bao, Fu Yang, Bing Liu, Tangliang Zhao, Zhipeng Xu, Ying Xiong, Shuhan Sun, Le Qu, Linhui Wang
BRITISH JOURNAL OF CANCER
(2018)
Article
Cell Biology
Anbang Wang, Yi Bao, Zhenjie Wu, Tangliang Zhao, Dong Wang, Jiazi Shi, Bing Liu, Shuhan Sun, Fu Yang, Linhui Wang, Le Qu
CELL DEATH & DISEASE
(2019)
Article
Cell Biology
Yinhui Li, Guiling Yan, Jie Zhang, Wei Chen, Tao Ding, Yupeng Yin, Minghan Liu, Yiqing Zhu, Shuhan Sun, Ji Hang Yuan, Zhiyong Guo
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Oncology
Jie Li, Ming-han Li, Tian-tian Wang, Xiao-ning Liu, Xiao-ting Zhu, Yun-zhang Dai, Ke-chao Zhai, Yong-da Liu, Jia-li Lin, Rui-liang Ge, Shu-han Sun, Fang Wang, Ji-hang Yuan
Summary: The study identified SLC38A4 as a novel oncofetal event and tumor suppressor in HCC, with low expression associated with poor prognosis. HMGCS2 was identified as a critical downstream target of SLC38A4, reversing the oncogenic effects of SLC38A4 depletion in HCC.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Gang Wei, Honglin Sun, Kai Dong, Libing Hu, Qi Wang, Qian Zhuang, Yan Zhu, Xianjing Zhang, Yaodi Shao, Huiru Tang, Zhenfei Li, Suzhen Chen, Junxi Lu, Yibing Wang, Xinxin Gan, Tao P. Zhong, Dingkun Gui, Xiaoyong Hu, Linhui Wang, Junli Liu
Summary: Clear cell renal cell carcinoma preferentially invades perinephric adipose tissue (PAT), with a bi-directional communication between ccRCC cells and PAT described in this study. The secretion of PTHrP by ccRCC cells promotes PAT browning, while PAT-mediated thermogenesis enhances ccRCC growth and metastasis. Tyrosine kinase inhibitors (TKIs) used in ccRCC treatment can exacerbate this vicious cycle, but pharmacological suppression of adipocyte browning can enhance the anti-tumor efficacy of TKI sunitinib.
Review
Urology & Nephrology
Zhenjie Wu, Qi Chen, Le Qu, Mingmin Li, Linhui Wang, Maria C. Mir, Umberto Carbonara, Savio D. Pandolfo, Peter C. Black, Asit K. Paul, Giuseppe Di Lorenzo, Francesco Porpiglia, Andrea Mari, Andrea Necchi, Morgan Roupret, Sarah P. Psutka, Riccardo Autorino
Summary: This study comprehensively investigated the incidence and profile of adverse events associated with immune checkpoint inhibitor therapy in urologic cancer patients. The findings revealed variations in the spectrum and incidence of adverse events across different cancer types, immune checkpoint inhibitor types, clinical settings, and therapy combinations.
Article
Biochemistry & Molecular Biology
Yinhui Li, Tao Ding, Haiyan Hu, Tingting Zhao, Chao Zhu, Jiarong Ding, Jihang Yuan, Zhiyong Guo
Summary: Through various experiments and analyses, this study revealed that lncRNA-ATB plays a crucial role in CaOx crystal-induced renal injury by influencing cell injury, apoptosis, proliferation inhibition, and EMT, ultimately contributing to the development of the disease.
MOLECULAR MEDICINE
(2021)
Article
Immunology
Aimin Jiang, Jialin Meng, Wenliang Gong, Zhonghua Zhang, Xinxin Gan, Jie Wang, Zhenjie Wu, Bing Liu, Le Qu, Linhui Wang
Summary: This study elucidated the clinical effect and tumor immune impact of SNRPA1 in ccRCC patients, as well as its role in drug sensitivity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Aimin Jiang, Ye Zhou, Wenliang Gong, Xin Pan, Xinxin Gan, Zhenjie Wu, Bing Liu, Le Qu, Linhui Wang
Summary: In this study, the role of CCNA2 at a pancancer level was comprehensively analyzed. CCNA2 was found to be differentially expressed in most cancer types and significantly influenced the prognosis, immune cell infiltration, and drug resistance.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Yun-Zhang Dai, Yong-da Liu, Jie Li, Mei-Ting Chen, Mei Huang, Fang Wang, Qing-Song Yang, Ji-Hang Yuan, Shu-Han Sun
Summary: This study identified the METTL16/RAB11B-AS1 regulatory axis in HCC, which represented novel targets for HCC prognosis and treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Surgery
Haifeng Wang, Wei Xue, Weigang Yan, Lei Yin, Baijun Dong, Biming He, Yongwei Yu, Wentao Shi, Zhien Zhou, Hengzhi Lin, Yi Zhou, Yanqing Wang, Zhenkai Shi, Shancheng Ren, Xu Gao, Linhui Wang, Chuanliang Xu
Summary: High-frequency irreversible electroporation (H-FIRE) is a promising treatment for localized prostate cancer. It can selectively destroy cancer cells while preserving surrounding nerves and blood vessels. The study showed that H-FIRE had a lower rate of clinically significant prostate cancer at 6 months compared to other energy platforms.
Article
Medicine, Research & Experimental
Le Qu, Hui Chen, Qi Chen, Silun Ge, Aimin Jiang, Nengwang Yu, Yulin Zhou, Michal Kunc, Ye Zhou, Xiang Feng, Wei Zhai, Zhenjie Wu, Miaoxia He, Yaoming Li, Rui Chen, Bo Han, Xing Zeng, Yao Fu, Changwei Ji, Xiang Fan, Guangyuan Zhang, Cheng Zhao, Taile Jing, Chenchen Feng, Hongwei Zhao, Di Sun, Liang Wang, Sheng Tai, Cheng Zhang, Shaohao Chen, Yixun Liu, Haifeng Wang, Jinli Gao, Yufeng Gu, He Miao, Tangliang Zhao, Xiaoming Yi, Chaopeng Tang, Dian Fu, Haowei He, Qiu Rao, Wenquan Zhou, Ning Xu, Gongxian Wang, Chaozhao Liang, Zhiyu Liu, Dan Xia, Xiongbing Zu, Ming Chen, Hongqian Guo, Weijun Qin, Zhe Wang, Wei Xue, Benkang Shi, Shaogang Wang, Junhua Zheng, Cheng Chen, Lukasz Zapala, Jingping Ge, Linhui Wang
Summary: Through whole-exome sequencing, it was found that metastases in nonmetastatic ccRCC patients mainly originated from venous tumor thrombus (VTT) rather than primary tumors. Pathological grading of VTT outperformed other indicators in risk assessment. A new prognostic tool, TT-GPS score, incorporating VTT grading, showed better discriminatory ability in predicting the survival of nonmetastatic ccRCC patients with VTT compared to previously reported models.
Article
Multidisciplinary Sciences
Yicun Wang, Jinhui Wu, Hui Chen, Yang Yang, Chengwu Xiao, Xiaoming Yi, Changjie Shi, Ke Zhong, Haowei He, Yaoming Li, Zhenjie Wu, Guangxin Zhou, Qiu Rao, Xiaoxia Wang, Xiaodie Zhou, Gwen Lomberk, Bing Liu, Jianning Zhao, Jingping Ge, Wenquan Zhou, Xiaoyuan Chu, Cheng Chen, Xuhui Zhou, Linhui Wang, Kunliang Guan, Le Qu
Summary: The study identified KLF11 as a negative regulator in sarcoma cancer stem cells, forming a negative feedback loop with YAP/TEAD. Epigenetic silencing of KLF11 in CSCs leads to sustained YAP activation, which is associated with poor prognosis and chemotherapy response in sarcoma patients. Pharmacological activation of KLF11 effectively restored chemotherapy response.