Phosphoproteomic analysis of STRIPAK mutants identifies a conserved serine phosphorylation site in PAK kinase CLA4 to be important in fungal sexual development and polarized growth

STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases

(2019) Ulrich Kück et al.   BIOLOGICAL CHEMISTRY

Cla4 PAK-like kinase is required for pathogenesis, asexual/sexual development and polarized growth in Bipolaris maydis

(2019) Yuki Kitade et al.   CURRENT GENETICS

A new identified suppressor of Cdc7p/SepH kinase, PomA, regulates fungal asexual reproduction via affecting phosphorylation of MAPK-HogA

(2019) Xiaogang Zhou et al.   PLoS Genetics

Combination of Proteogenomics with PeptideDe NovoSequencing Identifies New Genes and Hidden Posttranscriptional Modifications

(2019) B. Blank-Landeshammer et al.   mBio

A Hippo Pathway Related GCK Controls Both Sexual and Vegetative Developmental Processes in the FungusSordaria macrospora

(2018) Daria Radchenko et al.   GENETICS

A Hippo Pathway Related GCK Controls Both Sexual and Vegetative Developmental Processes in the FungusSordaria macrospora

(2018) Daria Radchenko et al.   GENETICS

NBR1 is involved in selective pexophagy in filamentous ascomycetes and can be functionally replaced by a tagged version of its human homolog

(2018) Antonia Werner et al.   Autophagy

A novel STRIPAK complex component mediates hyphal fusion and fruiting-body development in filamentous fungi

(2018) Eva Johanna Reschka et al.   MOLECULAR MICROBIOLOGY

MoMo: Discovery of statistically significant post-translational modification motifs

(2018) Alice Cheng et al.   BIOINFORMATICS

The transcription factor PRO44 and the histone chaperone ASF1 regulate distinct aspects of multicellular development in the filamentous fungus Sordaria macrospora

(2018) David Immanuel Schumacher et al.   BMC GENETICS

FPD: A comprehensive phosphorylation database in fungi

(2017) Youhuang Bai et al.   Fungal Biology

Structure, biochemistry, and biology of PAK kinases

(2017) Rakesh Kumar et al.   GENE

Functional Profiling of Transcription Factor Genes in Neurospora crassa

(2017) Alexander J. Carrillo et al.   G3-Genes Genomes Genetics

Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function

(2017) Kexin Gai et al.   PLoS Genetics

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

(2017) Sung Jun Bae et al.   eLife

The composition and function of the striatin-interacting phosphatases and kinases (STRIPAK) complex in fungi

(2016) Ulrich Kück et al.   FUNGAL GENETICS AND BIOLOGY

New insights from an old mutant: SPADIX4 governs fruiting body development but not hyphal fusion in Sordaria macrospora

(2016) Ines Teichert et al.   MOLECULAR GENETICS AND GENOMICS

Transcription factor PRO1 targets genes encoding conserved components of fungal developmental signaling pathways

(2016) Eva Katharina Steffens et al.   MOLECULAR MICROBIOLOGY

STRIPAK complexes in cell signaling and cancer

(2016) Z Shi et al.   ONCOGENE

The deadenylase components Not2p, Not3p, and Not5p promote mRNA decapping

(2016) Najwa Alhusaini et al.   RNA

Catalytic Subunit 1 of Protein Phosphatase 2A Is a Subunit of the STRIPAK Complex and Governs Fungal Sexual Development

(2016) Anna Beier et al.   mBio

Proteomic and Phosphoproteomic Insights into a Signaling Hub Role for Cdc14 in Asexual Development and Multiple Stress Responses in Beauveria bassiana

(2016) Zhi-Kang Wang et al.   PLoS One

Genome-wide analysis of the endoplasmic reticulum stress response during lignocellulase production in Neurospora crassa

(2015) Feiyu Fan et al.   Biotechnology for Biofuels

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

(2015) A. Pandolfi et al.   BLOOD

Current strategies and findings in clinically relevant post-translational modification-specific proteomics

(2015) Oliver Pagel et al.   Expert Review of Proteomics

Small GTPase Rac1 and its interaction partner Cla4 regulate polarized growth and pathogenicity in Verticillium dahliae

(2015) Hui Tian et al.   FUNGAL GENETICS AND BIOLOGY

Phosphoproteome Analysis Links Protein Phosphorylation to Cellular Remodeling and Metabolic Adaptation during Magnaporthe oryzae Appressorium Development

(2015) William L. Franck et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative proteomic study of Aspergillus Fumigatus secretome revealed deamidation of secretory enzymes

(2015) Sunil S. Adav et al.   Journal of Proteomics

Germinal Center Kinases SmKIN3 and SmKIN24 Are Associated with the Sordaria macrospora Striatin-Interacting Phosphatase and Kinase (STRIPAK) Complex

(2015) Stefan Frey et al.   PLoS One

Calcium/calmodulin-dependent kinases are involved in growth, thermotolerance, oxidative stress survival, and fertility in Neurospora crassa

(2014) Ravi Kumar et al.   ARCHIVES OF MICROBIOLOGY

A Fungal Sarcolemmal Membrane-Associated Protein (SLMAP) Homolog Plays a Fundamental Role in Development and Localizes to the Nuclear Envelope, Endoplasmic Reticulum, and Mitochondria

(2014) Steffen Nordzieke et al.   EUKARYOTIC CELL

The proteome and phosphoproteome of Neurospora crassa in response to cellulose, sucrose and carbon starvation

(2014) Yi Xiong et al.   FUNGAL GENETICS AND BIOLOGY

CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa

(2014) A. Lichius et al.   JOURNAL OF CELL SCIENCE

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

HAM-5 Functions As a MAP Kinase Scaffold during Cell Fusion in Neurospora crassa

(2014) Wilfried Jonkers et al.   PLoS Genetics

PRO40 Is a Scaffold Protein of the Cell Wall Integrity Pathway, Linking the MAP Kinase Module to the Upstream Activator Protein Kinase C

(2014) Ines Teichert et al.   PLoS Genetics

STRIPAK complexes: Structure, biological function, and involvement in human diseases

(2013) Juyeon Hwang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein kinase CK2 phosphorylates and activates p21-activated kinase 1

(2013) Yong Jae Shin et al.   MOLECULAR BIOLOGY OF THE CELL

LAMMER Kinase LkhA Plays Multiple Roles in the Vegetative Growth and Asexual and Sexual Development of Aspergillus nidulans

(2013) Eun-Hye Kang et al.   PLoS One

A Network of HMG-box Transcription Factors Regulates Sexual Cycle in the Fungus Podospora anserina

(2013) Jinane Ait Benkhali et al.   PLoS Genetics

A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells

(2012) Karl Staser et al.   EXPERIMENTAL HEMATOLOGY

The Neurospora crassa OS MAPK pathway-activated transcription factor ASL-1 contributes to circadian rhythms in pathway responsive clock-controlled genes

(2012) Teresa M. Lamb et al.   FUNGAL GENETICS AND BIOLOGY

TiSH — a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

(2012) Kasper Engholm-Keller et al.   Journal of Proteomics

A homologue of the human STRIPAK complex controls sexual development in fungi

(2012) Sandra Bloemendal et al.   MOLECULAR MICROBIOLOGY

Whole-Genome Sequencing of Sordaria macrospora Mutants Identifies Developmental Genes

(2012) Minou Nowrousian et al.   G3-Genes Genomes Genetics

Global Analysis of Serine-Threonine Protein Kinase Genes in Neurospora crassa

(2011) Gyungsoon Park et al.   EUKARYOTIC CELL

Identification and Characterization of Genes Required for Cell-to-Cell Fusion in Neurospora crassa

(2011) Ci Fu et al.   EUKARYOTIC CELL

Universal and Confident Phosphorylation Site Localization Using phosphoRS

(2011) Thomas Taus et al.   JOURNAL OF PROTEOME RESEARCH

Quality control of nano-LC-MS systems using stable isotope-coded peptides

(2011) Julia Maria Burkhart et al.   PROTEOMICS

Ste20-related kinases: effectors of signaling and morphogenesis in fungi

(2011) Kylie J. Boyce et al.   TRENDS IN MICROBIOLOGY

Functional Analysis of the Kinome of the Wheat Scab Fungus Fusarium graminearum

(2011) Chenfang Wang et al.   PLoS Pathogens

Profiling theAspergillus fumigatusProteome in Response to Caspofungin

(2010) Steven E. Cagas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Characterization ofMAT1-1-Specific Mating-Type Genes in the Homothallic Ascomycete Sordaria macrospora Provides New Insights into Essential and Nonessential Sexual Regulators

(2010) V. Klix et al.   EUKARYOTIC CELL

PAK1 as a therapeutic target

(2010) Julia V Kichina et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Undesirable Charge-Enhancement of Isobaric Tagged Phosphopeptides Leads to Reduced Identification Efficiency

(2010) Tine E. Thingholm et al.   JOURNAL OF PROTEOME RESEARCH

Why an A-Loop Phospho-Mimetic Fails to Activate PAK1: Understanding an Inaccessible Kinase State by Molecular Dynamics Simulations

(2010) Yuen-Wai Ng et al.   STRUCTURE

The Cdc42 Effectors Ste20, Cla4, and Skm1 Down-Regulate the Expression of Genes Involved in Sterol Uptake by a Mitogen-activated Protein Kinase-independent Pathway

(2009) Meng Lin et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of cardiac excitation and contraction by p21 activated kinase-1

(2009) Yunbo Ke et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Three  -Subunits of Heterotrimeric G Proteins and an Adenylyl Cyclase Have Distinct Roles in Fruiting Body Development in the Homothallic Fungus Sordaria macrospora

(2008) J. Kamerewerd et al.   GENETICS

The small GTPase Rac and the p21-activated kinase Cla4 in Claviceps purpurea: interaction and impact on polarity, development and pathogenicity

(2008) Yvonne Rolke et al.   MOLECULAR MICROBIOLOGY

Proteomic analyses ofFusarium graminearum grown under mycotoxin-inducing conditions

(2008) Rebecca D. Taylor et al.   PROTEOMICS