The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through inhibition of the PI3K/Akt/mTOR/NF-κB axis
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through inhibition of the PI3K/Akt/mTOR/NF-κB axis
Authors
Keywords
-
Journal
MOLECULAR BIOLOGY REPORTS
Volume 47, Issue 3, Pages 2217-2230
Publisher
Springer Science and Business Media LLC
Online
2020-02-22
DOI
10.1007/s11033-020-05327-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights
- (2019) Ammad Ahmad Farooqi et al. SEMINARS IN CANCER BIOLOGY
- Combinatorial strategy of epigenetic and hormonal therapies: A novel promising approach for treating advanced prostate cancer
- (2018) Tarek K. Motawi et al. LIFE SCIENCES
- Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma
- (2018) Mona A. Abdelmoneem et al. JOURNAL OF CONTROLLED RELEASE
- Comparative Bioavailability of Two Diosmin Formulations after Oral Administration to Healthy Volunteers
- (2018) Rosario Russo et al. MOLECULES
- Synergistic antiproliferative effects of curcumin and celecoxib in hepatocellular carcinoma HepG2 cells
- (2018) Fatma M. Abdallah et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review
- (2018) Pandurangan Ashokkumar et al. World Journal of Gastrointestinal Oncology
- Novel targeting approaches and signaling pathways of colorectal cancer: An insight
- (2018) Ankita Tiwari et al. WORLD JOURNAL OF GASTROENTEROLOGY
- The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression
- (2017) Martha L. Slattery et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The effect of vascular endothelial growth factor-1 expression on survival of advanced colorectal cancer patients
- (2017) Riyad Bendardaf et al. Libyan Journal of Medicine
- Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity
- (2017) Anna Lewinska et al. TOXICOLOGY LETTERS
- Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer
- (2017) Fei Yang et al. OncoTargets and Therapy
- Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines
- (2017) Pengliang Xin et al. Drug Design Development and Therapy
- Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer
- (2017) Dominika E. Butler et al. Oncotarget
- Interplay between apoptosis and autophagy in colorectal cancer
- (2017) Hao-Ran Qian et al. Oncotarget
- Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis
- (2016) Yvette J. Merga et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Diosmin induce apoptosis through modulation of STAT-3 signaling in 7,12 dimethylbenz(a)anthracene induced harmster buccal pouch carcinogenesis
- (2016) Muthusamy Rajasekar et al. BIOMEDICINE & PHARMACOTHERAPY
- Targeting PI3K Signaling in Cancer: A Cautionary Tale of Two AKTs
- (2016) Jérôme Fortin et al. CANCER CELL
- Cytotoxicity, Post-Treatment Recovery, and Selectivity Analysis of Naturally Occurring Podophyllotoxins from Bursera fagaroides var. fagaroides on Breast Cancer Cell Lines
- (2016) Omar Peña-Morán et al. MOLECULES
- A Phase Ib Study of BEZ235, a Dual Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) and Mammalian Target of Rapamycin (mTOR), in Patients With Advanced Renal Cell Carcinoma
- (2016) Maria I. Carlo et al. ONCOLOGIST
- Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer
- (2016) Sukeshi Patel et al. Oncotarget
- Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase
- (2016) Kosuke Toda et al. NEOPLASIA
- PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells
- (2015) Jiezhong Chen et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents
- (2015) Xuan Liu et al. Future Oncology
- Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line
- (2015) Anna Lewinska et al. TOXICOLOGY IN VITRO
- Cellular and metabolic functions for autophagy in cancer cells
- (2015) Candia M. Kenific et al. TRENDS IN CELL BIOLOGY
- VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
- (2014) Amrita Ahluwalia et al. CURRENT PHARMACEUTICAL DESIGN
- Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy
- (2013) ZHEXING CHANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Emerging regulation and functions of autophagy
- (2013) Patricia Boya et al. NATURE CELL BIOLOGY
- Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 Has a Therapeutic Potential and Sensitizes Cisplatin in Nasopharyngeal Carcinoma
- (2013) Fen Yang et al. PLoS One
- Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines
- (2013) Sanjib Chowdhury et al. PLoS One
- Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model
- (2013) Mir Tahir et al. TOXICOLOGY LETTERS
- Combination of TNF-α and graphene oxide-loaded BEZ235 to enhance apoptosis of PIK3CA mutant colorectal cancer cells
- (2013) Yuhua Cao et al. Journal of Materials Chemistry B
- Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells
- (2012) Hongyan Li et al. CELL BIOCHEMISTRY AND FUNCTION
- PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K–Akt–MDM2 signaling suppression
- (2012) Tran Duc Dung et al. FOOD AND CHEMICAL TOXICOLOGY
- The genetic basis of affective temperament and the bipolar spectrum
- (2012) J R Kelsoe et al. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer
- (2011) Niranjan Awasthi et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K—mTOR pathway in pancreatic adenocarcinoma
- (2011) Olga K. Mirzoeva et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Autophagy and disease: always two sides to a problem
- (2011) Sunandini Sridhar et al. JOURNAL OF PATHOLOGY
- The Role of Autophagy in Cancer: Therapeutic Implications
- (2011) Z. J. Yang et al. MOLECULAR CANCER THERAPEUTICS
- The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer
- (2011) Jatin Roper et al. PLoS One
- The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
- (2011) Michelle C. Mendoza et al. TRENDS IN BIOCHEMICAL SCIENCES
- Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia
- (2010) F. Chiarini et al. CANCER RESEARCH
- Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
- (2010) T.-C. Chou CANCER RESEARCH
- mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
- (2010) Won Jun Oh et al. EMBO JOURNAL
- Novel Expression Patterns of PI3K/Akt/mTOR Signaling Pathway Components in Colorectal Cancer
- (2010) Sara M. Johnson et al. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
- Synergistic Effect of Diosmin and Interferon-α on Metastatic Pulmonary Melanoma
- (2009) Nuria Álvarez et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Constitutive NF- B Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth
- (2009) K. Sakamoto et al. CLINICAL CANCER RESEARCH
- Autophagy in tumour suppression and promotion
- (2009) Andreas Brech et al. Molecular Oncology
- Differential Involvement of Vascular Endothelial Growth Factor in the Survival of Hypoxic Colon Cancer Cells
- (2008) M. Calvani et al. CANCER RESEARCH
- Systemic Treatment of Colorectal Cancer
- (2008) Brian M. Wolpin et al. GASTROENTEROLOGY
- Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK
- (2008) H. C. Dan et al. GENES & DEVELOPMENT
- Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
- (2008) S.-M. Maira et al. MOLECULAR CANCER THERAPEUTICS
- Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
- (2008) Jeffrey A Engelman et al. NATURE MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now