Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy

(2015) Yanping Xiao et al.   Cancer Discovery

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling

(2015) Steffen Ormanns et al.   Oncotarget

Inhibition of JAK1, 2/STAT3 Signaling Induces Apoptosis, Cell Cycle Arrest, and Reduces Tumor Cell Invasion in Colorectal Cancer Cells

(2015) Hua Xiong et al.   NEOPLASIA

Intervening in β-Catenin Signaling by Sulindac Inhibits S100A4-Dependent Colon Cancer Metastasis

(2015) Ulrike Stein et al.   NEOPLASIA

Nuclear Notch3 Expression is Associated with Tumor Recurrence in Patients with Stage II and III Colorectal Cancer

(2014) Tsuyoshi Ozawa et al.   ANNALS OF SURGICAL ONCOLOGY

Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner

(2014) Heyang Xu et al.   BMC CANCER

Epidermal growth factor receptor (EGFR) and prostaglandin-endoperoxide synthase 2 (PTGS2) are prognostic biomarkers for patients with resected colorectal cancer liver metastases

(2014) J A C M Goos et al.   BRITISH JOURNAL OF CANCER

Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity

(2014) Nelson Ung et al.   CANCER BIOLOGY & THERAPY

SDF-1/CXCR4 promotes epithelial–mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway

(2014) Ting-hua Hu et al.   CANCER LETTERS

Evaluation of aflibercept in the treatment of metastatic colorectal cancer

(2014) Teresa Macarulla et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Embelin Reduces Colitis-Associated Tumorigenesis through Limiting IL-6/STAT3 Signaling

(2014) Y. Dai et al.   MOLECULAR CANCER THERAPEUTICS

STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression

(2014) J-Y Wang et al.   ONCOGENE

Molecular mechanism of TGF-β signaling pathway in colon carcinogenesis and status of curcumin as chemopreventive strategy

(2014) Ganesan Ramamoorthi et al.   TUMOR BIOLOGY

Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer

(2014) Y Dai et al.   Cell Death & Disease

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

(2014) Maia Chanrion et al.   Nature Communications

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer

(2014) Paulo Rodrigues et al.   Nature Communications

Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH–DAB1–ABL–RHOGEF Protein TRIO

(2014) Masahiro Sonoshita et al.   Cancer Discovery

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer

(2013) Xi Ai et al.   CANCER BIOLOGY & THERAPY

Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis

(2013) William K.K. Wu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Loss of SMAD4 From Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1+ Myeloid Cells and Facilitate Liver Metastasis

(2013) Yoshiro Itatani et al.   GASTROENTEROLOGY

Hsp90 Inhibitors Promote p53-Dependent Apoptosis through PUMA and Bax

(2013) Kan He et al.   MOLECULAR CANCER THERAPEUTICS

The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression

(2013) Lin Liu et al.   PLoS One

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of targeted agents in metastatic colorectal cancer

(2013) Hans Prenen et al.   Targeted Oncology

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

(2012) Sarah Schwitalla et al.   CANCER CELL

ESM-1 regulates cell growth and metastatic process through activation of NF-κB in colorectal cancer

(2012) Yun Hee Kang et al.   CELLULAR SIGNALLING

Emerging VEGF-receptor inhibitors for colorectal cancer

(2012) Erika Martinelli et al.   EXPERT OPINION ON EMERGING DRUGS

Molecular Markers Predict Distant Metastases After Adjuvant Chemoradiation for Rectal Cancer

(2012) Jun Won Kim et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

(2012) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Honokiol in Combination with Radiation Targets Notch Signaling to Inhibit Colon Cancer Stem Cells

(2012) S. Ponnurangam et al.   MOLECULAR CANCER THERAPEUTICS

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts

(2012) L J A C Hawinkels et al.   ONCOGENE

Global analysis of L1-transcriptomes identified IGFBP-2 as a target of ezrin and NF-κB signaling that promotes colon cancer progression

(2012) A Ben-Shmuel et al.   ONCOGENE

TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1

(2012) D. Peter O'Leary et al.   PLoS One

Focus Issue: Wnt and  -Catenin Signaling in Development and Disease

(2012) N. R. Gough   Science Signaling

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention

(2011) Mary-Clare Cathcart et al.   CANCER AND METASTASIS REVIEWS

Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling

(2011) Yoshihiro Ono et al.   CANCER SCIENCE

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

(2011) Markus F. Neurath et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Roles of VEGF-C and Smad4 in the Lymphangiogenesis, Lymphatic Metastasis, and Prognosis in Colon Cancer

(2011) Xuemei Li et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Notch3 signalling promotes tumour growth in colorectal cancer

(2011) Valentina Serafin et al.   JOURNAL OF PATHOLOGY

S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells

(2011) Ulrike Sack et al.   MOLECULAR BIOLOGY OF THE CELL

Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells

(2011) Hua Xiong et al.   MOLECULAR CARCINOGENESIS

Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms

(2010) William Ka Kei Wu et al.   CANCER LETTERS

Anti-DLL4 Inhibits Growth and Reduces Tumor-Initiating Cell Frequency in Colorectal Tumors with Oncogenic KRAS Mutations

(2010) M. Fischer et al.   CANCER RESEARCH

SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

(2010) Mark Demma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells

(2010) L. Roger et al.   JOURNAL OF CELL SCIENCE

Notch2 Expression Is Decreased in Colorectal Cancer and Related to Tumor Differentiation Status

(2009) Dake Chu et al.   ANNALS OF SURGICAL ONCOLOGY

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

Antimetastatic Role of Smad4 Signaling in Colorectal Cancer

(2009) Bixiang Zhang et al.   GASTROENTEROLOGY

Wnt signaling pathways meet Rho GTPases

(2009) K. Schlessinger et al.   GENES & DEVELOPMENT

Effectiveness of IκB kinase inhibitors in murine colitis-associated tumorigenesis

(2009) Yoku Hayakawa et al.   JOURNAL OF GASTROENTEROLOGY

Double blind randomized phase II study with radiation+5-fluorouracil±celecoxib for resectable rectal cancer

(2009) Annelies Debucquoy et al.   RADIOTHERAPY AND ONCOLOGY

The anti-proliferative potency of celecoxib is not a class effect of coxibs

(2008) Susanne Schiffmann et al.   BIOCHEMICAL PHARMACOLOGY

Extracellular matrix protein  ig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation

(2008) C. Ma et al.   GENES & DEVELOPMENT

Notch1 Expression in Colorectal Carcinoma Determines Tumor Differentiation Status

(2008) Dake Chu et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of signal transducers and activators of transcription in colon cancer

(2007) Lidija Klampfer   Frontiers in Bioscience-Landmark