Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

(2019) Jerzy M. Dziekan et al.   Science Translational Medicine

Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

(2018) Geoffrey W. Birrell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

(2018) Jasmine Chong et al.   NUCLEIC ACIDS RESEARCH

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

(2018) Erick T. Tjhin et al.   PLoS Pathogens

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

(2018) James A. Thomas et al.   Nature Microbiology

Mechanisms of resistance to the partner drugs of artemisinin in the malaria parasite

(2018) Rowena E Martin et al.   CURRENT OPINION IN PHARMACOLOGY

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials

(2018) Christine Moore Sheridan et al.   MALARIA JOURNAL

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia

(2017) Christian M. Parobek et al.   Genome Biology and Evolution

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

(2017) Ghizal Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

Antimalarials inhibit hematin crystallization by unique drug–surface site interactions

(2017) Katy N. Olafson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is the Mitochondrion a Good Malaria Drug Target?

(2017) Christopher D. Goodman et al.   TRENDS IN PARASITOLOGY

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

(2017) Wilson Wong et al.   Nature Microbiology

Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

(2016) Erik L. Allman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

(2016) Darren J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

(2016) Marina Chavchich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasitesPlasmodium falciparum3D7

(2016) Hanafy M. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Dysregulation Induced inPlasmodium falciparumby Dihydroartemisinin and Other Front-Line Antimalarial Drugs

(2015) Simon A. Cobbold et al.   JOURNAL OF INFECTIOUS DISEASES

Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials

(2015) Jill M. Combrinck et al.   MALARIA JOURNAL

Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine

(2015) Katy N. Olafson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

Drug Delivery to the Malaria Parasite Using an Arterolane-Like Scaffold

(2014) Shaun D. Fontaine et al.   ChemMedChem

Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action

(2013) Gloria NS da Silva et al.   MALARIA JOURNAL

Loss of pH Control in Plasmodium falciparum Parasites Subjected to Oxidative Stress

(2013) Donelly A. van Schalkwyk et al.   PLoS One

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

(2013) Selina E. R. Bopp et al.   PLoS Genetics

Cytostatic versus Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth

(2012) Alexander P. Gorka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data

(2012) Darren J. Creek et al.   BIOINFORMATICS

A cross-platform toolkit for mass spectrometry and proteomics

(2012) Matthew C Chambers et al.   NATURE BIOTECHNOLOGY

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimalarial drugs: modes of action and mechanisms of parasite resistance

(2010) Ingrid B Müller et al.   Future Microbiology

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum

(2008) M. D. Lazarus et al.   JOURNAL OF CELL SCIENCE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY