Antimalarial drugs: modes of action and mechanisms of parasite resistance

Plasmodium falciparum Dihydrofolate Reductase and Dihyropteroate Synthase Mutations and the Use of Trimethoprim-Sulfamethoxazole Prophylaxis among Persons Infected with Human Immunodeficiency Virus

(2010) Samuel Malamba et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Five Years of Large-Scale dhfr and dhps Mutation Surveillance Following the Phased Implementation of Artesunate Plus Sulfadoxine-Pyrimethamine in Maputo Province, Southern Mozambique

(2010) Jaishree Raman et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Association of Microsatellite Variations of Plasmodium falciparum Na+/H+ Exchanger (Pfnhe-1) Gene with Reduced In Vitro Susceptibility to Quinine: Lack of Confirmation in Clinical Isolates from Africa

(2010) Valérie Andriantsoanirina et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Investigations into the Role of the Plasmodium falciparum SERCA (PfATP6) L263E Mutation in Artemisinin Action and Resistance

(2010) S. G. Valderramos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Sensitivity of Plasmodium falciparum Clinical Isolates from the China-Myanmar Border Area to Quinine and Association with Polymorphism in the Na+/H+ Exchanger

(2010) H. Meng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Absence of Association between Piperaquine In Vitro Responses and Polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe Genes in Plasmodium falciparum

(2010) S. Briolant et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Exploring the Contribution of Candidate Genes to Artemisinin Resistance in Plasmodium falciparum

(2010) M. Imwong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76

(2010) K. Beshir et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya

(2010) J. Okombo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hematin−Hematin Self-Association States Involved in the Formation and Reactivity of the Malaria Parasite Pigment, Hemozoin

(2010) Nectarios Klonis et al.   BIOCHEMISTRY

What made sesquiterpene lactones reach cancer clinical trials?

(2010) Akram Ghantous et al.   DRUG DISCOVERY TODAY

Malaria: what can apes teach humans?

(2010) Janet Cox-Singh   Future Microbiology

High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia

(2010) Tim J. C. Anderson et al.   JOURNAL OF INFECTIOUS DISEASES

Two Nonrecombining Sympatric Forms of the Human Malaria ParasitePlasmodium ovaleOccur Globally

(2010) Colin J. Sutherland et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial

(2010) Antoinette K Tshefu et al.   LANCET

The pharmaceutical death-ride of dihydroartemisinin

(2010) Frans Jansen   MALARIA JOURNAL

Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009

(2010) Ngo V Thanh et al.   MALARIA JOURNAL

Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations

(2010) Sankar Sridaran et al.   MALARIA JOURNAL

Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

(2010) Ana Afonso et al.   MALARIA JOURNAL

Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue

(2010) Perri Pleeter et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Priming the antimalarial pipeline

(2010) David A. Fidock   NATURE

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

(2010) Jianbing Mu et al.   NATURE GENETICS

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum

(2010) Inbarani Naidoo et al.   TRENDS IN PARASITOLOGY

The ABCs of multidrug resistance in malaria

(2010) Jan B. Koenderink et al.   TRENDS IN PARASITOLOGY

The RTS,S malaria vaccine

(2010) Sofia Casares et al.   VACCINE

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

(2010) Stephanie G. Valderramos et al.   PLoS Pathogens

Exploiting Structural Analysis,in SilicoScreening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum Malaria

(2009) Tina Dasgupta et al.   ACS Chemical Biology

Molecular Correlates of High-Level Antifolate Resistance in Rwandan Children with Plasmodium falciparum Malaria

(2009) C. Karema et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium falciparum Na+/H+ Exchanger 1 Transporter Is Involved in Reduced Susceptibility to Quinine

(2009) M. Henry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymorphism in PfMRP1 (Plasmodium falciparum Multidrug Resistance Protein 1) Amino Acid 1466 Associated with Resistance to Sulfadoxine-Pyrimethamine Treatment

(2009) S. Dahlstrom et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activity of Antifolate and Polymorphism in Dihydrofolate Reductase of Plasmodium falciparum Isolates from the Kenyan Coast: Emergence of Parasites with Ile-164-Leu Mutation

(2009) S. M. Kiara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel pfdhps Haplotypes among Imported Cases of Plasmodium falciparum Malaria in the United Kingdom

(2009) C. J. Sutherland et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chloroquine Transport inPlasmodium falciparum. 1. Influx and Efflux Kinetics for Live Trophozoite Parasites Using a Novel Fluorescent Chloroquine Probe

(2009) Mynthia Cabrera et al.   BIOCHEMISTRY

Reduced Digestive Vacuolar Accumulation of Chloroquine Is Not Linked to Resistance to Chloroquine Toxicity

(2009) Mynthia Cabrera et al.   BIOCHEMISTRY

Chloroquine Transport inPlasmodium falciparum. 2. Analysis of PfCRT-Mediated Drug Transport Using Proteoliposomes and a Fluorescent Chloroquine Probe

(2009) Michelle F. Paguio et al.   BIOCHEMISTRY

Shape- and Chemical Feature-Based 3D-Pharmacophore Model Generation and Virtual Screening: Identification of Potential Leads forP. falciparumDHFR Enzyme Inhibition

(2009) Legesse Adane et al.   Chemical Biology & Drug Design

The Global Portfolio of New Antimalarial Medicines Under Development

(2009) P Olliaro et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hybrid Drugs for Malaria

(2009) J. Walsh et al.   CURRENT PHARMACEUTICAL DESIGN

Resistance to antimalarial compounds: Methods and applications

(2009) Benoit Witkowski et al.   DRUG RESISTANCE UPDATES

Existing antimalarial agents and malaria-treatment strategies

(2009) Umberto D'Alessandro   EXPERT OPINION ON PHARMACOTHERAPY

Discovery, mechanisms of action and combination therapy of artemisinin

(2009) Liwang Cui et al.   Expert Review of Anti-Infective Therapy

Molecular and physiologic basis of quinoline drug resistance inPlasmodium falciparummalaria

(2009) Paul D Roepe   Future Microbiology

Disruption of aPlasmodium falciparumMultidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

(2009) Dipak Kumar Raj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emergence of an Unusual Sulfadoxine‐Pyrimethamine Resistance Pattern and a Novel K540N Mutation in Dihydropteroate Synthetase inPlasmodium falciparumIsolates Obtained from Car Nicobar Island, India, after the 2004 Tsunami

(2009) Vanshika Lumb et al.   JOURNAL OF INFECTIOUS DISEASES

Plasmodium falciparumMultidrug Resistance Protein 1 and Artemisinin‐Based Combination Therapy in Africa

(2009) Sabina Dahlström et al.   JOURNAL OF INFECTIOUS DISEASES

In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa

(2009) Christin Sisowath et al.   JOURNAL OF INFECTIOUS DISEASES

Artemisinin resistance on the Thai–Cambodian border

(2009) Olaf Müller et al.   LANCET

Countries race to contain resistance to key antimalarial

(2009) Udani Samarasekera   LANCET

A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria

(2009) Stéphane Picot et al.   MALARIA JOURNAL

Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane

(2009) Reginald A Kavishe et al.   MALARIA JOURNAL

Chloroquine resistance before and after its withdrawal in Kenya

(2009) Leah Mwai et al.   MALARIA JOURNAL

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

(2009) Louis J. Nkrumah et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

The development of the RTS,S malaria vaccine candidate: challenges and lessons

(2009) W. R. BALLOU   PARASITE IMMUNOLOGY

DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures

(2009) Abdul Mannan et al.   PLANT CELL REPORTS

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

(2009) E. R. Lozovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geographic patterns ofPlasmodium falciparumdrug resistance distinguished by differential responses to amodiaquine and chloroquine

(2009) Juliana Martha Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter

(2009) R. E. Martin et al.   SCIENCE

Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria

(2009) Richard J. Pearce et al.   PLOS MEDICINE

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

(2009) Neekesh V Dharia et al.   GENOME BIOLOGY

Association between chloroquine resistance phenotypes and point mutations in pfcrt and pfmdr1 in Plasmodium falciparum isolates from Thailand

(2008) Kanchana Rungsihirunrat et al.   ACTA TROPICA

Plasmodium falciparum Strains Harboring Dihydrofolate Reductase with the I164L Mutation Are Absent in Malawi and Zambia Even under Antifolate Drug Pressure

(2008) E. Ochong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chloroquine Resistance-Conferring Mutations in pfcrt Give Rise to a Chloroquine-Associated H+ Leak from the Malaria Parasite's Digestive Vacuole

(2008) A. M. Lehane et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discordant Patterns of Genetic Variation at Two Chloroquine Resistance Loci in Worldwide Populations of the Malaria Parasite Plasmodium falciparum

(2008) R. K. Mehlotra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

(2008) Carmony L. Hartwig et al.   BIOCHEMICAL PHARMACOLOGY

Drug resistance and genetic mapping in Plasmodium falciparum

(2008) Karen Hayton et al.   CURRENT GENETICS

Inhibition of Efflux of Quinolines as New Therapeutic Strategy in Malaria

(2008) Maud Henry et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Malaria: progress, perils, and prospects for eradication

(2008) Brian M. Greenwood et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma Folate Level and High‐Dose Folate Supplementation Predict Sulfadoxine‐Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria

(2008) Anna M. van Eijk et al.   JOURNAL OF INFECTIOUS DISEASES

Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia

(2008) Mtawa AP Mkulama et al.   MALARIA JOURNAL

Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil

(2008) Colin J Sutherland et al.   MALARIA JOURNAL

Dissecting the components of quinine accumulation in Plasmodium falciparum

(2008) Cecilia P. Sanchez et al.   MOLECULAR MICROBIOLOGY

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-Wide Compensatory Changes Accompany Drug- Selected Mutations in the Plasmodium falciparum crt Gene

(2008) Hongying Jiang et al.   PLoS One

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE

Revising antimalarial drug policy in Central America: experience in Panama

(2008) Jose E. Calzada et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Antifolate resistance in Africa and the 164-dollar question

(2008) John E. Hyde   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics

(2008) Erica L. Dahl et al.   TRENDS IN PARASITOLOGY

Adaptive Copy Number Evolution in Malaria Parasites

(2008) Shalini Nair et al.   PLoS Genetics

Plasmodium knowlesi: The Fifth Human Malaria Parasite

(2007) N. J. White   CLINICAL INFECTIOUS DISEASES