Neuroinflammation in heart failure: new insights for an old disease

Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure

(2019) David C Andrade et al.   CLINICAL SCIENCE

Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: does ejection fraction matter?

(2018) David C. Andrade et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Blood-borne interleukin-1β acts on the subfornical organ to upregulate the sympathoexcitatory milieu of the hypothalamic paraventricular nucleus

(2018) Shun-Guang Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats

(2018) Yang Yu et al.   NEUROSCIENCE

Vascular Cognitive Impairment Linked to Brain Endothelium Inflammation in Early Stages of Heart Failure in Mice

(2018) Mateusz G. Adamski et al.   Journal of the American Heart Association

Clinical and experimental aspects of breathing modulation by inflammation

(2018) Fernando Peña-Ortega   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Long-term vagal stimulation for heart failure: Eighteen month results from the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) trial

(2017) Gaetano M. De Ferrari et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure

(2017) David C. Andrade et al.   JOURNAL OF APPLIED PHYSIOLOGY

The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons

(2017) Nick J. Simpson et al.   JOURNAL OF NEUROPHYSIOLOGY

KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure

(2017) Noah J. Marcus et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiac diastolic and autonomic dysfunction are aggravated by central chemoreflex activation in heart failure with preserved ejection fraction rats

(2017) Camilo Toledo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials

(2017) Michael Böhm et al.   LANCET

C1 neurons mediate a stress-induced anti-inflammatory reflex in mice

(2017) Chikara Abe et al.   NATURE NEUROSCIENCE

Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure

(2017) Rodrigo Del Rio et al.   Scientific Reports

Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure

(2016) Shun-Guang Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neuroinflammatory mechanisms of hypertension

(2016) Pawel J. Winklewski et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The splanchnic anti-inflammatory pathway: could it be the efferent arm of the inflammatory reflex?

(2016) D. Martelli et al.   EXPERIMENTAL PHYSIOLOGY

Angiotensin II regulation of angiotensin-converting enzymes in spontaneously hypertensive rat primary astrocyte cultures

(2016) Yugandhar V. Gowrisankar et al.   JOURNAL OF NEUROCHEMISTRY

PRESSURE-OVERLOAD INDUCED LV HYPERTROPHY AND DYSFUNCTION: CRITICAL ROLES OF CAMKII AND P38 MAP KINASE IN ER STRESS SIGNALING PATHWAY

(2016) Xing Chen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Neurohormonal activation in heart failure with reduced ejection fraction

(2016) Justin Hartupee et al.   Nature Reviews Cardiology

Dynamic changes in the relationship of microglia to cardiovascular neurons in response to increases and decreases in blood pressure

(2016) Komal Kapoor et al.   NEUROSCIENCE

Alerted microglia and the sympathetic nervous system: A novel form of microglia in the development of hypertension

(2016) Komal Kapoor et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis

(2016) Jody Groenendyk et al.   PLoS One

P2X7 Receptor Suppression Preserves Blood-Brain Barrier through Inhibiting RhoA Activation after Experimental Intracerebral Hemorrhage in Rats

(2016) Hengli Zhao et al.   Scientific Reports

Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertension

(2015) W.-W. Chen et al.   Acta Physiologica

Enhanced astroglial GABA uptake in heart failure

(2015) Hyun-Woo Kim et al.   Channels

Inflammatory cytokines as biomarkers in heart failure

(2015) Thor Ueland et al.   CLINICA CHIMICA ACTA

TNF and angiotensin type 1 receptors interact in the brain control of blood pressure in heart failure

(2015) Tymoteusz Żera et al.   CYTOKINE

Selective carotid body ablation in experimental heart failure: a new therapeutic tool to improve cardiorespiratory control

(2015) Rodrigo Del Rio et al.   EXPERIMENTAL PHYSIOLOGY

Inflammation in HFpEF: Key or circumstantial?

(2015) Vanessa van Empel et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Angiotensin Ⅱ Activates MCP-1 and Induces Cardiac Hypertrophy and Dysfunction via Toll-like Receptor 4

(2015) Susumu Matsuda et al.   Journal of Atherosclerosis and Thrombosis

Antagonism of PACAP or Microglia Function Worsens the Cardiovascular Consequences of Kainic-Acid-Induced Seizures in Rats

(2015) A. M. Bhandare et al.   JOURNAL OF NEUROSCIENCE

Compromised blood-brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension

(2015) V. C. Biancardi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brain mechanisms of sympathetic activation in heart failure: Roles of the renin-angiotensin system, nitric oxide and pro-inflammatory cytokines (Review)

(2015) BIN XU et al.   Molecular Medicine Reports

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Microglial P2X7 receptor in the hypothalamic paraventricular nuclei contributes to sympathoexcitatory responses in acute myocardial infarction rat

(2015) Dongshu Du et al.   NEUROSCIENCE LETTERS

Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure

(2015) David C. Andrade et al.   Biomed Research International

Tumor Necrosis Factor - Alpha Is Essential for Angiotensin II-Induced Ventricular Remodeling: Role for Oxidative Stress

(2015) Srinivas Sriramula et al.   PLoS One

Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure

(2014) Kengo Isegawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Attenuation of microglial and neuronal activation in the brain by ICV minocycline following myocardial infarction

(2014) Melissa Dworak et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Fosbgene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

(2014) Hiroko Nomaru et al.   GLIA

Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation

(2014) Ana I. Rodriguez-Perez et al.   GLIA

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Direct Pro-Inflammatory Effects of Prorenin on Microglia

(2014) Peng Shi et al.   PLoS One

Vagal Stimulation in Heart Failure

(2014) Gaetano M. De Ferrari   Journal of Cardiovascular Translational Research

Effects of Interleukin-1 Blockade With Anakinra on Aerobic Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction (from the D-HART Pilot Study)

(2013) Benjamin Wallace Van Tassell et al.   AMERICAN JOURNAL OF CARDIOLOGY

Telmisartan Reduces Mortality and Left Ventricular Hypertrophy With Sympathoinhibition in Rats with Hypertension and Heart Failure

(2013) T. Kishi et al.   AMERICAN JOURNAL OF HYPERTENSION

Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN

(2013) Neeru M. Sharma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of exercise training on SFO-mediated sympathoexcitation during chronic heart failure

(2013) Tamra L. Llewellyn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

C1 neurons: the body's EMTs

(2013) Patrice G. Guyenet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons

(2013) Gang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Angiotensin II causes imbalance between pro- and anti-inflammatory cytokines by modulating GSK-3β in neuronal culture

(2013) Deepmala Agarwal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Forecasting the Impact of Heart Failure in the United States

(2013) Paul A. Heidenreich et al.   Circulation-Heart Failure

The paraventricular nucleus and heart failure

(2013) Susan Pyner   EXPERIMENTAL PHYSIOLOGY

Subfornical Organ Mediates Sympathetic and Hemodynamic Responses to Blood-Borne Proinflammatory Cytokines

(2013) Shun-Guang Wei et al.   HYPERTENSION

Circulating Angiotensin II Gains Access to the Hypothalamus and Brain Stem During Hypertension via Breakdown of the Blood–Brain Barrier

(2013) Vinicia Campana Biancardi et al.   HYPERTENSION

Regulation of the sympathetic nervous system by nitric oxide and oxidative stress in the rostral ventrolateral medulla: 2012 Academic Conference Award from the Japanese Society of Hypertension

(2013) Takuya Kishi   HYPERTENSION RESEARCH

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

(2013) Jessica M. Crain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure

(2013) Noah J. Marcus et al.   JOURNAL OF PHYSIOLOGY-LONDON

Carotid Chemoreceptor Ablation Improves Survival in Heart Failure

(2013) Rodrigo Del Rio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary

(2013) Clyde W. Yancy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Expression of angiotensin II and its receptors in activated microglia in experimentally induced cerebral ischemia in the adult rats

(2013) Chun-Yun Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Depression after myocardial infarction: TNF-α-induced alterations of the blood–brain barrier and its putative therapeutic implications

(2013) Hui Liu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

(2013) Christian Giaume et al.   Frontiers in Pharmacology

Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats

(2012) Evgeniy S. Potapenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Changes in GABAergic inputs in the paraventricular nucleus maintain sympathetic vasomotor tone in chronic heart failure

(2012) B.A. Carillo et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure following myocardial infarction in rats

(2012) Nephtali Marina et al.   BASIC RESEARCH IN CARDIOLOGY

Differential distribution and activation of microglia in the brain of male C57BL/6J mice

(2012) Ting-Ting Yang et al.   Brain Structure & Function

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Does angiotensin II cross the blood–brain barrier?

(2012) Dusan Roncevic   HYPERTENSION RESEARCH

Heart failure as an autonomic nervous system dysfunction

(2012) Takuya Kishi   Journal of Cardiology

The projection and synaptic organisation of NTS afferent connections with presympathetic neurons, GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus

(2012) V.S. Affleck et al.   NEUROSCIENCE

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

(2012) Carlos Barcia et al.   Scientific Reports

The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?

(2012) Wencheng Li et al.   International Journal of Hypertension

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

(2011) Alia Shatanawi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NF-κB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure

(2011) Yu-Ming Kang et al.   BASIC RESEARCH IN CARDIOLOGY

Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide

(2011) Anuradha Guggilam et al.   BASIC RESEARCH IN CARDIOLOGY

Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension

(2011) V.A. Braga et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Telmisartan for the management of patients at high cardiovascular risk

(2011) Luis M. Ruilope   CURRENT MEDICAL RESEARCH AND OPINION

The role of the subfornical organ in angiotensin II-salt hypertension in the rat

(2011) John W. Osborn et al.   EXPERIMENTAL PHYSIOLOGY

Contribution of excitatory amino acid receptors of the retrotrapezoid nucleus to the sympathetic chemoreflex in rats

(2011) Ana C. Takakura et al.   EXPERIMENTAL PHYSIOLOGY

Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure

(2011) Hiroo Kumagai et al.   HYPERTENSION RESEARCH

Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

(2011) James B. Strait et al.   Heart Failure Clinics

Angiotensin II-induced upregulation of AT1 receptor expression: sequential activation of NF-κB and Elk-1 in neurons

(2010) Amit K. Mitra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Microglia activation in the hypothalamic PVN following myocardial infarction

(2010) Indrajeetsinh Rana et al.   BRAIN RESEARCH

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

(2010) Keigan M. Park et al.   CELLULAR SIGNALLING

Vagus nerve stimulation in experimental heart failure

(2010) Hani N. Sabbah et al.   HEART FAILURE REVIEWS

Brain Perivascular Macrophages and the Sympathetic Response to Inflammation in Rats After Myocardial Infarction

(2010) Yang Yu et al.   HYPERTENSION

Brain Microglial Cytokines in Neurogenic Hypertension

(2010) Peng Shi et al.   HYPERTENSION

MCP-1 Contributes to Arteriovenous Fistula Failure

(2010) J. P. Juncos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

TNF activates astrocytes and catecholaminergic neurons in the solitary nucleus: Implications for autonomic control

(2009) Gerlinda E. Hermann et al.   BRAIN RESEARCH

Brain tumour necrosis factor-  modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

Brain cytokines as neuromodulators in cardiovascular control

(2009) Peng Shi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Role of the renin–angiotensin–aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction

(2009) Sebastiano Sciarretta et al.   CLINICAL SCIENCE

Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation

(2009) S. Pyner   JOURNAL OF CHEMICAL NEUROANATOMY

Altered balance of γ-aminobutyric acidergic and glutamatergic afferent inputs in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus of renovascular hypertensive rats

(2009) Vinicia Campana Biancardi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The inflammatory response in the MPTP model of Parkinson’s disease is mediated by brain angiotensin: relevance to progression of the disease

(2009) Belen Joglar et al.   JOURNAL OF NEUROCHEMISTRY

The Sympathetic Nervous System in Heart Failure

(2009) Filippos Triposkiadis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Differential regulation of the central neural cardiorespiratory system by metabotropic neurotransmitters

(2009) P. M. Pilowsky et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cytokine blockade attenuates sympathoexcitation in heart failure: Cross-talk between nNOS, AT-1R and cytokines in the hypothalamic paraventricular nucleus

(2008) Anuradha Guggilam et al.   EUROPEAN JOURNAL OF HEART FAILURE

The renin-angiotensin-aldosterone system (RAAS) and cardiac arrhythmias

(2008) Shahriar Iravanian et al.   HEART RHYTHM

Tonic Glutamatergic Input in the Rostral Ventrolateral Medulla Is Increased in Rats With Chronic Heart Failure

(2008) Wei-Zhong Wang et al.   HYPERTENSION