The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues

Fibroblast Growth Factor 21 and Browning of White Adipose Tissue

(2019) Daniel Cuevas-Ramos et al.   Frontiers in Physiology

FOXK1 and FOXK2 regulate aerobic glycolysis

(2019) Valentina Sukonina et al.   NATURE

Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?

(2019) Thierry Léveillard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of brown and beige adipose tissue in glycaemic control

(2019) Katarina Klepac et al.   MOLECULAR ASPECTS OF MEDICINE

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

Lactate production is a prioritised feature of adipocyte metabolism

(2019) James R. Krycer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restricting glycolysis impairs brown adipocyte glucose and oxygen consumption

(2018) Sally Winther et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Stereoselective effects of lactate enantiomers on the enhancement of 3T3-L1 adipocyte differentiation

(2018) Naoki Harada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

Brown adipocytes postnatally arise through both differentiation from progenitors and conversion from white adipocytes in Syrian hamster

(2018) Yuko Okamatsu-Ogura et al.   JOURNAL OF APPLIED PHYSIOLOGY

Exercise-induced ‘browning’ of adipose tissues

(2018) Peter Aldiss et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Intracellular glycolysis in brown adipose tissue is essential for optogenetically induced nonshivering thermogenesis in mice

(2018) Jae Hoon Jeong et al.   Scientific Reports

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation

(2018) Ntsiki M. Held et al.   Scientific Reports

Uncoupling protein 1 expression in adipocytes derived from skeletal muscle fibro/adipogenic progenitors is under genetic and hormonal control

(2018) Tatiane Gorski et al.   Journal of Cachexia Sarcopenia and Muscle

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses

(2018) Alexandre Morrot et al.   Frontiers in Oncology

Brown adipocyte glucose metabolism: a heated subject

(2018) Mohammed K Hankir et al.   EMBO REPORTS

An unexpected trigger for calorie burning in brown fat

(2018) Sheng Hui et al.   NATURE

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms

(2017) Edward T. Chouchani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease

(2017) Matthias J. Betz et al.   Nature Reviews Endocrinology

Uncoupling protein 1 controls reactive oxygen species in brown adipose tissue

(2017) Martin Jastroch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxy-Carboxylic Acid Receptor Actions in Metabolism

(2017) Stefan Offermanns   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Lives and Times of Brown Adipokines

(2017) Francesc Villarroya et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells

(2017) Nami Kim et al.   Scientific Reports

MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism

(2017) Charlotte Petersen et al.   Scientific Reports

Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue

(2017) Kanta Chechi et al.   Scientific Reports

Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway

(2016) Y. Jeanson et al.   BIOCHEMICAL JOURNAL

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

(2016) V. Albert et al.   EMBO Molecular Medicine

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice

(2016) Satoko Hanatani et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Lactate metabolism is associated with mammalian mitochondria

(2016) Ying-Jr Chen et al.   Nature Chemical Biology

Pdcd4 restrains the self-renewal and white-to-beige transdifferentiation of adipose-derived stem cells

(2016) Y Bai et al.   Cell Death & Disease

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism

(2015) Qin Hao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

(2015) Labros S. Sidossis et al.   Cell Metabolism

Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue

(2015) Craig Porter et al.   SHOCK

A New Role for Browning as a Redox and Stress Adaptive Mechanism?

(2015) Yannick Jeanson et al.   Frontiers in Endocrinology

Oxygen Deprivation and the Cellular Response to Hypoxia in Adipocytes – Perspectives on White and Brown Adipose Tissues in Obesity

(2015) Paul Trayhurn et al.   Frontiers in Endocrinology

Surgical injury induces local and distant adipose tissue browning

(2015) Alban Longchamp et al.   Adipocyte

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

(2014) A. Carriere et al.   DIABETES

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

(2014) Serkan Kir et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet

(2012) Shireesh Srivastava et al.   FASEB JOURNAL

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Exercise as a new physiological stimulus for brown adipose tissue activity

(2012) R. De Matteis et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Modulation of adipokine production, glucose uptake and lactate release in human adipocytes by small changes in oxygen tension

(2011) I. Stuart Wood et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

Histochemical demonstration of monocarboxylate transporters in mouse brown adipose tissue

(2009) Toshihiko Iwanaga et al.   BIOMEDICAL RESEARCH-TOKYO

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

An ancient look at UCP1

(2008) Martin Klingenspor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Reservoir of Brown Adipocyte Progenitors in Human Skeletal Muscle

(2008) Mihaela Crisan et al.   STEM CELLS