A New Role for Browning as a Redox and Stress Adaptive Mechanism?

A stringent validation of mouse adipose tissue identity markers

(2015) Jasper M. A. de Jong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Immune Regulation of Metabolic Homeostasis in Health and Disease

(2015) Jonathan R. Brestoff et al.   CELL

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

(2015) Mark P. Jedrychowski et al.   Cell Metabolism

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

(2015) Labros S. Sidossis et al.   Cell Metabolism

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

(2015) Xiaomeng Liu et al.   ENDOCRINOLOGY

Cellular origins of cold-induced brown adipocytes in adult mice

(2015) Yun-Hee Lee et al.   FASEB JOURNAL

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

(2015) Ruidan Xue et al.   NATURE MEDICINE

Genetic and functional characterization of clonally derived adult human brown adipocytes

(2015) Kosaku Shinoda et al.   NATURE MEDICINE

Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue

(2015) Craig Porter et al.   SHOCK

Human White and Brite Adipogenesis is Supported by MSCA1 and is Impaired by Immune Cells

(2015) David Estève et al.   STEM CELLS

Adipokines in health and disease

(2015) Mathias Fasshauer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Glutathione Decrement Drives Thermogenic Program In Adipose Cells

(2015) Daniele Lettieri Barbato et al.   Scientific Reports

Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

(2015) Anne-Laure Poher et al.   Frontiers in Physiology

Oxygen Deprivation and the Cellular Response to Hypoxia in Adipocytes – Perspectives on White and Brown Adipose Tissues in Obesity

(2015) Paul Trayhurn et al.   Frontiers in Endocrinology

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

(2014) A. Carriere et al.   DIABETES

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

(2014) Jakob D Wikstrom et al.   EMBO JOURNAL

Vascular rarefaction mediates whitening of brown fat in obesity

(2014) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

(2014) Serkan Kir et al.   NATURE

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Irisin as a muscle-derived hormone stimulating thermogenesis – A critical update

(2014) Tobias Hofmann et al.   PEPTIDES

Role of IL-6 in Exercise Training- and Cold-Induced UCP1 Expression in Subcutaneous White Adipose Tissue

(2014) Jakob G. Knudsen et al.   PLoS One

Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

(2014) S.-H. Ro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis

(2014) Domenico Tupone et al.   Frontiers in Neuroscience

The ω6-fatty acid, arachidonic acid, regulates the conversion of white to brite adipocyte through a prostaglandin/calcium mediated pathway

(2014) Didier F. Pisani et al.   Molecular Metabolism

An endocrine role for brown adipose tissue?

(2013) Joan Villarroya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipocyte lineages: Tracing back the origins of fat

(2013) Joan Sanchez-Gurmaches et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brown Adipose Tissue Thermogenesis

(2013) Ross A. Mund et al.   Cardiology in Review

Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): The next generation of peroxisome proliferator-activated receptor α-agonists

(2013) Jean-Charles Fruchart   Cardiovascular Diabetology

Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity

(2013) Yihai Cao   Cell Metabolism

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

Vascular endothelial growth factor is important for brown adipose tissue development and maintenance

(2013) Mandrita Bagchi et al.   FASEB JOURNAL

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Nebivolol induces, via β3 adrenergic receptor, lipolysis, uncoupling protein 1, and reduction of lipid droplet size in human adipocytes

(2013) Marica Bordicchia et al.   JOURNAL OF HYPERTENSION

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

The role of thyroid hormone and brown adipose tissue in energy homoeostasis

(2013) Antonio C Bianco et al.   Lancet Diabetes & Endocrinology

White and brown adipose stem cells: From signaling to clinical implications

(2012) Carolyn Algire et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice

(2012) M. Tsoli et al.   CANCER RESEARCH

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

(2012) Joan Sanchez-Gurmaches et al.   Cell Metabolism

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans

(2012) T Yoneshiro et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Exercise as a new physiological stimulus for brown adipose tissue activity

(2012) R. De Matteis et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

The adipose organ: white-brown adipocyte plasticity and metabolic inflammation

(2012) A. Smorlesi et al.   Obesity Reviews

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Thiazolidinediones and PPARγ agonists: time for a reassessment

(2012) Bertrand Cariou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

β-adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure

(2012) Sheila Collins   Frontiers in Endocrinology

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

(2011) Tomas B. Waldén et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

The cachexia score (CASCO): a new tool for staging cachectic cancer patients

(2011) Josep M. Argilés et al.   Journal of Cachexia Sarcopenia and Muscle

Uncoupling Protein 1 of Brown Adipocytes, the Only Uncoupler: A Historical Perspective

(2011) Daniel Ricquier   Frontiers in Endocrinology

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Brown Fat and the Myth of Diet-Induced Thermogenesis

(2010) Leslie P. Kozak   Cell Metabolism

Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks

(2010) S Collins et al.   INTERNATIONAL JOURNAL OF OBESITY

UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

(2010) Lise Madsen et al.   PLoS One

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

From bench to bedside: novel mechanisms and therapeutic advances through the development of selective peroxisome proliferator-activated receptor γ modulators

(2009) George L Blackburn   AMERICAN JOURNAL OF CLINICAL NUTRITION

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

(2008) Thien T. Tran et al.   Cell Metabolism

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

(2008) S. Kajimura et al.   GENES & DEVELOPMENT

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

A Reservoir of Brown Adipocyte Progenitors in Human Skeletal Muscle

(2008) Mihaela Crisan et al.   STEM CELLS