The role of autophagy in brown and beige adipose tissue plasticity

The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic β cells and adipocytes

(2019) Callie A. S. Corsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis

(2019) Montserrat Cairó et al.   EMBO REPORTS

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning

(2019) Camilla Pellegrini et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes

(2018) Chen Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Nature's fat-burning machine: brown adipose tissue in a hibernating mammal

(2018) Mallory A. Ballinger et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

(2018) Xiaodan Lu et al.   Science Signaling

Mitophagy is required for brown adipose tissue mitochondrial homeostasis during cold challenge

(2018) Yuan Lu et al.   Scientific Reports

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

(2018) Xiaodan Lu et al.   Science Signaling

Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes

(2018) Didier F. Pisani et al.   Molecular Metabolism

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Parkin-mediated mitophagy is downregulated in browning of white adipose tissue

(2017) David Taylor et al.   Obesity

ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism

(2017) Aishwarya Sathyanarayan et al.   Cell Reports

Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades

(2017) Michael J. Gaudry et al.   Science Advances

SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes

(2017) Chia Rou Yeo et al.   Scientific Reports

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Hormonal and nutritional signalling in the control of brown and beige adipose tissue activation and recruitment

(2016) Marta Giralt et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

(2016) Nuria Martinez-Lopez et al.   Cell Metabolism

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

(2016) Cassie M. Tran et al.   DIABETES

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity

(2016) Marc J. Tol et al.   DIABETES

Thermogenic activation represses autophagy in brown adipose tissue

(2016) M Cairó et al.   INTERNATIONAL JOURNAL OF OBESITY

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

(2016) Dianxin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3

(2016) Tizhong Shan et al.   Nature Communications

mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold

(2016) Sébastien M. Labbé et al.   Scientific Reports

Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

(2015) Jaime L. Schneider et al.   AGING CELL

The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase

(2015) Sim Namkoong et al.   Autophagy

Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1

(2015) Yulia Haim et al.   Autophagy

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

How Mitochondrial Dynamism Orchestrates Mitophagy

(2015) O. S. Shirihai et al.   CIRCULATION RESEARCH

DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity

(2015) Hedi Soussi et al.   DIABETES

BNIP3 is essential for mitochondrial bioenergetics during adipocyte remodelling in mice

(2015) Jin Woo Choi et al.   DIABETOLOGIA

Mitochondrial Turnover

(2015) Emilia Gospodarska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in adipose tissue of patients with obesity and type 2 diabetes

(2015) J. Kosacka et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion

(2015) Hanzhi Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic remodeling of white adipose tissue in obesity

(2014) Timothy D. Cummins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch

(2014) Xinxin Xiang et al.   DIABETES

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

(2014) Andrea Armani et al.   FASEB JOURNAL

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation

(2013) Chongben Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development

(2013) Nuria Martinez-Lopez et al.   EMBO REPORTS

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

Transactivation of Atg4b by C/EBPβ Promotes Autophagy To Facilitate Adipogenesis

(2013) Liang Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Autophagy Activity Is Up-Regulated in Adipose Tissue of Obese Individuals and Modulates Proinflammatory Cytokine Expression

(2012) H. J. Jansen et al.   ENDOCRINOLOGY

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

(2012) E. Itakura et al.   JOURNAL OF CELL SCIENCE

p62 Links β-adrenergic input to mitochondrial function and thermogenesis

(2012) Timo D. Müller et al.   JOURNAL OF CLINICAL INVESTIGATION

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Autophagy regulates inflammation in adipocytes

(2011) Takeshi Yoshizaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

(2011) Kye-Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis

(2011) Paola C. Zucchi et al.   MOLECULAR BIOLOGY OF THE CELL

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Altered Autophagy in Human Adipose Tissues in Obesity

(2010) Julia Kovsan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Unknown

(2010) Anita Ost et al.   MOLECULAR MEDICINE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Targeted deletion ofautophagy-related 5(atg5) impairs adipogenesis in a cellular model and in mice

(2009) Rebecca Baerga et al.   Autophagy

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE