Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning

FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism

(2018) Max Friesen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elevated TGF β2 serum levels in Emery-Dreifuss Muscular Dystrophy: Implications for myocyte and tenocyte differentiation and fibrogenic processes

(2018) Pia Bernasconi et al.   Nucleus

Elevated TGF β2 serum levels in Emery-Dreifuss Muscular Dystrophy: Implications for myocyte and tenocyte differentiation and fibrogenic processes

(2018) Pia Bernasconi et al.   Nucleus

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS

(2018) Elisabetta Mattioli et al.   AGING CELL

Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins

(2017) Chen-Yu Liao et al.   Cell Discovery

Distinct functions of PPARγ isoforms in regulating adipocyte plasticity

(2016) Dylan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline

(2016) Rebecca J. Brown et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Convertible visceral fat as a therapeutic target to curb obesity

(2016) Antonio Giordano et al.   NATURE REVIEWS DRUG DISCOVERY

Rapamycin treatment of Mandibuloacral Dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics

(2016) Vittoria Cenni et al.   Aging-US

Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell

(2016) Arantza Infante et al.   Aging-US

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Congenital generalized lipodystrophies—new insights into metabolic dysfunction

(2015) Nivedita Patni et al.   Nature Reviews Endocrinology

TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation

(2015) Dzmitry G. Batrakou et al.   PLoS One

Insulin resistance and impaired adipogenesis

(2015) Birgit Gustafson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins

(2015) Camilla Evangelisti et al.   Oncotarget

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

(2014) Andrea Armani et al.   FASEB JOURNAL

Diverse lamin-dependent mechanisms interact to control chromatin dynamics

(2014) Daria Camozzi et al.   Nucleus

Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation

(2013) Chongben Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle

(2013) Yang Liu et al.   CELLULAR SIGNALLING

Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor γ (PPARγ) in the Conversion of White-to-brown Adipocytes

(2013) Verónica García-Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamins are rapamycin targets that impact human longevity: a study in centenarians

(2013) G. Lattanzi et al.   JOURNAL OF CELL SCIENCE

Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β

(2012) Cheol-Hee Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution

(2012) Cristina Capanni et al.   CELL CYCLE

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

Dual Specificity Phosphatase 4 Mediates Cardiomyopathy Caused by Lamin A/C (LMNA) Gene Mutation

(2012) Jason C. Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Cold but not sympathomimetics activates human brown adipose tissue in vivo

(2012) A. M. Cypess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy Caused by Lamin A/C Gene Mutation

(2012) J. C. Choi et al.   Science Translational Medicine

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Sp1 Transcription Factor Interaction with Accumulated Prelamin A Impairs Adipose Lineage Differentiation in Human Mesenchymal Stem Cells: Essential Role of Sp1 in the Integrity of Lipid Vesicles

(2012) Garbiñe Ruiz de Eguino et al.   Stem Cells Translational Medicine

LMNA Mutations Induce a Non-Inflammatory Fibrosis and a Brown Fat-Like Dystrophy of Enlarged Cervical Adipose Tissue

(2011) Véronique Béréziat et al.   AMERICAN JOURNAL OF PATHOLOGY

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

(2011) Hong-Min Ni et al.   Autophagy

LMNA-linked lipodystrophies: from altered fat distribution to cellular alterations

(2011) Guillaume Bidault et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Gene expression profiling of subcutaneous adipose tissue in morbid obesity using a focused microarray: Distinct expression of cell-cycle- and differentiation-related genes

(2011) Sara Rodríguez-Acebes et al.   BMC Medical Genomics

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria

(2011) S Dominici et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

(2011) V. Cenni et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Molecular mechanisms of human lipodystrophies: From adipocyte lipid droplet to oxidative stress and lipotoxicity

(2011) Corinne Vigouroux et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Homozygous Mutation of Prelamin-A Preventing Its Farnesylation and Maturation Leads to a Severe Lipodystrophic Phenotype: New Insights into the Pathogenicity of Nonfarnesylated Prelamin-A

(2011) Caroline Le Dour et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Autophagic Degradation of Mitochondria in White Adipose Tissue Differentiation

(2010) Scott J. Goldman et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and adipogenesis: Implications in obesity and type II diabetes

(2010) Scott Goldman et al.   Autophagy

A comprehensive glossary of autophagy-related molecules and processes

(2010) Daniel J. Klionsky et al.   Autophagy

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Brown vs white adipocytes: The PPARγ coregulator story

(2010) Arjen Koppen et al.   FEBS LETTERS

Phosphatidic Acid Is a Leukocyte Chemoattractant That Acts through S6 Kinase Signaling

(2010) Kathleen Frondorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

(2009) Maria Cristina Zingaretti et al.   FASEB JOURNAL

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drugs affecting prelamin A processing: Effects on heterochromatin organization

(2007) Elisabetta Mattioli et al.   EXPERIMENTAL CELL RESEARCH