The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia

Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker

(2015) Kenji Hashimoto   CURRENT PHARMACEUTICAL DESIGN

The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor

(2015) Roger L. Papke et al.   NEUROPHARMACOLOGY

Merging old and new perspectives on nicotinic acetylcholine receptors

(2014) Roger L. Papke   BIOCHEMICAL PHARMACOLOGY

Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication

(2014) William James Deardorff et al.   Expert Review of Neurotherapeutics

Normalizing Effects of EVP-6124, an Alpha-7 Nicotinic Partial Agonist, on Event-Related Potentials and Cognition

(2014) SHELDON H. PRESKORN et al.   Journal of Psychiatric Practice

Human Brain Imaging of α7 nAChR with [18F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy

(2014) Dean F. Wong et al.   MOLECULAR IMAGING AND BIOLOGY

NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats

(2014) Digavalli V. Sivarao et al.   Frontiers in Psychiatry

Impaired GABAergic Inhibition in the Prefrontal Cortex of Early Postnatal Phencyclidine (PCP)-Treated Rats

(2013) C. Kjaerby et al.   CEREBRAL CORTEX

Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats

(2013) Kelli M. Jones et al.   PSYCHOPHARMACOLOGY

Differential expression of parvalbumin in neonatal phencyclidine-treated rats and socially isolated rats

(2012) Sanne S. Kaalund et al.   JOURNAL OF NEUROCHEMISTRY

Quantification of methyllycaconitine, selective α7 nicotinic receptor antagonist, in rodent plasma and brain tissue by liquid chromatography tandem mass spectrometry - application to neuropharmacokinetics of methyllycaconitine in rats

(2011) Ramakrishna Nirogi et al.   BIOMEDICAL CHROMATOGRAPHY

EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

(2011) Jos Prickaerts et al.   NEUROPHARMACOLOGY

Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats

(2011) John P. Redrobe et al.   PSYCHOPHARMACOLOGY

Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models

(2010) Christopher J. O’Donnell et al.   JOURNAL OF MEDICINAL CHEMISTRY

RG3487, a Novel Nicotinic  7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents

(2010) T. L. Wallace et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia

(2010) Akihiro Shiina et al.   Annals of General Psychiatry

TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

(2009) T.A. Hauser et al.   BIOCHEMICAL PHARMACOLOGY

Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors

(2009) Clark A Briggs et al.   BRITISH JOURNAL OF PHARMACOLOGY

α7 and non-α7 nicotinic acetylcholine receptors modulate dopamine releasein vitroandin vivoin the rat prefrontal cortex

(2009) Phil D. Livingstone et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies

(2009) David A. Lewis et al.   JOURNAL OF CLINICAL INVESTIGATION

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Spatial and intracellular relationships between the α7 nicotinic acetylcholine receptor and the vesicular acetylcholine transporter in the prefrontal cortex of rat and mouse

(2009) A.M. Duffy et al.   NEUROSCIENCE

Evaluation of a neurodevelopmental model of schizophrenia—Early postnatal PCP treatment in attentional set-shifting

(2008) Brian Villumsen Broberg et al.   BEHAVIOURAL BRAIN RESEARCH

Functional Expression of Nicotinic Acetylcholine Receptors in Rat Neocortical Layer 5 Pyramidal Cells

(2008) Gerd Zolles et al.   CEREBRAL CORTEX

Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

(2008) Karin R. Tietje et al.   CNS Neuroscience & Therapeutics

α7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice

(2008) John P. Redrobe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

(2008) Dominik Feuerbach et al.   NEUROPHARMACOLOGY

Recent advances in treating cognitive impairment in schizophrenia

(2008) Cherrie Galletly   PSYCHOPHARMACOLOGY

Phencyclidine-Induced Cognitive Deficits in Mice Are Improved by Subsequent Subchronic Administration of the Novel Selective α7 Nicotinic Receptor Agonist SSR180711

(2007) Kenji Hashimoto et al.   BIOLOGICAL PSYCHIATRY