DDX3 Participates in Translational Control of Inflammation Induced by Infections and Injuries

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs

(2018) Ulf-Peter Guenther et al.   NATURE

Role of DDX3 in the pathogenesis of inflammatory bowel disease

(2017) Saritha Tantravedi et al.   Oncotarget

(DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit

(2017) Xin Wang et al.   Oncotarget

The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5

(2017) Abdullah Shah et al.   Stem Cells International

RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3

(2016) Min Xie et al.   CANCER RESEARCH

DDX3 enhances oncogenic KRAS‑induced tumor invasion in colorectal cancer via the β‑catenin/ZEB1 axis

(2016) De‑Wei Wu et al.   Oncotarget

Gnb isoforms control a signaling pathway comprising Rac1, Plc 2, and Plc 3 leading to LFA-1 activation and neutrophil arrest in vivo

(2015) H. Block et al.   BLOOD

CXCL10 induces the recruitment of monocyte-derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis

(2015) D. Petrovic-Djergovic et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

(2015) G. M. Bol et al.   EMBO Molecular Medicine

DDX3 functions in antiviral innate immunity through translational control of PACT

(2015) Ming-Chih Lai et al.   FEBS Journal

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

(2015) Marise R. Heerma van Voss et al.   Oncotarget

The Ded1/DDX3 subfamily of DEAD-box RNA helicases

(2014) Deepak Sharma et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

Large-scale discovery of novel genetic causes of developmental disorders

(2014) T. W. Fitzgerald et al.   NATURE

DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway

(2014) H-H Chen et al.   ONCOGENE

DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication

(2013) Anthony Fullam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

(2013) Priya Luthra et al.   Cell Host & Microbe

Suppression of PACT-Induced Type I Interferon Production by Herpes Simplex Virus 1 Us11 Protein

(2013) C. Kew et al.   JOURNAL OF VIROLOGY

Human DEAD Box Helicase 3 Couples I B Kinase   to Interferon Regulatory Factor 3 Activation

(2013) L. Gu et al.   MOLECULAR AND CELLULAR BIOLOGY

The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA

(2013) Ricardo Soto-Rifo et al.   NUCLEIC ACIDS RESEARCH

Human DDX3 Interacts with the HIV-1 Tat Protein to Facilitate Viral mRNA Translation

(2013) Ming-Chih Lai et al.   PLoS One

Involvement of Stat1 in the Phagocytosis ofM. avium

(2012) Sabrina Dominici et al.   Clinical & Developmental Immunology

DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs

(2012) Ricardo Soto-Rifo et al.   EMBO JOURNAL

Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response

(2011) Jing-Wen Shih et al.   BIOCHEMICAL JOURNAL

The role of DDX3 in regulating Snail

(2011) Mianen Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Characterization of the mononuclear phagocyte system in zebrafish

(2011) V. Wittamer et al.   BLOOD

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The DEAD-Box Protein Ded1 Modulates Translation by the Formation and Resolution of an eIF4F-mRNA Complex

(2011) Angela Hilliker et al.   MOLECULAR CELL

Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish

(2011) Caroline Gray et al.   THROMBOSIS AND HAEMOSTASIS

DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-β-inducing potential

(2010) Hiroyuki Oshiumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DDX3 Regulates Cell Growth through Translational Control of Cyclin E1

(2010) M.-C. Lai et al.   MOLECULAR AND CELLULAR BIOLOGY

Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction

(2010) Hiroyuki Oshiumi et al.   PLoS One

The current understanding of Ded1p/DDX3 homologs from yeast to human

(2010) Woan-Yuh Tarn et al.   RNA Biology

CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue

(2009) Mayoura Keophiphath et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characterization of zebrafish larval inflammatory macrophages

(2009) Jonathan R. Mathias et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

TAK1 activation for cytokine synthesis and proliferation of endometriotic cells

(2009) Fuminori Taniguchi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima

(2008) Young Mi Park et al.   JOURNAL OF CLINICAL INVESTIGATION

The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control

(2008) Ming-Chih Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

(2008) C.-S. Lee et al.   NUCLEIC ACIDS RESEARCH

Oncogenic role of DDX3 in breast cancer biogenesis

(2008) M Botlagunta et al.   ONCOGENE

Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes

(2008) Laura E. Neuder et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

TNF-mediated inflammatory disease

(2007) JR Bradley   JOURNAL OF PATHOLOGY