The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

(2018) Tovah N. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

(2018) David Bauché et al.   IMMUNITY

miR-342-5p Regulates Neural Stem Cell Proliferation and Differentiation Downstream to Notch Signaling in Mice

(2017) Fang Gao et al.   Stem Cell Reports

Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation

(2016) Pawan Kumar et al.   IMMUNITY

RBP-J–Regulated miR-182 Promotes TNF-α–Induced Osteoclastogenesis

(2016) Christine H. Miller et al.   JOURNAL OF IMMUNOLOGY

Citrobacter rodentium mouse model of bacterial infection

(2016) Valerie F Crepin et al.   Nature Protocols

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

(2016) Yingli Shang et al.   Protein & Cell

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

(2016) Julia Foldi et al.   Protein & Cell

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

(2015) Michelle L Robinette et al.   NATURE IMMUNOLOGY

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

(2015) Gregory F Sonnenberg et al.   NATURE MEDICINE

Intestinal macrophages arising from CCR2+ monocytes control pathogen infection by activating innate lymphoid cells

(2015) Sang-Uk Seo et al.   Nature Communications

Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses

(2015) Casandra Panea et al.   Cell Reports

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

CX3CR1+mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

(2014) Randy S. Longman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Citrobacter rodentium: infection, inflammation and the microbiota

(2014) James W. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling

(2014) C. Ishifune et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal macrophages and dendritic cells: what's the difference?

(2014) Vuk Cerovic et al.   TRENDS IN IMMUNOLOGY

Intestinal monocytes and macrophages are required for T cell polarization in response toCitrobacter rodentium

(2013) Heidi A. Schreiber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

(2013) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

Intestinal macrophages: well educated exceptions from the rule

(2013) Ehud Zigmond et al.   TRENDS IN IMMUNOLOGY

microRNA Regulation of Inflammatory Responses

(2012) Ryan M. O'Connell et al.   Annual Review of Immunology

Notch in the Intestine: Regulation of Homeostasis and Pathogenesis

(2012) Taeko K. Noah et al.   Annual Review of Physiology

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

(2012) Samira Tamoutounour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

(2012) Ehud Zigmond et al.   IMMUNITY

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CX3CR1+ macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium

(2012) C Manta et al.   Mucosal Immunology

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Innate IL-17 and IL-22 responses to enteric bacterial pathogens

(2012) Stephen J. Rubino et al.   TRENDS IN IMMUNOLOGY

Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine

(2011) Kanako L. Lewis et al.   IMMUNITY

Both miR-17-5p and miR-20a Alleviate Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating STAT3 Expression

(2011) M. Zhang et al.   JOURNAL OF IMMUNOLOGY

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Interleukin-17 and its expanding biological functions

(2010) Sheng Xu et al.   Cellular & Molecular Immunology

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

(2009) Olga Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways

(2008) Xiaoyu Hu et al.   IMMUNITY

Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes

(2008) Claudia Jakubzick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE