SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

Measurement of trihydroxy-linoleic acids in stratum corneum by tape-stripping: Possible biomarker of barrier function in atopic dermatitis

(2019) Takahito Chiba et al.   PLoS One

Identification of mutations in SDR9C7 in six families with autosomal recessive congenital ichthyosis

(2018) A. Hotz et al.   BRITISH JOURNAL OF DERMATOLOGY

Quantitative image analysis of protein expression and colocalisation in skin sections

(2018) Hanqian Zhang et al.   EXPERIMENTAL DERMATOLOGY

Catalytic activities of mammalian epoxide hydrolases withcisandtransfatty acid epoxides relevant to skin barrier function

(2018) Haruto Yamanashi et al.   JOURNAL OF LIPID RESEARCH

Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11

(2018) Tomoki Maegawa et al.   MAMMALIAN GENOME

Electroporation of mice zygotes with dual guide RNA/Cas9 complexes for simple and efficient cloning-free genome editing

(2018) Marie Teixeira et al.   Scientific Reports

The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function

(2018) Tetsuya Hirabayashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Perspective: Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope

(2018) Debra Crumrine et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function

(2018) Robert W. Davis et al.   TETRAHEDRON LETTERS

PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier

(2017) Mélanie Pichery et al.   HUMAN MOLECULAR GENETICS

Corneocyte lipid envelope (CLE), the key structure for skin barrier function and ichthyosis pathogenesis

(2017) Masashi Akiyama   JOURNAL OF DERMATOLOGICAL SCIENCE

Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease

(2017) Takuya Takeichi et al.   JOURNAL OF DERMATOLOGY

Establishing and Validating an Ichthyosis Severity Index

(2017) Nareh V. Marukian et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides

(2017) Susanne Grond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia

(2017) Takuya Takeichi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation

(2017) Susanne Grond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

(2017) Yusuke Ohno et al.   Nature Communications

PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

(2017) Tetsuya Hirabayashi et al.   Nature Communications

Characterization of TG2 and TG1–TG2 double knock-out mouse epidermis

(2016) Consuelo Pitolli et al.   AMINO ACIDS

The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function

(2016) Takahito Chiba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inherited ichthyosis: Non-syndromic forms

(2016) Takuya Takeichi et al.   JOURNAL OF DERMATOLOGY

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions

(2015) Yukihisa S. Watanabe et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

(2015) Yusuke Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation and functions of the corneocyte lipid envelope (CLE)

(2013) Peter M. Elias et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of lipids in the formation and maintenance of the cutaneous permeability barrier

(2013) Kenneth R. Feingold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier

(2013) Agustí Muñoz-Garcia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of lipoxygenases in epidermis

(2013) Peter Krieg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis

(2013) Christopher P. Thomas et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Current Understanding of Skin Biology Pertinent to Skin Penetration: Skin Biochemistry

(2013) P.W. Wertz   SKIN PHARMACOLOGY AND PHYSIOLOGY

Variations in the ceramide profile in different seasons and regions of the body contribute to stratum corneum functions

(2012) Junko Ishikawa et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Lipoxygenases Mediate the Effect of Essential Fatty Acid in Skin Barrier Formation

(2011) Yuxiang Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models

(2010) Yvonne Kallberg et al.   FEBS Journal

In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O)

(2009) Dorota Kowalik et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY